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Sánchez M, Fiz N, Guadilla J, et al. Intraosseous infiltration of platelet-rich plasma for severe knee osteoarthritis. Arthrosc Tech. 2014;3(6):e713-7doi: 10.1016/j.eats.2014.09.006.
Sánchez, M., Fiz, N., Guadilla, J., Padilla, S., Anitua, E., Sánchez, P., & Delgado, D. (2014). Intraosseous infiltration of platelet-rich plasma for severe knee osteoarthritis. Arthroscopy techniques, 3(6), e713-7. https://doi.org/10.1016/j.eats.2014.09.006
Sánchez, Mikel, et al. "Intraosseous infiltration of platelet-rich plasma for severe knee osteoarthritis." Arthroscopy techniques vol. 3,6 (2014): e713-7. doi: https://doi.org/10.1016/j.eats.2014.09.006
Sánchez M, Fiz N, Guadilla J, Padilla S, Anitua E, Sánchez P, Delgado D. Intraosseous infiltration of platelet-rich plasma for severe knee osteoarthritis. Arthrosc Tech. 2014 Dec 15;3(6):e713-7. doi: 10.1016/j.eats.2014.09.006. eCollection 2014 Dec. PMID: 25685680; PMCID: PMC4314556.
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Arthrosc Tech. 2014 Dec 15;3(6):e713-7. doi: 10.1016/j.eats.2014.09.006. eCollection 2014 Dec.

Intraosseous infiltration of platelet-rich plasma for severe knee osteoarthritis.

Arthroscopy techniques

Mikel Sánchez, Nicolás Fiz, Jorge Guadilla, Sabino Padilla, Eduardo Anitua, Pello Sánchez, Diego Delgado

Affiliations

  1. Arthroscopic Surgery Unit, Hospital Vithas San Jose, Vitoria-Gasteiz, Spain.
  2. Arthroscopic Surgery Unit, Hospital Vithas San Jose, Vitoria-Gasteiz, Spain ; Biotechnology Institute, Vitoria-Gasteiz, Spain.
  3. Biotechnology Institute, Vitoria-Gasteiz, Spain ; Foundation Eduardo Anitua, Vitoria-Gasteiz, Spain.
  4. Arthroscopic Surgery Unit Research, Hospital Vithas San Jose, Vitoria-Gasteiz, Spain.

PMID: 25685680 PMCID: PMC4314556 DOI: 10.1016/j.eats.2014.09.006

Abstract

We describe a new technique of platelet-rich plasma (PRP) infiltration for the treatment of severe knee osteoarthritis. PRP intra-articular infiltration is a promising treatment for knee osteoarthritis, but it still has some limitations in high-degree osteoarthritis. Diagnosis of osteoarthritis is based on clinical and radiographic findings, and patients with grade III or IV knee tibiofemoral osteoarthritis based on the Ahlbäck scale are considered candidates for this technique. The technique consists of performing intraosseous infiltration of PRP into the subchondral bone, which acts on this tissue and consequently on cartilage-bone communication. Although the intraosseous injection hinders the conventional knee intra-articular infiltration, it allows an extension of the range of action of the PRP, which acts directly on the subchondral bone, which is involved in the progression of osteoarthritis. Thus this technique involves a new administration of PRP that can delay knee arthroplasty; moreover, it can be applied for not only severe osteoarthritis but also other pathologies in which the subchondral bone is critical in the etiology, such as necrosis and osteochondral lesions.

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