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Femminella GD, Ferrara N, Rengo G. The emerging role of microRNAs in Alzheimer's disease. Front Physiol. 2015;6:40doi: 10.3389/fphys.2015.00040.
Femminella, G. D., Ferrara, N., & Rengo, G. (2015). The emerging role of microRNAs in Alzheimer's disease. Frontiers in physiology, 640. https://doi.org/10.3389/fphys.2015.00040
Femminella, Grazia D, et al. "The emerging role of microRNAs in Alzheimer's disease." Frontiers in physiology vol. 6 (2015): 40. doi: https://doi.org/10.3389/fphys.2015.00040
Femminella GD, Ferrara N, Rengo G. The emerging role of microRNAs in Alzheimer's disease. Front Physiol. 2015 Feb 12;6:40. doi: 10.3389/fphys.2015.00040. eCollection 2015. PMID: 25729367; PMCID: PMC4325581.
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Front Physiol. 2015 Feb 12;6:40. doi: 10.3389/fphys.2015.00040. eCollection 2015.

The emerging role of microRNAs in Alzheimer's disease.

Frontiers in physiology

Grazia D Femminella, Nicola Ferrara, Giuseppe Rengo

Affiliations

  1. Department of Translational Medical Sciences, Federico II University Naples, Italy.
  2. "Salvatore Maugeri" Foundation - Istituto di Ricovero e Cura a Carattere Scientifico - Scientific Institute of Telese Terme Telese Terme, Italy.

PMID: 25729367 PMCID: PMC4325581 DOI: 10.3389/fphys.2015.00040

Abstract

MicroRNAs (miRNAs) are small non-coding RNA which have been shown to regulate gene expression. The alteration ofmiRNAs expression has been associated with several pathological processes, including neurodegeneration. In the search for easily accessible and non-invasive biomarkers for Alzheimer's disease (AD) diagnosis and prognosis, circulating miRNAs are among the most promising candidates. Some of them have been consistently identified as AD-specific miRNAs and their targets also seem implicated in pathophysiological processes underlying AD. Here, we review the emerging role for miRNA in AD, giving an overview on general miRNAs biology, their implications in AD pathophysiology and their potential role as future biomarkers.

Keywords: Alzheimer's disease; biomarker; functional recovery; gene expression; microRNAs; neurodegeneration

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