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World J Nephrol. 2015 Feb 06;4(1):92-7. doi: 10.5527/wjn.v4.i1.92.

Increasing the use of biocompatible, glucose-free peritoneal dialysis solutions.

World journal of nephrology

Ahad Qayyum, Elizabeth Ley Oei, Klara Paudel, Stanley L Fan

Affiliations

  1. Ahad Qayyum, Klara Paudel, Stanley L Fan, Department of Renal Medicine and Transplantation, The Royal London Hospital, Barts Health NHS Trust, London E1 1BB, United Kingdom.

PMID: 25664250 PMCID: PMC4317632 DOI: 10.5527/wjn.v4.i1.92

Abstract

A major concern inhibiting some clinicians from embracing peritoneal dialysis (PD) as the preferred first modality of dialysis is the effects of PD solutions on the peritoneal membrane. These anatomical and functional changes predispose to complications like peritonitis, encapsulating peritoneal sclerosis and ultrafiltration failure. In recent years, "biocompatible" and glucose-sparing PD regimens have been developed to minimize damage to the peritoneal membrane. Can the use of these more expensive solutions be justified on current evidence? In this review of the literature, we explore how we may individualize the prescription of biocompatible PD fluid.

Keywords: Biocompatibility; Glucose degradation products; Individualized prescription; Peritoneal dialysis; Peritonitis; Residual renal function; Ultrafiltration failure

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