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Iovino F, Orditura M, Auriemma PP, et al. Vertebral carcinomatosis eleven years after advanced gastric cancer resection: A case report. Oncol Lett. 2014;9(3):1403-1405doi: 10.3892/ol.2014.2822.
Iovino, F., Orditura, M., Auriemma, P. P., Ciorra, F. R., Giordano, G., Orabona, C., Bara, F., Sergio, R., Savastano, B., Fabozzi, A., Laterza, M. M., Ventriglia, J., Petrillo, A., Della Corte, C. M., & DE Vita, F. (2015). Vertebral carcinomatosis eleven years after advanced gastric cancer resection: A case report. Oncology letters, 9(3), 1403-1405. https://doi.org/10.3892/ol.2014.2822
Iovino, Francesco, et al. "Vertebral carcinomatosis eleven years after advanced gastric cancer resection: A case report." Oncology letters vol. 9,3 (2015): 1403-1405. doi: https://doi.org/10.3892/ol.2014.2822
Iovino F, Orditura M, Auriemma PP, Ciorra FR, Giordano G, Orabona C, Bara F, Sergio R, Savastano B, Fabozzi A, Laterza MM, Ventriglia J, Petrillo A, Della Corte CM, DE Vita F. Vertebral carcinomatosis eleven years after advanced gastric cancer resection: A case report. Oncol Lett. 2015 Mar;9(3):1403-1405. doi: 10.3892/ol.2014.2822. Epub 2014 Dec 23. PMID: 25663920; PMCID: PMC4315078.
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Oncol Lett. 2015 Mar;9(3):1403-1405. doi: 10.3892/ol.2014.2822. Epub 2014 Dec 23.

Vertebral carcinomatosis eleven years after advanced gastric cancer resection: A case report.

Oncology letters

Francesco Iovino, Michele Orditura, Pasquale Pio Auriemma, Francesca Romana Ciorra, Giovanni Giordano, Consiglia Orabona, Francesco Bara, Renato Sergio, Beatrice Savastano, Alessio Fabozzi, Maria Maddalena Laterza, Jole Ventriglia, Angelica Petrillo, Carminia Maria Della Corte, Ferdinando DE Vita

Affiliations

  1. IX Division of General Surgery, Department of Anaesthetic, Surgical and Emergency Sciences, Second University of Naples, Naples I-80131, Italy.
  2. Division of Medical Oncology, 'F. Magrassi - A. Lanzara' Department of Clinical and Experimental Medicine, Second University of Naples School of Medicine, Naples I-80131, Italy.

PMID: 25663920 PMCID: PMC4315078 DOI: 10.3892/ol.2014.2822

Abstract

Bone metastasis is an uncommon event in advanced gastric cancer patients and bone metastases are rarely detected as isolated lesions. However, eleven years after treatment for locally advanced gastric cancer, including total gastrectomy followed by adjuvant chemotherapy, a 49-year-old female was admitted to the IX Division of General Surgery of the Second University of Naples (Naples, Italy) exhibiting severe progressive neurological symptoms. Magnetic resonance imaging indicated vertebral abnormalities, with evidence of marrow infiltration in several vertebral bodies; however, a contrast-enhanced computed tomography scan did not detect disease progression to other sites. Biopsy of the soft tissue at the level of the second lumbar vertebra (L2) revealed a metastatic lesion derived from gastric mucinous adenocarcinoma. The patient was initially treated with radiotherapy directed to the L2-L4 vertebral bodies to control the pain. Subsequently, systemic chemotherapy according to a FOLFOX-4 (leucovorin, fluorouracil and oxaliplatin) regimen commenced. However, after eight cycles, pulmonary progression of the disease occurred. Thus, palliative care was administered and the patient succumbed one month later. The late relapse of gastric cancer in the current patient may be associated with the theory of tumour dormancy.

Keywords: gastric cancer; tumour dormancy; vertebral metastases

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