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Winkler BS, Oltmer F, Richter J, et al. CK1δ in lymphoma: gene expression and mutation analyses and validation of CK1δ kinase activity for therapeutic application. Front Cell Dev Biol. 2015;3:9doi: 10.3389/fcell.2015.00009.
Winkler, B. S., Oltmer, F., Richter, J., Bischof, J., Xu, P., Burster, T., Leithäuser, F., & Knippschild, U. (2015). CK1δ in lymphoma: gene expression and mutation analyses and validation of CK1δ kinase activity for therapeutic application. Frontiers in cell and developmental biology, 39. https://doi.org/10.3389/fcell.2015.00009
Winkler, B Sophia, et al. "CK1δ in lymphoma: gene expression and mutation analyses and validation of CK1δ kinase activity for therapeutic application." Frontiers in cell and developmental biology vol. 3 (2015): 9. doi: https://doi.org/10.3389/fcell.2015.00009
Winkler BS, Oltmer F, Richter J, Bischof J, Xu P, Burster T, Leithäuser F, Knippschild U. CK1δ in lymphoma: gene expression and mutation analyses and validation of CK1δ kinase activity for therapeutic application. Front Cell Dev Biol. 2015 Feb 20;3:9. doi: 10.3389/fcell.2015.00009. eCollection 2015. PMID: 25750912; PMCID: PMC4335261.
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Front Cell Dev Biol. 2015 Feb 20;3:9. doi: 10.3389/fcell.2015.00009. eCollection 2015.

CK1δ in lymphoma: gene expression and mutation analyses and validation of CK1δ kinase activity for therapeutic application.

Frontiers in cell and developmental biology

B Sophia Winkler, Franziska Oltmer, Julia Richter, Joachim Bischof, Pengfei Xu, Timo Burster, Frank Leithäuser, Uwe Knippschild

Affiliations

  1. Department of Pathology, Ulm University Hospital Ulm, Germany.
  2. Department of General and Visceral Surgery, Surgery Center, Ulm University Hospital Ulm, Germany.
  3. Department of Neurosurgery, Ulm University Hospital Ulm, Germany.

PMID: 25750912 PMCID: PMC4335261 DOI: 10.3389/fcell.2015.00009

Abstract

The prognosis of lymphoid neoplasms has improved considerably during the last decades. However, treatment response for some lymphoid neoplasms is still poor, indicating the need for new therapeutic approaches. One promising new strategy is the inhibition of kinases regulating key signal transduction pathways, which are of central importance in tumorigenesis. Kinases of the CK1 family may represent an attractive drug target since CK1 expression and/or activity are associated with the pathogenesis of malignant diseases. Over the last years efforts were taken to develop highly potent and selective CK1-specific inhibitor compounds and their therapeutic potential has now to be proved in pre-clinical trials. Therefore, we analyzed expression and mutational status of CK1δ in several cell lines representing established lymphoma entities, and also measured the mRNA expression level in primary lymphoma tissue as well as in non-neoplastic blood cells. For a selection of lymphoma cell lines we furthermore determined CK1δ kinase activity and demonstrated therapeutic potential of CK1-specific inhibitors as a putative therapeutic option in the treatment of lymphoid neoplasms.

Keywords: CK1; cell cycle; inhibitor; lymphoma; mutation analysis; therapy

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