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Clin Med Insights Cardiol. 2015 Jan 26;8:53-65. doi: 10.4137/CMC.S15717. eCollection 2014.

Hypertrophic cardiomyopathy: a review.

Clinical Medicine Insights. Cardiology

Brian A Houston, Gerin R Stevens

Affiliations

  1. Division of Cardiology, Department of Medicine, Johns Hopkins Hospital, Baltimore, MD, USA.

PMID: 25657602 PMCID: PMC4309724 DOI: 10.4137/CMC.S15717

Abstract

Hypertrophic cardiomyopathy (HCM) is a global disease with cases reported in all continents, affecting people of both genders and of various racial and ethnic origins. Widely accepted as a monogenic disease caused by a mutation in 1 of 13 or more sarcomeric genes, HCM can present catastrophically with sudden cardiac death (SCD) or ventricular arrhythmias or insidiously with symptoms of heart failure. Given the velocity of progress in both the fields of heart failure and HCM, we present a review of the approach to patients with HCM, with particular attention to those with HCM and the clinical syndrome of heart failure.

Keywords: LV hypertrophy; heart failure; hypertrophic cardiomyopathy

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