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Kowalski ML, Makowska JS. Seven steps to the diagnosis of NSAIDs hypersensitivity: how to apply a new classification in real practice?. Allergy Asthma Immunol Res. 2015;7(4):312-20doi: 10.4168/aair.2015.7.4.312.
Kowalski, M. L., & Makowska, J. S. (2015). Seven steps to the diagnosis of NSAIDs hypersensitivity: how to apply a new classification in real practice?. Allergy, asthma & immunology research, 7(4), 312-20. https://doi.org/10.4168/aair.2015.7.4.312
Kowalski, Marek L, and Makowska, Joanna S. "Seven steps to the diagnosis of NSAIDs hypersensitivity: how to apply a new classification in real practice?." Allergy, asthma & immunology research vol. 7,4 (2015): 312-20. doi: https://doi.org/10.4168/aair.2015.7.4.312
Kowalski ML, Makowska JS. Seven steps to the diagnosis of NSAIDs hypersensitivity: how to apply a new classification in real practice?. Allergy Asthma Immunol Res. 2015 Jul;7(4):312-20. doi: 10.4168/aair.2015.7.4.312. Epub 2015 Mar 05. PMID: 25749768; PMCID: PMC4446629.
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Allergy Asthma Immunol Res. 2015 Jul;7(4):312-20. doi: 10.4168/aair.2015.7.4.312. Epub 2015 Mar 05.

Seven steps to the diagnosis of NSAIDs hypersensitivity: how to apply a new classification in real practice?.

Allergy, asthma & immunology research

Marek L Kowalski, Joanna S Makowska

Affiliations

  1. Department of Immunology, Rheumatology and Allergy, Medical University of Lodz, Lodz, Poland. [email protected].
  2. Department of Immunology, Rheumatology and Allergy, Medical University of Lodz, Lodz, Poland.

PMID: 25749768 PMCID: PMC4446629 DOI: 10.4168/aair.2015.7.4.312

Abstract

Frequent use of non-steroidal anti-inflammatory drugs (NSAIDs) has been paralleled by increasing occurrence of adverse reactions, which vary from mild local skin rashes or gastric irritation to severe, generalized symptoms and even life-threatening anaphylaxis. NSAID-induced hypersensitivity reactions may involve both immunological and non-immunological mechanisms and should be differentiated from type A adverse reactions. Clinical diagnosis and effective management of a hypersensitive patient cannot be achieved without identifying the underlying mechanism. In this review, we discuss the current classification of NSAID-induced adverse reactions and propose a practical diagnostic algorithm that involves 7 steps leading to the determination of the type of NSAID-induced hypersensitivity and allows for proper patient management.

Keywords: NSAID-induced hypersensitivity; Nonsteroidal anti-inflammatory drugs; aspirin; aspirin hypersensitivity; drug allergy

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