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Hibi T, Shinoda M, Itano O, et al. Steroid minimization immunosuppression protocol using basiliximab in adult living donor liver transplantation for hepatitis C virus-related cirrhosis. Hepatol Res. 2015;45(12):1178-84doi: 10.1111/hepr.12486.
Hibi, T., Shinoda, M., Itano, O., Obara, H., Kitago, M., Abe, Y., Yagi, H., Tanaka, M., Hoshino, K., Fujino, A., Kuroda, T., Kawachi, S., Tanabe, M., Shimazu, M., & Kitagawa, Y. (2015). Steroid minimization immunosuppression protocol using basiliximab in adult living donor liver transplantation for hepatitis C virus-related cirrhosis. Hepatology research : the official journal of the Japan Society of Hepatology, 45(12), 1178-84. https://doi.org/10.1111/hepr.12486
Hibi, Taizo, et al. "Steroid minimization immunosuppression protocol using basiliximab in adult living donor liver transplantation for hepatitis C virus-related cirrhosis." Hepatology research : the official journal of the Japan Society of Hepatology vol. 45,12 (2015): 1178-84. doi: https://doi.org/10.1111/hepr.12486
Hibi T, Shinoda M, Itano O, Obara H, Kitago M, Abe Y, Yagi H, Tanaka M, Hoshino K, Fujino A, Kuroda T, Kawachi S, Tanabe M, Shimazu M, Kitagawa Y. Steroid minimization immunosuppression protocol using basiliximab in adult living donor liver transplantation for hepatitis C virus-related cirrhosis. Hepatol Res. 2015 Dec;45(12):1178-84. doi: 10.1111/hepr.12486. Epub 2015 Feb 26. PMID: 25594837.
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Hepatol Res. 2015 Dec;45(12):1178-84. doi: 10.1111/hepr.12486. Epub 2015 Feb 26.

Steroid minimization immunosuppression protocol using basiliximab in adult living donor liver transplantation for hepatitis C virus-related cirrhosis.

Hepatology research : the official journal of the Japan Society of Hepatology

Taizo Hibi, Masahiro Shinoda, Osamu Itano, Hideaki Obara, Minoru Kitago, Yuta Abe, Hiroshi Yagi, Masayuki Tanaka, Ken Hoshino, Akihiro Fujino, Tatsuo Kuroda, Shigeyuki Kawachi, Minoru Tanabe, Motohide Shimazu, Yuko Kitagawa

Affiliations

  1. Department of Surgery, Keio University School of Medicine.
  2. Division of Digestive Surgery and Transplantation Surgery, Tokyo Medical University Hachioji Medical Center.
  3. Department of Hepatobiliary and Pancreatic Surgery, Tokyo Medical and Dental University, Tokyo, Japan.

PMID: 25594837 DOI: 10.1111/hepr.12486

Abstract

AIM: Recent randomized trials have failed to prove the benefit of steroid-free immunosuppression in liver transplantation for hepatitis C virus (HCV)-related cirrhosis. Furthermore, there is a lack of data on the use of basiliximab in living donor liver transplantation (LDLT). This pilot study evaluated the safety and efficacy of a steroid minimization protocol using basiliximab compared with standard immunosuppression.

METHODS: A single center, prospective cohort analysis was conducted to compare two immunosuppression regimens in adult recipients who underwent LDLT for HCV since 2004: calcineurin inhibitor/mizoribine/basiliximab (the St- group) and calcineurin inhibitor/mizoribine/steroid (the St+ group). Study end-points were rejection rates, recurrent HCV, patient survival and other adverse events up to 2 years after transplantation.

RESULTS: A total of 27 consecutive patients were enrolled. Transplantation characteristics were similar between the two groups (14 St- and 13 St+) except ABO incompatible cases being more common in the St+ group. Rejection rates, recurrent HCV, patient survival, fibrosis stage and new-onset diabetes mellitus at 2 years were comparable between the two groups. ABO incompatibility did not affect short- and long-term outcomes. Nine St- and seven St+ recipients underwent interferon and ribavirin therapy for recurrent HCV, with a sustained virological response rate of 33% and 29%, respectively.

CONCLUSION: A steroid minimization protocol with basiliximab in adult LDLT for HCV is safe and affords equivalent rejection rates compared with standard immunosuppression. However, no significant differences are observed with respect to recurrent HCV, patient survival and metabolic complications.

© 2015 The Japan Society of Hepatology.

Keywords: basiliximab; hepatitis C virus; immunosuppression; liver transplantation; living donors; steroids

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