Trends Dev Biol. 2014;8:17-37.
On the evolution of development.
Trends in developmental biology
John S Torday
Affiliations
Affiliations
- Department of Pediatrics, Harbor-UCLA Medical Center, 1124 W.Carson Street, Torrance, California 90502-2006, USA.
PMID: 25729239
PMCID: PMC4339279
Abstract
Perhaps development is more than just morphogenesis. We now recognize that the conceptus expresses epigenetic marks that heritably affect it phenotypically, indicating that the offspring are to some degree genetically autonomous, and that ontogeny and phylogeny may coordinately determine the fate of such marks. This scenario mechanistically links ecology, ontogeny and phylogeny together as an integrated mechanism for evolution for the first time. As a functional example, the Parathyroid Hormone-related Protein (PTHrP) signaling duplicated during the Phanerozoic water-land transition. The PTHrP signaling pathway was critical for the evolution of the skeleton, skin barrier, and lung function, based on experimental evidence, inferring that physiologic stress can profoundly affect adaptation through internal selection, giving seminal insights to how and why vertebrates were able to evolve from water to land. By viewing evolution from its inception in unicellular organisms, driven by competition between pro- and eukaryotes, the emergence of complex biologic traits from the unicellular cell membrane offers a novel way of thinking about the process of evolution from its beginnings, rather than from its consequences as is traditionally done. And by focusing on the epistatic balancing mechanisms for calcium and lipid homeostasis, the evolution of unicellular organisms, driven by competition between pro- and eukaryotes, gave rise to the emergence of complex biologic traits derived from the unicellular plasma lemma, offering a unique way of thinking about the process of evolution. By exploiting the cellular-molecular mechanisms of lung evolution as ontogeny and phylogeny, the sequence of events for the evolution of the skin, kidney and skeleton become more transparent. This novel approach to the evolution question offers equally novel insights to the primacy of the unicellular state, hologenomics and even
Keywords: Parathyroid Hormone-related Protein; cell-cell signaling; evolution; growth factor signaling; homeostasis; homology; ontogeny; paracrine; phylogeny; unicellular state
References
- Am J Physiol. 1999 Oct;277(4 Pt 1):L848-59 - PubMed
- Exp Nephrol. 2001;9(6):436-43 - PubMed
- Am J Pathol. 2003 May;162(5):1495-502 - PubMed
- Lab Invest. 1995 Jul;73(1):59-63 - PubMed
- Reprod Fertil Dev. 2012;25(1):38-47 - PubMed
- Semin Perinatol. 1992 Apr;16(2):130-9 - PubMed
- Annu Rev Physiol. 1999;61:543-72 - PubMed
- Am Rev Respir Dis. 1983 Jun;127(6):763-70 - PubMed
- BMC Med. 2012 Oct 30;10:129 - PubMed
- Pediatr Pathol Mol Med. 2003 May-Jun;22(3):189-207 - PubMed
- Indian J Pediatr. 2006 Nov;73(11):1027-32 - PubMed
- Comp Biochem Physiol A Mol Integr Physiol. 2001 May;129(1):9-36 - PubMed
- Am J Physiol Lung Cell Mol Physiol. 2002 Mar;282(3):L405-10 - PubMed
- J Ultrasound Med. 2011 Nov;30(11):1573-85 - PubMed
- PPAR Res. 2012;2012:289867 - PubMed
- Anat Rec. 1978 Dec;192(4):467-79 - PubMed
- Anat Rec. 1992 Mar;232(3):432-43 - PubMed
- Exp Lung Res. 2011 Aug;37(6):376-86 - PubMed
- Am J Physiol Lung Cell Mol Physiol. 2002 Aug;283(2):L288-96 - PubMed
- Mol Biol Evol. 2011 Nov;28(11):2973-81 - PubMed
- Exp Nephrol. 1999 May-Jun;7(3):212-6 - PubMed
- Lung. 2009 Sep-Oct;187(5):281-9 - PubMed
- Cold Spring Harb Perspect Biol. 2012 Nov 01;4(11):null - PubMed
- Am J Physiol Lung Cell Mol Physiol. 2002 Jul;283(1):L130-5 - PubMed
- Pediatr Res. 2011 Nov;70(5):462-6 - PubMed
- Drugs Today (Barc). 2007 May;43(5):317-31 - PubMed
- J Biol Chem. 2009 Feb 6;284(6):4018-30 - PubMed
- Cold Spring Harb Perspect Med. 2012 Jan;2(1):a006429 - PubMed
- Exp Lung Res. 2006 Sep;32(8):379-93 - PubMed
- Allergy Asthma Immunol Res. 2013 Nov;5(6):343-7 - PubMed
- Am J Physiol Heart Circ Physiol. 2001 Jul;281(1):H60-6 - PubMed
- Physiol Genomics. 2009 Jun 10;38(1):1-6 - PubMed
- J Cell Biochem. 2003 Apr 15;88(6):1157-67 - PubMed
- J Invest Dermatol. 2006 Sep;126(9):2127-34 - PubMed
- Biochem Soc Trans. 2013 Jun;41(3):809-14 - PubMed
- Adv Anat Embryol Cell Biol. 2002;163:III-XII, 1-108 - PubMed
- J Anat. 2002 Oct;201(4):281-304 - PubMed
- Indian J Med Res. 2008 Mar;127(3):274-86 - PubMed
- Anat Rec. 2000 Feb 15;261(1):25-44 - PubMed
- Am J Physiol Lung Cell Mol Physiol. 2005 Jul;289(1):L60-6 - PubMed
- Mech Dev. 1994 Jul;47(1):29-42 - PubMed
- Am J Med Sci. 1998 Sep;316(3):205-8 - PubMed
- J Lipid Res. 1997 Nov;38(11):2249-63 - PubMed
- Am J Respir Cell Mol Biol. 1999 Feb;20(2):228-36 - PubMed
- Curr Probl Pediatr Adolesc Health Care. 2011 Jul;41(6):158-76 - PubMed
- Am J Physiol. 1998 Jan;274(1 Pt 1):L106-11 - PubMed
- Am J Respir Cell Mol Biol. 1989 Jul;1(1):65-74 - PubMed
- Integr Comp Biol. 2007 Oct;47(4):601-9 - PubMed
- Dev Biol. 2003 Jul 15;259(2):258-71 - PubMed
- Biol Neonate. 2006;89(2):109-19 - PubMed
- PLoS One. 2011;6(8):e24019 - PubMed
- Curr Opin Nephrol Hypertens. 1995 Sep;4(5):383-7 - PubMed
- Cell Biochem Biophys. 2003;37(3):235-46 - PubMed
- Am J Pathol. 1983 Dec;113(3):331-40 - PubMed
- Dev Biol. 2011 Nov 15;359(2):262-76 - PubMed
- J Biol Chem. 1999 Jun 11;274(24):16825-30 - PubMed
- J Biomech. 2010 Jan 5;43(1):108-18 - PubMed
- J Steroid Biochem Mol Biol. 2004 May;89-90(1-5):381-5 - PubMed
- Adv Space Res. 2003;32(8):1569-76 - PubMed
- Crit Care Clin. 1989 Apr;5(2):255-69 - PubMed
- Natl Cancer Inst Monogr. 1967 Sep;26:279-99 - PubMed
- Cell Mol Life Sci. 2011 Jan;68(1):1-13 - PubMed
- J Dairy Sci. 2008 Aug;91(8):3034-44 - PubMed
- Am J Physiol Lung Cell Mol Physiol. 2007 Mar;292(3):L608-11 - PubMed
- Pediatr Res. 2007 Jul;62(1):2-7 - PubMed
- J Steroid Biochem Mol Biol. 2013 Nov;138:72-80 - PubMed
- Perspect Biol Med. 2013 Autumn;56(4):455-84 - PubMed
- J Cell Physiol. 1984 Feb;118(2):113-23 - PubMed
- Clin Perinatol. 1992 Sep;19(3):521-39 - PubMed
- J Cell Mol Med. 2010 Apr;14(4):840-60 - PubMed
- J Huazhong Univ Sci Technolog Med Sci. 2009 Feb;29(1):39-44 - PubMed
- Respir Physiol Neurobiol. 2004 Dec 15;144(2-3):111-24 - PubMed
- Science. 2007 Apr 27;316(5824):557-8 - PubMed
- Med Hypotheses. 2009 May;72(5):596-602 - PubMed
- Biochim Biophys Acta. 1994 Aug 11;1223(1):91-100 - PubMed
- Respir Physiol Neurobiol. 2010 Aug 31;173 Suppl:S37-42 - PubMed
- Curr Opin Nephrol Hypertens. 1994 Jul;3(4):371-8 - PubMed
- Am J Respir Cell Mol Biol. 2007 Dec;37(6):640-50 - PubMed
- Adv Pharmacol. 2013;68:359-97 - PubMed
- J Leukoc Biol. 2010 Jan;87(1):79-92 - PubMed
- Fed Proc. 1979 Feb;38(2):215-23 - PubMed
- Birth Defects Res C Embryo Today. 2007 Sep;81(3):155-62 - PubMed
- Am J Respir Cell Mol Biol. 2004 Jul;31(1):8-12 - PubMed
- Lung. 2008 Mar-Apr;186(2):75-89 - PubMed
- Am J Physiol Cell Physiol. 2013 Oct 1;305(7):C682-9 - PubMed
- Antioxid Redox Signal. 2014 Nov 1;21(13):1893-904 - PubMed
- J Biol Chem. 2002 May 31;277(22):19374-81 - PubMed
- News Physiol Sci. 2003 Aug;18:151-7 - PubMed
- Eur Respir J. 2007 Jan;29(1):11-7 - PubMed
- Am J Med Sci. 1998 Sep;316(3):200-4 - PubMed
- Proc Natl Acad Sci U S A. 2006 Nov 14;103(46):17308-12 - PubMed
- Science. 1967 Dec 29;158(3809):1629-37 - PubMed
- Respir Physiol Neurobiol. 2004 Dec 15;144(2-3):125-39 - PubMed
- Integr Comp Biol. 2007 Oct;47(4):610-27 - PubMed
- Front Pediatr. 2014 Apr 28;2:34 - PubMed
- Pediatr Res. 2006 Oct;60(4):382-8 - PubMed
- Curr Med Chem. 2006;13(27):3239-52 - PubMed
- Am J Physiol Renal Physiol. 2012 Oct 15;303(8):F1157-65 - PubMed
- Biochim Biophys Acta. 1995 Jan 20;1254(2):198-206 - PubMed
- J Dairy Sci. 1996 Jul;79(7):1184-97 - PubMed
- Dev Dyn. 2004 Jun;230(2):278-89 - PubMed
- Am Rev Respir Dis. 1985 Dec;132(6):1307-12 - PubMed
- Anticancer Res. 2010 Jul;30(7):2755-67 - PubMed
- Biol Neonate. 2006;89(4):313-22 - PubMed
- Naturwissenschaften. 2010 Nov;97(11):951-69 - PubMed
- Pediatr Res. 2001 Jun;49(6):843-9 - PubMed
- Genes Dev. 1994 Feb 1;8(3):277-89 - PubMed
- Respir Physiol Neurobiol. 2006 Nov;154(1-2):118-38 - PubMed
- Biochim Biophys Acta. 2009 Jun;1791(6):419-40 - PubMed
- Vet Immunol Immunopathol. 2010 May 15;135(1-2):12-9 - PubMed
- Physiol Rev. 2005 Jul;85(3):811-44 - PubMed
- Nature. 2006 Apr 6;440(7085):757-63 - PubMed
- Dev Cell. 2014 Apr 28;29(2):135-8 - PubMed
- J Allergy Clin Immunol. 2003 Feb;111(2):215-25; quiz 226 - PubMed
- Reprod Fertil Dev. 2003;15(1-2):55-73 - PubMed
- Blood. 2006 Mar 1;107(5):1908-15 - PubMed
- J Cell Physiol. 2001 Nov;189(2):189-96 - PubMed
- Respir Physiol. 1992 Mar;87(3):325-48 - PubMed
- Am J Physiol Lung Cell Mol Physiol. 2011 Nov;301(5):L721-30 - PubMed
- J Invest Dermatol. 2002 Feb;118(2):275-81 - PubMed
- Respir Res. 2003;4:5 - PubMed
- Minerva Endocrinol. 2003 Jun;28(2):135-43 - PubMed
- BMC Evol Biol. 2012 Jul 06;12:110 - PubMed
Publication Types
Grant support