Display options
Cite
Sreevalsan S, Safe S. REACTIVE OXYGEN SPECIES AND COLORECTAL CANCER. Curr Colorectal Cancer Rep. 2013;9(4):350-357doi: 10.1007/s11888-013-0190-5.
Sreevalsan, S., & Safe, S. (2013). REACTIVE OXYGEN SPECIES AND COLORECTAL CANCER. Current colorectal cancer reports, 9(4), 350-357. https://doi.org/10.1007/s11888-013-0190-5
Sreevalsan, Sandeep, and Safe, Stephen. "REACTIVE OXYGEN SPECIES AND COLORECTAL CANCER." Current colorectal cancer reports vol. 9,4 (2013): 350-357. doi: https://doi.org/10.1007/s11888-013-0190-5
Sreevalsan S, Safe S. REACTIVE OXYGEN SPECIES AND COLORECTAL CANCER. Curr Colorectal Cancer Rep. 2013 Dec;9(4):350-357. doi: 10.1007/s11888-013-0190-5. PMID: 25584043; PMCID: PMC4288935.
Copy Download .nbib Format: NLM
Share it on

Curr Colorectal Cancer Rep. 2013 Dec;9(4):350-357. doi: 10.1007/s11888-013-0190-5.

REACTIVE OXYGEN SPECIES AND COLORECTAL CANCER.

Current colorectal cancer reports

Sandeep Sreevalsan, Stephen Safe

Affiliations

  1. VMR 1197, Room 413, Texas A&M University, College Station, TX, 77843 979-845-9182 [email protected].
  2. VMR 1197, Room 410, Texas A&M University, College Station, TX, 77843 979-845-5988.

PMID: 25584043 PMCID: PMC4288935 DOI: 10.1007/s11888-013-0190-5

Abstract

Several agents used for treatment of colon and other cancers induce reactive oxygen species (ROS) and this plays an important role in their anticancer activities. In addition to the well-known proapoptotic effects of ROS inducers, these compounds also decrease expression of specificity protein (Sp) transcription factors Sp1, Sp3 and Sp4 and several pro-oncogenic Spregulated genes important for cancer cell proliferation, survival and metastasis. The mechanism of these responses involve ROS-dependent downregulation of microRNA-27a (miR-27a) or miR-20a (and paralogs) and induction of two Sp-repressors, ZBTB10 and ZBTB4 respectively. This pathway significantly contributes to the anticancer activity of ROS inducers and should be considered in development of drug combinations for cancer chemotherapy.

Keywords: Colon cancer; antioxidants; mechanism based drugs; microRNA; reactive oxygen Species; specificity transcription factors; targeted therapy; zinc finger DNA binding proteins

References

  1. Biochem Biophys Res Commun. 1989 Oct 16;164(1):149-55 - PubMed
  2. Nutr Cancer. 2011;63(7):1133-42 - PubMed
  3. Science. 1985 Nov 1;230(4725):511-7 - PubMed
  4. J Gerontol A Biol Sci Med Sci. 1996 Jan;51(1):B66-75 - PubMed
  5. J Inorg Biochem. 2013 Jul;124:78-87 - PubMed
  6. Nat Chem Biol. 2011 Jul 18;7(8):504-11 - PubMed
  7. J Environ Pathol Toxicol Oncol. 2012;31(2):95-107 - PubMed
  8. Cancer Res. 2004 Sep 15;64(18):6740-9 - PubMed
  9. Cell Death Dis. 2011 Aug 11;2:e191 - PubMed
  10. Prostaglandins Leukot Essent Fatty Acids. 2013 Apr;88(4):273-80 - PubMed
  11. Am J Epidemiol. 1996 Jul 1;144(1):34-41 - PubMed
  12. J Carcinog. 2006 May 11;5:14 - PubMed
  13. Mol Pharmacol. 2005 Aug;68(2):317-29 - PubMed
  14. Food Chem. 2013 Jun 1;138(2-3):1521-30 - PubMed
  15. Int J Cancer. 2013 Sep 15;133(6):1447-51 - PubMed
  16. J Cell Physiol. 2002 Jul;192(1):1-15 - PubMed
  17. CA Cancer J Clin. 2005 Mar-Apr;55(2):74-108 - PubMed
  18. Biochim Biophys Acta. 2013 Apr;1831(4):759-68 - PubMed
  19. Mol Nutr Food Res. 2013 Sep;57(9):1638-48 - PubMed
  20. Biochem Soc Trans. 2001 May;29(Pt 2):345-50 - PubMed
  21. EMBO J. 2008 Jun 4;27(11):1563-74 - PubMed
  22. J Cell Physiol. 2001 Aug;188(2):143-60 - PubMed
  23. J Cell Physiol. 2005 Apr;203(1):78-84 - PubMed
  24. Chem Biol Interact. 2007 Sep 20;169(3):198-206 - PubMed
  25. Cancer Cell. 2011 Nov 15;20(5):606-19 - PubMed
  26. Biochem Biophys Res Commun. 2006 Jun 23;345(1):292-301 - PubMed
  27. Cancer Res. 2007 Apr 1;67(7):3286-94 - PubMed
  28. J Bioenerg Biomembr. 2008 Dec;40(6):607-18 - PubMed
  29. Exp Cell Res. 2010 Aug 1;316(13):2174-88 - PubMed
  30. N Engl J Med. 1988 Oct 20;319(16):1047-52 - PubMed
  31. Mol Cancer Ther. 2011 Jul;10(7):1161-72 - PubMed
  32. Biochem Biophys Res Commun. 2007 Feb 2;353(1):86-91 - PubMed
  33. Cancer Epidemiol Biomarkers Prev. 2009 Jun;18(6):1688-94 - PubMed
  34. Cancer Res. 2008 Mar 15;68(6):1777-85 - PubMed
  35. J Nat Prod. 2012 Dec 28;75(12):2088-93 - PubMed
  36. Gastroenterology. 2010 Jun;138(6):2029-2043.e10 - PubMed
  37. Cancer Res. 2008 Jul 1;68(13):5345-54 - PubMed
  38. Eur J Cancer. 2005 Nov;41(16):2438-48 - PubMed
  39. Gene. 1999 Oct 1;238(2):291-300 - PubMed
  40. Mol Cells. 2013 Jun;35(6):526-32 - PubMed
  41. Oncogene. 2012 Feb 23;31(8):1034-44 - PubMed
  42. BMC Cancer. 2012 Nov 30;12:564 - PubMed
  43. Cell Death Differ. 2008 Jan;15(1):171-82 - PubMed
  44. Cancer Sci. 2004 Apr;95(4):361-6 - PubMed
  45. Cancer Res. 2007 Nov 15;67(22):11001-11 - PubMed
  46. Cancer Res. 2006 Feb 1;66(3):1277-81 - PubMed
  47. J Natl Cancer Inst. 2006 Jun 21;98(12):855-68 - PubMed
  48. J Biol Chem. 2004 Aug 13;279(33):34643-54 - PubMed
  49. J Asian Nat Prod Res. 2010 Nov;12(11):992-1000 - PubMed
  50. J Biol Chem. 1992 Sep 5;267(25):17944-8 - PubMed
  51. J Biol Chem. 1999 Mar 19;274(12):8123-8 - PubMed
  52. Mol Cancer Res. 2011 Feb;9(2):195-202 - PubMed
  53. Cancer Res. 2007 Mar 15;67(6):2816-23 - PubMed
  54. CA Cancer J Clin. 2011 Mar-Apr;61(2):69-90 - PubMed
  55. Cell Death Dis. 2011 Apr 28;2:e152 - PubMed
  56. Mol Cell Endocrinol. 2002 Sep 30;195(1-2):27-38 - PubMed
  57. Mol Cancer Ther. 2009 Aug;8(8):2441-51 - PubMed
  58. J Transl Med. 2013 Feb 08;11:32 - PubMed
  59. Br J Nutr. 2013 Sep 14;110(5):797-809 - PubMed
  60. Cell Death Dis. 2013 Jun 06;4:e653 - PubMed
  61. Antioxid Redox Signal. 2012 Jun 1;16(11):1295-322 - PubMed
  62. Aging Dis. 2011 Jun;2(3):219-30 - PubMed
  63. EMBO J. 1992 Oct;11(10):3663-71 - PubMed
  64. BMC Cancer. 2011 Aug 24;11:371 - PubMed

Publication Types

Grant support