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Douraghy A, Rannou FR, Silverman RW, et al. FPGA Electronics for OPET: A Dual-Modality Optical and Positron Emission Tomograph. IEEE Trans Nucl Sci. 2008;55(5):2541-2545doi: 10.1109/TNS.2008.2002257.
Douraghy, A., Rannou, F. R., Silverman, R. W., & Chatziioannou, A. F. (2008). FPGA Electronics for OPET: A Dual-Modality Optical and Positron Emission Tomograph. IEEE transactions on nuclear science, 55(5), 2541-2545. https://doi.org/10.1109/TNS.2008.2002257
Douraghy, Ali, et al. "FPGA Electronics for OPET: A Dual-Modality Optical and Positron Emission Tomograph." IEEE transactions on nuclear science vol. 55,5 (2008): 2541-2545. doi: https://doi.org/10.1109/TNS.2008.2002257
Douraghy A, Rannou FR, Silverman RW, Chatziioannou AF. FPGA Electronics for OPET: A Dual-Modality Optical and Positron Emission Tomograph. IEEE Trans Nucl Sci. 2008 Oct 01;55(5):2541-2545. doi: 10.1109/TNS.2008.2002257. PMID: 25722497; PMCID: PMC4338985.
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IEEE Trans Nucl Sci. 2008 Oct 01;55(5):2541-2545. doi: 10.1109/TNS.2008.2002257.

FPGA Electronics for OPET: A Dual-Modality Optical and Positron Emission Tomograph.

IEEE transactions on nuclear science

Ali Douraghy, Fernando R Rannou, Robert W Silverman, Arion F Chatziioannou

Affiliations

  1. UCLA David Geffen School of Medicine, Crump Institute for Molecular Imaging, Los Angeles, CA 90095 USA ( [email protected] ).
  2. Department de Ingenieria Informatica, Universidad de Santiago de Chile, 7251657 Santiago, Chile ( [email protected] ).
  3. UCLA David Geffen School of Medicine, Crump Institute for Molecular Imaging, Los Angeles, CA 90095 USA ( [email protected] ).
  4. UCLA David Geffen School of Medicine, Crump Institute for Molecular Imaging, Los Angeles, CA 90095 USA ( [email protected] ).

PMID: 25722497 PMCID: PMC4338985 DOI: 10.1109/TNS.2008.2002257

Abstract

The development of a prototype dual-modality optical and PET (OPET) small animal imaging tomograph is underway in the Crump Institute for Molecular Imaging at the University of California Los Angeles. OPET consists of a single ring of six detector modules with a diameter of 3.5 cm. Each detector has an 8 × 8 array of optically isolated BGO scintillators which are coupled to multichannel photomultiplier tubes and open on the front end. The system operates in either PET or optical mode and reconstructs the data sets as 3D tomograms. The detectors are capable of detecting both annihilation events (511 keV) from PET tracers as well as Single Photon Events (SPEs) (2-3 eV) from bioluminescence. Detector channels are readout using a custom multiplex readout scheme and then filtered in analog circuitry using either a γ-ray or SPE specific filter. Shaped pulses are sent to a Digital Signal Processing (DSP) unit for event processing. The DSP unit has 100 MHz Analog-to-Digital Converters on the front-end which send digitized samples to Field Programmable Gate Arrays which are programmed via user configurable algorithms to process PET coincidence events or bioluminescence SPEs. Information determined using DSP includes: event timing, energy determination-discrimination, position determination-lookup, and coincidence processing. Coincidence or SPE events are recorded to an external disk and minimal post processing is required prior to image reconstruction. Initial imaging results from a phantom filled with

Keywords: Bioluminescence; optical imaging; positron emission tomography; small animal imaging

References

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Grant support