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Zh Nevrol Psikhiatr Im S S Korsakova. 2014;114(10):6-11.

[Effects of ecological characteristics of place of residence on the incidence, prevalence and risk of multiple sclerosis in the Republic North Ossetia - Alania].

Zhurnal nevrologii i psikhiatrii imeni S.S. Korsakova

[Article in Russian]
M A Khodova, S A Sivertseva, N F Smirnova, E I Gusev, A N Boĭko

Affiliations

  1. Kafedra nevrologii, ne?rokhirurgii i meditsinsko? genetiki lechebnogo fakul'teta GOU VPO "Rossi?ski? nauchno-issledovatel'ski? meditsinski? universitet im. N.I. Pirogova" Minzdrava Rossii; Otdelenie nevrologii Gorodsko? klinichesko? i bol'nitsy Vladikavkaza, Respublika Severnaia Osetiia - Alaniia, Vladikavkaz.
  2. GBOU VPO "Tiumenskaia gosudarstvennaia meditsinskaia akademiia" Minzdrava Rossii, Tiumenski? tsentr rasseiannogo skleroza, MSCh "Neftianik", Tiumen'
  3. Kafedra nevrologii, ne?rokhirurgii i meditsinsko? genetiki lechebnogo fakul'teta GOU VPO "Rossi?ski? nauchno-issledovatel'ski? meditsinski? universitet im. N.I. Pirogova" Minzdrava Rossii.

PMID: 25591529

Abstract

Objective. To study the relationship between characteristics of place of residence and epidemiological indicators of multiple sclerosis (MS) in the Republic North Ossetia - Alania. Material and methods. We present the data on the effects of environmental characteristics of place of residence on the incidence, prevalence and risk of MS. Data of 110 MS patients and matched controls have been analyzed. Results. Ecological characteristics of place of residence of MS patients differ significantly from those of controls. The prevalence and incidence of MS increase in patients who have moved from presumably pollution free areas to the places with high population density and plant facilities. Conclusion. MS is thought to be a disease caused by the interaction of genetic susceptibility and environmental factors. Risk factors are intoxication with heavy metal and chemical compounds and living in environmentally disadvantaged areas.

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