Display options
Cite
Li J, Yang CH. Improvement of preoperative management in patients with adrenal pheochromocytoma. Int J Clin Exp Med. 2014;7(12):5541-6
Li, J., & Yang, C. H. (2014). Improvement of preoperative management in patients with adrenal pheochromocytoma. International journal of clinical and experimental medicine, 7(12), 5541-6.
Li, Jiang, and Yang, Chang-Hai. "Improvement of preoperative management in patients with adrenal pheochromocytoma." International journal of clinical and experimental medicine vol. 7,12 (2014): 5541-6.
Li J, Yang CH. Improvement of preoperative management in patients with adrenal pheochromocytoma. Int J Clin Exp Med. 2014 Dec 15;7(12):5541-6. eCollection 2014. PMID: 25664068; PMCID: PMC4307515.
Copy Download .nbib Format: NLM
Share it on

Int J Clin Exp Med. 2014 Dec 15;7(12):5541-6. eCollection 2014.

Improvement of preoperative management in patients with adrenal pheochromocytoma.

International journal of clinical and experimental medicine

Jiang Li, Chang-Hai Yang

Affiliations

  1. Department of Urology, Tianjin Medical University General Hospital 154 Anshan Road, Heping District, Tianjin 300052, China.

PMID: 25664068 PMCID: PMC4307515

Abstract

OBJECTIVE: To investigate methods for improving the preoperative management of patients with pheochromocytoma.

METHODS: We collected 155 cases diagnosed as adrenal pheochromocytoma and with hypertension. During preoperative preparation, 85 patients had antihypertensive therapy by using the selective α1-blocker doxazosin controlled-release tablets; 70 patients was controlled by using the nonselective α-blocker phenoxybenzamine; All 155 patients underwent qualitative diagnosis by determination of 24-hour urinary vanilmandelic acid (VMA) or [11C]meta-hydroxyephedrine (mHED) positron emission tomography computed tomography (PET-CT) and underwent computed tomography (CT) for tumor localization;

RESULTS: In doxazosin group, with the exception of two patients who had radical fluctuations in blood pressure during surgery, other patients showed a smooth blood pressure control during surgery. No hypertensive crisis and hypotensive shock appeared after surgery. In phenoxybenzamine group, ten patients had sharp fluctuations in blood pressure during surgery, and no hypertensive crisis and hypotensive shock appeared after surgery.

CONCLUSION: Compared with phenoxybenzamine, doxazosin has minimal adverse reactions, with high security as a preoperative preparation for adrenal pheochromocytoma, and it is easy to be taken. MHED PET-CT examination has a clear diagnostic value for patients with normal 24-hour urinary VMA.

Keywords: Adrenal; doxazosin controlled-release tablets; perioperative period; phenoxybenzamine; pheochromocytoma

References

  1. Eur J Endocrinol. 1999 Dec;141(6):619-24 - PubMed
  2. Endocrine. 2014 Apr;45(3):469-78 - PubMed
  3. Endocr Pract. 2013 May-Jun;19(3):e74-6 - PubMed
  4. World J Surg. 2002 Aug;26(8):1037-42 - PubMed
  5. Am Surg. 2013 Nov;79(11):1196-202 - PubMed
  6. World J Surg. 2014 Mar;38(3):716-23 - PubMed
  7. Urology. 2010 Aug;76(2):508.e6-11 - PubMed
  8. Eur J Anaesthesiol. 2008 Jun;25(6):508-10 - PubMed
  9. Endocr Rev. 2003 Aug;24(4):539-53 - PubMed
  10. G Chir. 2010 Jun-Jul;31(6-7):332-5 - PubMed
  11. Am Heart J. 1988 Dec;116(6 Pt 2):1785-9 - PubMed

Publication Types