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Med Chem Res. 2015;24:372-382. doi: 10.1007/s00044-014-1130-x. Epub 2014 Jul 15.

QSPR analysis of some agonists and antagonists of α-adrenergic receptors.

Medicinal chemistry research : an international journal for rapid communications on design and mechanisms of action of biologically active agents

Piotr Kawczak, Leszek Bober, Tomasz Bączek

Affiliations

  1. Department of Pharmaceutical Chemistry, Medical University of Gdansk, 80-416 Gda?sk, Poland.
  2. POLPHARMA SA Pharmaceutical Works, 83-200 Starogard Gda?ski, Poland.
  3. Department of Pharmaceutical Chemistry, Medical University of Gdansk, 80-416 Gda?sk, Poland ; Division of Human Anatomy and Physiology, Institute of Health Sciences, Pomeranian University of S?upsk, 76-200 S?upsk, Poland.

PMID: 25589825 PMCID: PMC4284397 DOI: 10.1007/s00044-014-1130-x

Abstract

Thirty-three compounds belonging to the sympatholytics and sympathomimetics were analyzed during the study. The biological activity data for the parameters of binding affinity to the α

Keywords: Adrenergic receptors; Agonists; Antagonists; FA; PCA; RP-LC

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