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Strupp M, Feil K, Bardins S, et al. 4-aminopyridine improves lower urinary tract symptoms in a patient with benign prostatic hyperplasia and downbeat nystagmus syndrome. Int Neurourol J. 2014;18(4):221-5doi: 10.5213/inj.2014.18.4.221.
Strupp, M., Feil, K., Bardins, S., & Waidelich, R. (2014). 4-aminopyridine improves lower urinary tract symptoms in a patient with benign prostatic hyperplasia and downbeat nystagmus syndrome. International neurourology journal, 18(4), 221-5. https://doi.org/10.5213/inj.2014.18.4.221
Strupp, Michael, et al. "4-aminopyridine improves lower urinary tract symptoms in a patient with benign prostatic hyperplasia and downbeat nystagmus syndrome." International neurourology journal vol. 18,4 (2014): 221-5. doi: https://doi.org/10.5213/inj.2014.18.4.221
Strupp M, Feil K, Bardins S, Waidelich R. 4-aminopyridine improves lower urinary tract symptoms in a patient with benign prostatic hyperplasia and downbeat nystagmus syndrome. Int Neurourol J. 2014 Dec;18(4):221-5. doi: 10.5213/inj.2014.18.4.221. Epub 2014 Dec 29. PMID: 25558420; PMCID: PMC4280442.
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Int Neurourol J. 2014 Dec;18(4):221-5. doi: 10.5213/inj.2014.18.4.221. Epub 2014 Dec 29.

4-aminopyridine improves lower urinary tract symptoms in a patient with benign prostatic hyperplasia and downbeat nystagmus syndrome.

International neurourology journal

Michael Strupp, Katharina Feil, Stanislavs Bardins, Raphaela Waidelich

Affiliations

  1. Department of Neurology, University Hospital Munich, Campus Grosshadern, Munich, Germany. ; German Center for Vertigo and Balance Disorders, University Hospital Munich, Campus Grosshadern, Munich, Germany.
  2. German Center for Vertigo and Balance Disorders, University Hospital Munich, Campus Grosshadern, Munich, Germany.
  3. Department of Urology, University Hospital Munich, Campus Grosshadern, Munich, Germany.

PMID: 25558420 PMCID: PMC4280442 DOI: 10.5213/inj.2014.18.4.221

Abstract

Aminopyridines are potassium channel blockers that increase the excitability of nerve cells and axons; therefore, they are widely used to treat different neurological disorders. Here we present a patient with idiopathic downbeat nystagmus and lower urinary tract symptoms (LUTS) due to benign prostatic hyperplasia who was treated with the sustained-release form of 4-aminopyridine (4-AP). During treatment with 4-AP, the LUTS improved. This improvement was monitored by using uroflowmetry and the International Prostate Symptom Score. A significant improvement of symptoms was observed in relation to the voided volume. This included an improved emptying of the bladder without an increase in residual urine. In animal studies, both nonselective K(+) channel blockade and selective voltage-sensitive potassium blockade by 4-AP resulted in increased contraction on rat detrusor strips. To our knowledge, this is the first clinical observation of the mode of action of 4-AP in urological symptoms in humans.

Keywords: 4-Aminopyridine; Drug Therapy; Lower Urinary Tract Symptoms; Neurogenic Urinary Bladder; Prostatic Hyperplasia

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