Display options
Cite
Caballero OL, Shousha S, Zhao Q, et al. Expression of Cancer/Testis genes in ductal carcinoma in situ and benign lesions of the breast. Oncoscience. 2013;1(1):14-20doi: 10.18632/oncoscience.4.
Caballero, O. L., Shousha, S., Zhao, Q., Simpson, A. J. G., Coombes, R. C., & Neville, A. M. (2014). Expression of Cancer/Testis genes in ductal carcinoma in situ and benign lesions of the breast. Oncoscience, 1(1), 14-20. https://doi.org/10.18632/oncoscience.4
Caballero, Otavia L, et al. "Expression of Cancer/Testis genes in ductal carcinoma in situ and benign lesions of the breast." Oncoscience vol. 1,1 (2014): 14-20. doi: https://doi.org/10.18632/oncoscience.4
Caballero OL, Shousha S, Zhao Q, Simpson AJG, Coombes RC, Neville AM. Expression of Cancer/Testis genes in ductal carcinoma in situ and benign lesions of the breast. Oncoscience. 2013 Dec 12;1(1):14-20. doi: 10.18632/oncoscience.4. eCollection 2014. PMID: 25593980; PMCID: PMC4295763.
Copy Download .nbib Format: NLM
Share it on

Oncoscience. 2013 Dec 12;1(1):14-20. doi: 10.18632/oncoscience.4. eCollection 2014.

Expression of Cancer/Testis genes in ductal carcinoma in situ and benign lesions of the breast.

Oncoscience

Otavia L Caballero, Sami Shousha, Qi Zhao, Andrew J G Simpson, R Charles Coombes, A Munro Neville

Affiliations

  1. Ludwig Collaborative Laboratory, Ludwig Institute for Cancer Research, Department of Neurosurgery, The Johns Hopkins University School of Medicine, Baltimore, MD USA.
  2. Imperial College Healthcare NHS Trust & Imperial College, London, Charing Cross Hospital.
  3. Ludwig Institute for Cancer Research, New York, NY., USA.
  4. Current affiliation: Orygen Biotecnologia, São Paulo, Brazil.

PMID: 25593980 PMCID: PMC4295763 DOI: 10.18632/oncoscience.4

Abstract

Cancer/testis (CT) genes represent a unique class of genes, which are expressed by germ cells, normally silenced in somatic cells, but activated in various cancers. CT proteins can elicit spontaneous immune responses in cancer patients and this feature makes them attractive targets for immunotherapy-based approaches. We have previously reported that CTs are relatively commonly expressed in estrogen receptor (ER) negative, high risk carcinomas. In this study, we examined the expression of selected CT genes in ductal carcinoma in situ (DCIS), lobular carcinoma in situ (LCIS) and benign proliferative lesions of the breast. ER negative DCIS were found to be associated with significant CT gene expression together with HER2 positivity and a marked stromal immune response.

Keywords: DCIS; ER negative; cancer/testis genes

References

  1. J Natl Cancer Inst. 2010 May 5;102(9):627-37 - PubMed
  2. PLoS One. 2012;7(6):e38783 - PubMed
  3. Clin Med Oncol. 2008;2:7-18 - PubMed
  4. Clin Lung Cancer. 2009 Sep;10(5):371-4 - PubMed
  5. Cell Cycle. 2013 Jul 1;12 (13):2042-50 - PubMed
  6. J Surg Res. 2011 May 15;167(2):e205-10 - PubMed
  7. BMC Cancer. 2011 Sep 28;11(1):416 - PubMed
  8. Arch Pathol Lab Med. 2013 Apr;137(4):462-6 - PubMed
  9. Proc Natl Acad Sci U S A. 2009 Aug 11;106(32):13493-8 - PubMed
  10. Ann Oncol. 2011 Jan;22(1):98-103 - PubMed
  11. Mol Oncol. 2010 Aug;4(4):357-68 - PubMed
  12. Breast Cancer Res. 2012 Aug 03;14(4):R115 - PubMed
  13. Breast Cancer Res Treat. 2008 Jun;109(3):405-16 - PubMed
  14. Br J Cancer. 2012 Mar 13;106(6):1160-5 - PubMed
  15. Neoplasia. 2004 Jan-Feb;6(1):1-6 - PubMed
  16. Ann Surg Oncol. 2013 Oct;20(10):3233-9 - PubMed
  17. PLoS One. 2011 Mar 18;6(3):e17876 - PubMed
  18. Nat Rev Cancer. 2005 Aug;5(8):615-25 - PubMed
  19. BMC Cancer. 2011 Jan 28;11:42 - PubMed
  20. Int J Cancer. 2001 Jun 15;92(6):856-60 - PubMed
  21. BMC Cancer. 2012 Oct 30;12:500 - PubMed
  22. Cancer Res. 2004 Mar 15;64(6):2199-204 - PubMed
  23. J Pathol. 2011 Jan;223(2):307-17 - PubMed
  24. Clin Cancer Res. 2005 Nov 15;11(22):8055-62 - PubMed
  25. Cancer Epidemiol Biomarkers Prev. 2009 May;18(5):1386-9 - PubMed
  26. Cancer Sci. 2009 Nov;100(11):2014-21 - PubMed
  27. Nucleic Acids Res. 2009 Jan;37(Database issue):D816-9 - PubMed
  28. Oncotarget. 2013 Feb;4(2):231-41 - PubMed

Publication Types