Display options
Cite
Leary SD, Lawlor DA, Davey Smith G, et al. Behavioural early-life exposures and body composition at age 15 years. Nutr Diabetes. 2015;5:e150doi: 10.1038/nutd.2014.47.
Leary, S. D., Lawlor, D. A., Davey Smith, G., Brion, M. J., & Ness, A. R. (2015). Behavioural early-life exposures and body composition at age 15 years. Nutrition & diabetes, 5e150. https://doi.org/10.1038/nutd.2014.47
Leary, S D, et al. "Behavioural early-life exposures and body composition at age 15 years." Nutrition & diabetes vol. 5 (2015): e150. doi: https://doi.org/10.1038/nutd.2014.47
Leary SD, Lawlor DA, Davey Smith G, Brion MJ, Ness AR. Behavioural early-life exposures and body composition at age 15 years. Nutr Diabetes. 2015 Feb 09;5:e150. doi: 10.1038/nutd.2014.47. PMID: 25664839; PMCID: PMC4338416.
Copy Download .nbib Format: NLM
Share it on

Nutr Diabetes. 2015 Feb 09;5:e150. doi: 10.1038/nutd.2014.47.

Behavioural early-life exposures and body composition at age 15 years.

Nutrition & diabetes

S D Leary, D A Lawlor, G Davey Smith, M J Brion, A R Ness

Affiliations

  1. Biomedical Research Unit in Nutrition, Diet and Lifestyle, School of Oral and Dental Sciences, University of Bristol, Bristol, UK.
  2. Medical Research Council Centre for Causal Analyses in Translational Epidemiology, School of Social and Community Medicine, University of Bristol, Bristol, UK.

PMID: 25664839 PMCID: PMC4338416 DOI: 10.1038/nutd.2014.47

Abstract

BACKGROUND/OBJECTIVES: Previous studies have demonstrated associations between some early-life exposures and later obesity, but most have used body mass index in childhood or adulthood as the outcome. The objective of this study was to investigate whether early-life exposures were associated with directly measured fat and lean mass in adolescence.

SUBJECTS/METHODS: This study used data on 4750 mother-offspring pairs, collected as a part of the Avon Longitudinal Study of Parents and Children, Bristol, UK between 1991 and 1992; associations between behavioural exposures occurring from conception up to 5 years of age (maternal and paternal smoking during pregnancy, breastfeeding, age at introduction to solids, dietary patterns and physical inactivity during early childhood) and offspring body composition measured by dual-energy X-ray absorptiometry at ~15 years were assessed.

RESULTS: After full adjustment for potential confounders, maternal smoking during pregnancy, having a junk food diet and spending more time watching television in early childhood were all associated with higher fat mass at age 15, whereas maternal smoking, having a healthy diet and playing computer games more frequently in early childhood were all associated with a higher lean mass at age 15. Associations with paternal smoking were generally weaker for both fat and lean mass, but as there was no strong statistical evidence for maternal vs paternal differences, confounding by social factors rather than a direct effect of maternal smoking cannot be ruled out. Early feeding was not associated with fat or lean mass at age 15.

CONCLUSIONS: This study does not provide compelling evidence for associations between most early-life factors and body composition in adolescence. However, possible associations with dietary patterns and physical inactivity in early childhood require further investigation in other cohorts that have direct measurements of adolescent body composition.

References

  1. Annu Rev Public Health. 2001;22:337-53 - PubMed
  2. Obes Res. 1999 Sep;7(5):431-7 - PubMed
  3. Obes Rev. 2010 Oct;11(10):695-708 - PubMed
  4. Eur J Clin Nutr. 2000 Jan;54(1):73-80 - PubMed
  5. Eur J Clin Nutr. 2012 Dec;66(12):1329-34 - PubMed
  6. Matern Child Nutr. 2013 Jan;9 Suppl 1:105-19 - PubMed
  7. Am J Clin Nutr. 2007 Jun;85(6):1578-85 - PubMed
  8. J Nutr. 2009 Feb;139(2):417S-21S - PubMed
  9. BMJ. 2003 Oct 18;327(7420):901 - PubMed
  10. Am J Public Health. 1994 Jul;84(7):1086-93 - PubMed
  11. Clin Endocrinol Metab. 1986 Aug;15(3):411-51 - PubMed
  12. Ann Nutr Metab. 2012;60 Suppl 2:8-20 - PubMed
  13. J Clin Endocrinol Metab. 2008 Dec;93(12):4576-99 - PubMed
  14. Int J Epidemiol. 2011 Jun;40(3):670-80 - PubMed
  15. Br J Nutr. 1994 Oct;72(4):619-43 - PubMed
  16. Drug Alcohol Depend. 2014 Jun 1;139:159-63 - PubMed
  17. BMJ. 2005 Jun 11;330(7504):1357 - PubMed
  18. Paediatr Perinat Epidemiol. 2001 Jan;15(1):74-87 - PubMed
  19. Hum Biol. 2000 Jun;72(3):447-54 - PubMed
  20. Pediatrics. 2009 Jan;123(1):e67-73 - PubMed
  21. Arch Dis Child. 2001 Jul;85(1):67-72 - PubMed
  22. Obesity (Silver Spring). 2006 Dec;14(12):2284-93 - PubMed
  23. JAMA. 2010 Jan 20;303(3):275-6 - PubMed
  24. Basic Clin Pharmacol Toxicol. 2008 Feb;102(2):245-56 - PubMed

Publication Types

Grant support