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Caizzone A, Saladino E, Fleres F, et al. Giant retroperitoneal liposarcoma: Case report and review of the literature. Int J Surg Case Rep. 2015;9:23-6doi: 10.1016/j.ijscr.2015.02.019.
Caizzone, A., Saladino, E., Fleres, F., Paviglianiti, C., Iaropoli, F., Mazzeo, C., Cucinotta, E., & Macrì, A. (2015). Giant retroperitoneal liposarcoma: Case report and review of the literature. International journal of surgery case reports, 923-6. https://doi.org/10.1016/j.ijscr.2015.02.019
Caizzone, Antonio, et al. "Giant retroperitoneal liposarcoma: Case report and review of the literature." International journal of surgery case reports vol. 9 (2015): 23-6. doi: https://doi.org/10.1016/j.ijscr.2015.02.019
Caizzone A, Saladino E, Fleres F, Paviglianiti C, Iaropoli F, Mazzeo C, Cucinotta E, Macrì A. Giant retroperitoneal liposarcoma: Case report and review of the literature. Int J Surg Case Rep. 2015;9:23-6. doi: 10.1016/j.ijscr.2015.02.019. Epub 2015 Feb 17. PMID: 25722109; PMCID: PMC4392328.
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Int J Surg Case Rep. 2015;9:23-6. doi: 10.1016/j.ijscr.2015.02.019. Epub 2015 Feb 17.

Giant retroperitoneal liposarcoma: Case report and review of the literature.

International journal of surgery case reports

Antonio Caizzone, Edoardo Saladino, Francesco Fleres, Cosimo Paviglianiti, Francesco Iaropoli, Carmelo Mazzeo, Eugenio Cucinotta, Antonio Macrì

Affiliations

  1. Institution and Department of Human Pathology, University of Messina, Via Consolare Valeria, 98125 Messina, Italy.
  2. Institution and Department of Human Pathology, University of Messina, Via Consolare Valeria, 98125 Messina, Italy. Electronic address: [email protected].

PMID: 25722109 PMCID: PMC4392328 DOI: 10.1016/j.ijscr.2015.02.019

Abstract

AIM: Retroperitoneal soft-tissue sarcomas are relatively uncommon diseases, the most frequent histotype, ranging from 20% to 45% of all cases, is represented by liposarcoma, which is a hard-to treat condition for its local aggressiveness and clinical aspecificity.

PRESENTATION OF CASE: We report a case of a 64-years-old woman who underwent surgical resection for a giant pleomorphic retroperitoneal liposarcoma.

DISCUSSION: Currently chemotherapy for retroperitoneal soft-tissue sarcomas is no effective, and radiotherapy has limited efficacy due to the toxicity affecting adjacent intra-abdominal structures, showed validity only in case of high-grade malignancy by reducing local recurrence, but with no advantage in overall survival. Nowadays only, the complete surgical resection remains the most important predictor of local recurrence and overall survival.

CONCLUSION: The removal of a retroperitoneal sarcoma of remarkable size is a challenge for the surgeon owing to the anatomical site, to the absence of an anatomically evident vascular-lymphatic peduncle and to the adhesions contracted with the contiguous organs and with the great vessels. Therefore, we believe that, particularly for large-size diseases associated to high-grade malignancy, a complete surgical resection with removal of the contiguous intra and retroperitoneal organs when infiltrated represents the only therapeutic option to obtain a negative margin and therefore an oncological radicality.

Copyright © 2015 The Authors. Published by Elsevier Ltd.. All rights reserved.

Keywords: Myxoid areas; Radical treatment; Retroperitoneal liposarcoma; Soft tissue sarcomas

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