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Niu S, Kou S, Zhou X, et al. Heshouwu decoction, a Chinese herb for tonifying kidney, ameliorates hypothalamic-pituitary- testicular axis secretion in aging rats. Neural Regen Res. 2012;7(21):1611-7doi: 10.3969/j.issn.1673-5374.2012.21.002.
Niu, S., Kou, S., Zhou, X., & Ding, L. (2012). Heshouwu decoction, a Chinese herb for tonifying kidney, ameliorates hypothalamic-pituitary- testicular axis secretion in aging rats. Neural regeneration research, 7(21), 1611-7. https://doi.org/10.3969/j.issn.1673-5374.2012.21.002
Niu, Siyun, et al. "Heshouwu decoction, a Chinese herb for tonifying kidney, ameliorates hypothalamic-pituitary- testicular axis secretion in aging rats." Neural regeneration research vol. 7,21 (2012): 1611-7. doi: https://doi.org/10.3969/j.issn.1673-5374.2012.21.002
Niu S, Kou S, Zhou X, Ding L. Heshouwu decoction, a Chinese herb for tonifying kidney, ameliorates hypothalamic-pituitary- testicular axis secretion in aging rats. Neural Regen Res. 2012 Jul 25;7(21):1611-7. doi: 10.3969/j.issn.1673-5374.2012.21.002. PMID: 25657700; PMCID: PMC4308762.
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Neural Regen Res. 2012 Jul 25;7(21):1611-7. doi: 10.3969/j.issn.1673-5374.2012.21.002.

Heshouwu decoction, a Chinese herb for tonifying kidney, ameliorates hypothalamic-pituitary- testicular axis secretion in aging rats.

Neural regeneration research

Siyun Niu, Suru Kou, Xiaochun Zhou, Liang Ding

Affiliations

  1. School of Basic Medical Science, Hebei University, Baoding 071000, Hebei Province, China.
  2. Institute of Basic Medical Sciences, Chengde Medical College, Chengde 067000, Hebei Province, China.

PMID: 25657700 PMCID: PMC4308762 DOI: 10.3969/j.issn.1673-5374.2012.21.002

Abstract

An increasing amount of evidence demonstrates the anti-aging effect of Heshouwu in pill form. In this study, a subacute aging rat model was established by continuous intraperitoneal injection of D-galactose and treated with Heshouwu decoction (a Chinese herb for tonifying the kidney, comprising Heshouwu pill, Herba Epimedii, Radix Salviae Miltiorrhiae, and Poria). Heshouwu pill treated rats were the positive control group. Radioimmunoassay, immunohistochemical staining, and western blot assay showed hypothalamic gonadotropin-releasing hormone, hypothalamic substance P, and serum gonadotropin levels to be significantly increased in the model rats; the concentrations of hypothalamic β-endorphin, and serum levels of insulin-like growth factor 1 and testosterone were significantly decreased. 17β- and 3β-hydroxysteroid dehydrogenase expression in testicular tissue was also decreased. Intragastric administration of Heshouwu decoction at high (9.6 g/mL/100 g), medium (4.8 g/mL/100 g), and low (2.4 g/mL/100 g) doses, Heshouwu decoction pretreatment at a medium dose (4.8 g/mL/100 g), and Heshouwu pill (2.06 g/mL/100 g) significantly reversed these changes. Heshouwu decoction pretreatment and high-dose Heshouwu decoction had the greatest anti-aging effects. These experimental findings indicate that Heshouwu decoction can improve hypothalamic-pituitary-testicular axis secretion in a subacute aging rat model, and prevent and delay gonadal axis aging, with an effect superior to that of Heshouwu pill.

Keywords: Heshouwu decoction; aging; gonadotropin; gonadotropin-releasing hormone; hydroxysteroid dehydrogenase; hypothalamic-pituitary-testicular axis; neural regeneration; pituitary gonadal axis

References

  1. Trends Endocrinol Metab. 2011 Nov;22(11):437-42 - PubMed
  2. Am J Physiol. 1997 Oct;273(4 Pt 2):R1407-13 - PubMed
  3. Mech Ageing Dev. 1999 May 17;108(3):239-51 - PubMed
  4. Mol Cell Endocrinol. 2007 Feb;265-266:131-7 - PubMed
  5. J Biol Chem. 2006 Nov 17;281(46):35048-56 - PubMed
  6. FEBS Lett. 2007 Aug 21;581(21):4023-8 - PubMed
  7. Clin Exp Pharmacol Physiol. 2001 Apr;28(4):285-9 - PubMed
  8. Exp Gerontol. 1998 Nov-Dec;33(7-8):729-57 - PubMed
  9. J Clin Endocrinol Metab. 1992 Sep;75(3):707-13 - PubMed
  10. Bioorg Med Chem. 2010 Feb;18(3):999-1002 - PubMed

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