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Cao L, Bie X, Huo S, et al. Effects of diazepam on glutamatergic synaptic transmission in the hippocampal CA1 area of rats with traumatic brain injury. Neural Regen Res. 2014;9(21):1897-901doi: 10.4103/1673-5374.145357.
Cao, L., Bie, X., Huo, S., Du, J., Liu, L., & Song, W. (2014). Effects of diazepam on glutamatergic synaptic transmission in the hippocampal CA1 area of rats with traumatic brain injury. Neural regeneration research, 9(21), 1897-901. https://doi.org/10.4103/1673-5374.145357
Cao, Lei, et al. "Effects of diazepam on glutamatergic synaptic transmission in the hippocampal CA1 area of rats with traumatic brain injury." Neural regeneration research vol. 9,21 (2014): 1897-901. doi: https://doi.org/10.4103/1673-5374.145357
Cao L, Bie X, Huo S, Du J, Liu L, Song W. Effects of diazepam on glutamatergic synaptic transmission in the hippocampal CA1 area of rats with traumatic brain injury. Neural Regen Res. 2014 Nov 01;9(21):1897-901. doi: 10.4103/1673-5374.145357. PMID: 25558239; PMCID: PMC4281428.
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Neural Regen Res. 2014 Nov 01;9(21):1897-901. doi: 10.4103/1673-5374.145357.

Effects of diazepam on glutamatergic synaptic transmission in the hippocampal CA1 area of rats with traumatic brain injury.

Neural regeneration research

Lei Cao, Xiaohua Bie, Su Huo, Jubao Du, Lin Liu, Weiqun Song

Affiliations

  1. Department of Functional Neurosurgery, Xi'an Red Cross Hospital, Xi'an, Shaanxi Province, China ; Department of Rehabilitation Medicine, Xuanwu Hospital, Capital Medical University, Beijing, China.
  2. Department of Functional Neurosurgery, Xi'an Red Cross Hospital, Xi'an, Shaanxi Province, China.
  3. Department of Rehabilitation Medicine, Xuanwu Hospital, Capital Medical University, Beijing, China.

PMID: 25558239 PMCID: PMC4281428 DOI: 10.4103/1673-5374.145357

Abstract

The activity of the Schaffer collaterals of hippocampal CA3 neurons and hippocampal CA1 neurons has been shown to increase after fluid percussion injury. Diazepam can inhibit the hyperexcitability of rat hippocampal neurons after injury, but the mechanism by which it affects excitatory synaptic transmission remains poorly understood. Our results showed that diazepam treatment significantly increased the slope of input-output curves in rat neurons after fluid percussion injury. Diazepam significantly decreased the numbers of spikes evoked by super stimuli in the presence of 15 μmol/L bicuculline, indicating the existence of inhibitory pathways in the injured rat hippocampus. Diazepam effectively increased the paired-pulse facilitation ratio in the hippocampal CA1 region following fluid percussion injury, reduced miniature excitatory postsynaptic potentials, decreased action-potential-dependent glutamine release, and reversed spontaneous glutamine release. These data suggest that diazepam could decrease the fluid percussion injury-induced enhancement of excitatory synaptic transmission in the rat hippocampal CA1 area.

Keywords: NSFC grant; excitatory synaptic transmission; fluid percussion injury; gamma-aminobutyric acid; hippocampal CA1 pyramidal neurons; intracellular recording; miniature excitatory postsynaptic potential; nerve regeneration; neural regeneration; paired-pulse facilitation; post-traumatic hyperactivity; traumatic brain injury

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