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Mallick S, Kumar Pradhan S, Chandran M, et al. Study of particle rearrangement, compression behavior and dissolution properties after melt dispersion of ibuprofen, Avicel and Aerosil. Results Pharma Sci. 2011;1(1):1-10doi: 10.1016/j.rinphs.2011.05.003.
Mallick, S., Kumar Pradhan, S., Chandran, M., Acharya, M., Digdarsini, T., & Mohapatra, R. (2011). Study of particle rearrangement, compression behavior and dissolution properties after melt dispersion of ibuprofen, Avicel and Aerosil. Results in pharma sciences, 1(1), 1-10. https://doi.org/10.1016/j.rinphs.2011.05.003
Mallick, Subrata, et al. "Study of particle rearrangement, compression behavior and dissolution properties after melt dispersion of ibuprofen, Avicel and Aerosil." Results in pharma sciences vol. 1,1 (2011): 1-10. doi: https://doi.org/10.1016/j.rinphs.2011.05.003
Mallick S, Kumar Pradhan S, Chandran M, Acharya M, Digdarsini T, Mohapatra R. Study of particle rearrangement, compression behavior and dissolution properties after melt dispersion of ibuprofen, Avicel and Aerosil. Results Pharma Sci. 2011 May 17;1(1):1-10. doi: 10.1016/j.rinphs.2011.05.003. eCollection 2011 May. PMID: 25755976; PMCID: PMC4150624.
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Results Pharma Sci. 2011 May 17;1(1):1-10. doi: 10.1016/j.rinphs.2011.05.003. eCollection 2011 May.

Study of particle rearrangement, compression behavior and dissolution properties after melt dispersion of ibuprofen, Avicel and Aerosil.

Results in pharma sciences

Subrata Mallick, Saroj Kumar Pradhan, Muronia Chandran, Manoj Acharya, Tanmayee Digdarsini, Rajaram Mohapatra

Affiliations

  1. Department of Pharmaceutics, School of Pharmaceutical Sciences, Siksha 'O' Anusandhan University, Kalinganagar, Bhubaneswar 751003, Orissa, India.
  2. Department of Pharmaceutics, College of Pharmaceutical Sciences, Berhampur, Mohuda, Orissa, India.

PMID: 25755976 PMCID: PMC4150624 DOI: 10.1016/j.rinphs.2011.05.003

Abstract

Particle rearrangements, compaction under pressure and in vitro dissolution have been evaluated after melt dispersion of ibuprofen, Avicel and Aerosil. The Cooper-Eaton and Kuno equations were utilized for the determination of particle rearrangement and compression behavior from tap density and compact data. Particle rearrangement could be divided into two stages as primary and secondary rearrangement. Transitional tapping between the stages was found to be 20-25 taps in ibuprofen crystalline powder, which was increased up to 45 taps with all formulated powders. Compaction in the rearrangement stages was increased in all the formulations with respect to pure ibuprofen. Significantly increased compaction of ibuprofen under pressure can be achieved using Avicel by melt dispersion technique, which could be beneficial in ibuprofen tablet manufacturing by direct compression. SEM, FTIR and DSC have been utilized for physicochemical characterization of the melt dispersion powder materials. Dissolution of ibuprofen from compacted tablet of physical mixture and melt dispersion particles has also been improved greatly in the following order: Ibc

Keywords: Aerosil lubricated mcc; Compression behavior; Ibuprofen; In vitro dissolution; Melt dispersion; Particle rearrangement

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