Display options
Cite
Galeano P, Blanco E, Logica Tornatore TM, et al. Life-long environmental enrichment counteracts spatial learning, reference and working memory deficits in middle-aged rats subjected to perinatal asphyxia. Front Behav Neurosci. 2015;8:406doi: 10.3389/fnbeh.2014.00406.
Galeano, P., Blanco, E., Logica Tornatore, T. M., Romero, J. I., Holubiec, M. I., Rodríguez de Fonseca, F., & Capani, F. (2014). Life-long environmental enrichment counteracts spatial learning, reference and working memory deficits in middle-aged rats subjected to perinatal asphyxia. Frontiers in behavioral neuroscience, 8406. https://doi.org/10.3389/fnbeh.2014.00406
Galeano, Pablo, et al. "Life-long environmental enrichment counteracts spatial learning, reference and working memory deficits in middle-aged rats subjected to perinatal asphyxia." Frontiers in behavioral neuroscience vol. 8 (2014): 406. doi: https://doi.org/10.3389/fnbeh.2014.00406
Galeano P, Blanco E, Logica Tornatore TM, Romero JI, Holubiec MI, Rodríguez de Fonseca F, Capani F. Life-long environmental enrichment counteracts spatial learning, reference and working memory deficits in middle-aged rats subjected to perinatal asphyxia. Front Behav Neurosci. 2015 Jan 05;8:406. doi: 10.3389/fnbeh.2014.00406. eCollection 2014. PMID: 25601829; PMCID: PMC4283640.
Copy Download .nbib Format: NLM
Share it on

Front Behav Neurosci. 2015 Jan 05;8:406. doi: 10.3389/fnbeh.2014.00406. eCollection 2014.

Life-long environmental enrichment counteracts spatial learning, reference and working memory deficits in middle-aged rats subjected to perinatal asphyxia.

Frontiers in behavioral neuroscience

Pablo Galeano, Eduardo Blanco, Tamara M A Logica Tornatore, Juan I Romero, Mariana I Holubiec, Fernando Rodríguez de Fonseca, Francisco Capani

Affiliations

  1. Facultad de Medicina, Instituto de Investigaciones Cardiológicas "Prof. Dr. Alberto C. Taquini" (ININCA), Universidad de Buenos Aires (CONICET) Buenos Aires, Argentina ; Instituto de Investigaciones Bioquímicas de Buenos Aires (CONICET), Fundación Instituto Leloir Buenos Aires, Argentina.
  2. Facultad de Medicina, Instituto de Investigaciones Cardiológicas "Prof. Dr. Alberto C. Taquini" (ININCA), Universidad de Buenos Aires (CONICET) Buenos Aires, Argentina ; Laboratorio de Investigación, Instituto de Investigación Biomédica (IBIMA), Universidad de Málaga - Hospital Regional Universitario de Málaga (UGC Salud Mental) Málaga, Spain ; Departamento de Psicobiología y Metodología de las Ciencias del Comportamiento, Facultad de Psicología, Instituto de Investigación Biomédica (IBIMA), Universidad de Málaga Málaga, Spain.
  3. Facultad de Medicina, Instituto de Investigaciones Cardiológicas "Prof. Dr. Alberto C. Taquini" (ININCA), Universidad de Buenos Aires (CONICET) Buenos Aires, Argentina.
  4. Laboratorio de Investigación, Instituto de Investigación Biomédica (IBIMA), Universidad de Málaga - Hospital Regional Universitario de Málaga (UGC Salud Mental) Málaga, Spain.

PMID: 25601829 PMCID: PMC4283640 DOI: 10.3389/fnbeh.2014.00406

Abstract

Continuous environmental stimulation induced by exposure to enriched environment (EE) has yielded cognitive benefits in different models of brain injury. Perinatal asphyxia results from a lack of oxygen supply to the fetus and is associated with long-lasting neurological deficits. However, the effects of EE in middle-aged rats suffering perinatal asphyxia are unknown. Therefore, the aim of the present study was to assess whether life-long exposure to EE could counteract the cognitive and behavioral alterations in middle-aged asphyctic rats. Experimental groups consisted of rats born vaginally (CTL), by cesarean section (C+), or by C+ following 19 min of asphyxia at birth (PA). At weaning, rats were assigned to standard (SE) or enriched environment (EE) for 18 months. During the last month of housing, animals were submitted to a behavioral test battery including Elevated Plus Maze, Open Field, Novel Object Recognition and Morris water maze (MWM). Results showed that middle-aged asphyctic rats, reared in SE, exhibited an impaired performance in the spatial reference and working memory versions of the MWM. EE was able to counteract these cognitive impairments. Moreover, EE improved the spatial learning performance of middle-aged CTL and C+ rats. On the other hand, all groups reared in SE did not differ in locomotor activity and anxiety levels, while EE reduced locomotion and anxiety, regardless of birth condition. Recognition memory was altered neither by birth condition nor by housing environment. These results support the importance of environmental stimulation across the lifespan to prevent cognitive deficits induced by perinatal asphyxia.

Keywords: aging; anxiety; environmental enrichment; habituation; perinatal asphyxia; recognition memory; spatial reference memory; spatial working memory

References

  1. Behav Genet. 1999 Jan;29(1):41-6 - PubMed
  2. Exp Neurol. 2006 May;199(1):113-21 - PubMed
  3. Behav Brain Res. 1988 Nov 1;31(1):47-59 - PubMed
  4. Learn Mem. 2012 Sep 14;19(10):444-8 - PubMed
  5. Neurobiol Learn Mem. 2006 Mar;85(2):139-52 - PubMed
  6. Exp Gerontol. 2005 Jun;40(6):506-11 - PubMed
  7. Exp Neurol. 1996 May;139(1):25-33 - PubMed
  8. Behav Brain Res. 2007 Dec 3;184(2):117-23 - PubMed
  9. J Psychiatr Res. 1987;21(4):413-21 - PubMed
  10. Curr Neurovasc Res. 2010 Nov;7(4):268-80 - PubMed
  11. Nat Neurosci. 2000 Mar;3(3):238-44 - PubMed
  12. Eur J Neurosci. 2005 Jan;21(2):513-21 - PubMed
  13. Physiol Behav. 2014 Apr 22;129:118-29 - PubMed
  14. Behav Brain Res. 2007 Jan 25;176(2):267-73 - PubMed
  15. Brain Res. 1991 Mar 8;543(1):1-9 - PubMed
  16. Neurobiol Learn Mem. 2008 Oct;90(3):511-8 - PubMed
  17. Behav Brain Res. 2005 Aug 30;163(1):78-90 - PubMed
  18. Front Behav Neurosci. 2014 Sep 16;8:321 - PubMed
  19. Learn Mem. 2001 Jan-Feb;8(1):26-34 - PubMed
  20. Gerontology. 2004 Jul-Aug;50(4):200-5 - PubMed
  21. Nat Rev Neurosci. 2000 Dec;1(3):191-8 - PubMed
  22. Brain Res. 2001 Sep 28;914(1-2):204-7 - PubMed
  23. Semin Perinatol. 2004 Aug;28(4):249-56 - PubMed
  24. Int J Neurosci. 2003 May;113(5):641-54 - PubMed
  25. Synapse. 2013 Sep;67(9):553-67 - PubMed
  26. Cell Mol Life Sci. 2002 Mar;59(3):519-26 - PubMed
  27. Nat Rev Neurosci. 2006 Sep;7(9):697-709 - PubMed
  28. Behav Brain Res. 2006 May 15;169(2):294-302 - PubMed
  29. Brain Res Bull. 2013 Sep;98:1-9 - PubMed
  30. Nat Med. 1999 Apr;5(4):448-53 - PubMed
  31. Neural Plast. 2012;2012:873532 - PubMed
  32. Behav Brain Res. 1996 Jun;78(1):57-65 - PubMed
  33. J Chem Neuroanat. 2000 Oct;20(1):71-82 - PubMed
  34. Eur J Pediatr. 2007 Jul;166(7):645-54 - PubMed
  35. Exp Neurol. 2000 Jul;164(1):45-52 - PubMed
  36. Nat Protoc. 2006;1(2):848-58 - PubMed
  37. Neurobiol Learn Mem. 2007 Jan;87(1):101-8 - PubMed
  38. Behav Neurosci. 2010 Oct;124(5):559-73 - PubMed
  39. Brain Res. 1997 Nov 14;775(1-2):11-23 - PubMed
  40. Eur J Neurosci. 2004 Apr;19(8):2288-98 - PubMed
  41. Ann Neurol. 1981 Feb;9(2):131-41 - PubMed
  42. Behav Brain Res. 2008 Mar 5;187(2):304-11 - PubMed
  43. Behav Brain Res. 1992 Nov 30;52(1):49-59 - PubMed
  44. Behav Brain Res. 2010 Dec 31;215(2):244-54 - PubMed
  45. Int J Dev Neurosci. 2011 Oct;29(6):609-19 - PubMed
  46. Neurobiol Learn Mem. 2014 Oct;114:16-25 - PubMed
  47. Exp Neurol. 2009 Oct;219(2):404-13 - PubMed
  48. Exp Neurol. 2010 Jun;223(2):615-22 - PubMed
  49. Neuroscience. 2014 Jun 13;270:76-87 - PubMed
  50. Ann Neurol. 2002 Aug;52(2):135-43 - PubMed
  51. Brain Res. 2008 Jul 7;1218:257-66 - PubMed
  52. Clin Evid. 2006 Jun;(15):511-9 - PubMed
  53. Exp Gerontol. 2011 Apr;46(4):309-15 - PubMed
  54. Neurochem Int. 2008 May;52(6):1198-203 - PubMed
  55. Neurosci Lett. 1994 Jul 4;175(1-2):9-12 - PubMed
  56. Am J Psychiatry. 2002 Jul;159(7):1080-92 - PubMed
  57. Neuropsychopharmacology. 2010 Jul;35(8):1664-73 - PubMed
  58. Neuroscience. 2013 Mar 27;234:116-24 - PubMed
  59. Neurosci Lett. 1992 Apr 13;138(1):153-6 - PubMed
  60. Neurobiol Learn Mem. 2011 Sep;96(2):121-9 - PubMed
  61. Brain Res. 2009 Jan 9;1247:188-95 - PubMed
  62. Pharmacol Biochem Behav. 2010 Feb;94(4):534-42 - PubMed
  63. Brain Res Rev. 2007 Aug;55(1):78-88 - PubMed

Publication Types