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Van Nuffel AM, Sukhatme V, Pantziarka P, et al. Repurposing Drugs in Oncology (ReDO)-clarithromycin as an anti-cancer agent. Ecancermedicalscience. 2015;9:513doi: 10.3332/ecancer.2015.513.
Van Nuffel, A. M., Sukhatme, V., Pantziarka, P., Meheus, L., Sukhatme, V. P., & Bouche, G. (2015). Repurposing Drugs in Oncology (ReDO)-clarithromycin as an anti-cancer agent. Ecancermedicalscience, 9513. https://doi.org/10.3332/ecancer.2015.513
Van Nuffel, An Mt, et al. "Repurposing Drugs in Oncology (ReDO)-clarithromycin as an anti-cancer agent." Ecancermedicalscience vol. 9 (2015): 513. doi: https://doi.org/10.3332/ecancer.2015.513
Van Nuffel AM, Sukhatme V, Pantziarka P, Meheus L, Sukhatme VP, Bouche G. Repurposing Drugs in Oncology (ReDO)-clarithromycin as an anti-cancer agent. Ecancermedicalscience. 2015 Feb 24;9:513. doi: 10.3332/ecancer.2015.513. eCollection 2015. PMID: 25729426; PMCID: PMC4341996.
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Ecancermedicalscience. 2015 Feb 24;9:513. doi: 10.3332/ecancer.2015.513. eCollection 2015.

Repurposing Drugs in Oncology (ReDO)-clarithromycin as an anti-cancer agent.

Ecancermedicalscience

An Mt Van Nuffel, Vidula Sukhatme, Pan Pantziarka, Lydie Meheus, Vikas P Sukhatme, Gauthier Bouche

Affiliations

  1. Anticancer Fund, Brussels, 1853 Strombeek-Bever, Belgium.
  2. GlobalCures, Inc, Newton, MA 02459, USA.
  3. Anticancer Fund, Brussels, 1853 Strombeek-Bever, Belgium ; The George Pantziarka TP53 Trust, London KT1 2JP, UK.
  4. GlobalCures, Inc, Newton, MA 02459, USA ; Beth Israel Deaconess Medical Centre and Harvard Medical School, Boston, MA 02215, USA.

PMID: 25729426 PMCID: PMC4341996 DOI: 10.3332/ecancer.2015.513

Abstract

Clarithromycin (CAM) is a well-known macrolide antibiotic available as a generic drug. CAM is traditionally used for many types of bacterial infections, treatment of Lyme disease and eradication of gastric infection with Helicobacter pylori. Extensive preclinical and clinical data demonstrate a potential role for CAM to treat various tumours in combination with conventional treatment. The mechanisms of action underlying the anti-tumour activity of CAM are multiple and include prolonged reduction of pro-inflammatory cytokines, autophagy inhibition, and anti-angiogenesis. Here, we present an overview of the current preclinical (in vitro and in vivo) and clinical evidence supporting the role of CAM in cancer. Overall these findings justify further research with CAM in many tumour types, with multiple myeloma, lymphoma, chronic myeloid leukaemia (CML), and lung cancer having the highest level of evidence. Finally, a series of proposals are being made to further investigate the use of CAM in clinical trials which offer the greatest prospect of clinical benefit to patients.

Keywords: ReDO project; anti-bacterial agents; antineoplastic agents; clarithromycin; drug repositioning; neoplasms

References

  1. Antimicrob Agents Chemother. 1994 Nov;38(11):2643-7 - PubMed
  2. Science. 2002 Dec 6;298(5600):1911-2 - PubMed
  3. Blood. 2008 Feb 1;111(3):1101-9 - PubMed
  4. Biochem Biophys Res Commun. 1995 May 25;210(3):781-6 - PubMed
  5. Br J Haematol. 2010 Jul;150(2):226-9 - PubMed
  6. Blood. 2012 May 24;119(21):4838-44; quiz 5057 - PubMed
  7. Nihon Rinsho. 2005 Nov;63 Suppl 11:308-11 - PubMed
  8. Cochrane Database Syst Rev. 2013 Nov 28;(11):CD009764 - PubMed
  9. J Antimicrob Chemother. 2002 May;49(5):745-55 - PubMed
  10. Clin Diagn Lab Immunol. 2000 Nov;7(6):925-31 - PubMed
  11. Am J Clin Oncol. 2003 Feb;26(1):92-4 - PubMed
  12. Br J Cancer. 2004 Mar 8;90(5):1047-52 - PubMed
  13. Int J Clin Pharmacol Ther. 2004 Jun;42(6):342-9 - PubMed
  14. Br J Haematol. 2008 Dec;143(5):654-60 - PubMed
  15. J Gastroenterol. 1998 Oct;33(5):613-7 - PubMed
  16. Mol Immunol. 2013 May;54(1):74-83 - PubMed
  17. Mediators Inflamm. 2004 Apr;13(2):111-7 - PubMed
  18. Proc Natl Acad Sci U S A. 1990 Oct;87(19):7678-82 - PubMed
  19. Blood. 2012 Nov 1;120(18):3858-60 - PubMed
  20. Cardiology. 2011;118(1):63-7 - PubMed
  21. Ann Allergy Asthma Immunol. 2001 Dec;87(6):501-5 - PubMed
  22. Am J Physiol Gastrointest Liver Physiol. 2001 Apr;280(4):G525-30 - PubMed
  23. Am J Physiol Lung Cell Mol Physiol. 2006 Jan;290(1):L75-85 - PubMed
  24. Pharmacol Res. 2012 Jul;66(1):7-18 - PubMed
  25. Cell Death Differ. 2009 Jul;16(7):1018-29 - PubMed
  26. Leuk Lymphoma. 2002 Sep;43(9):1777-82 - PubMed
  27. J Clin Oncol. 2013 Aug 10;31(23):2895-902 - PubMed
  28. Am J Hematol. 2010 Sep;85(9):664-9 - PubMed
  29. Cell Res. 2002 Mar;12(1):9-18 - PubMed
  30. Cardiology. 2008;111(4):280-7 - PubMed
  31. Cancer Res. 1993 Dec 1;53(23):5802-7 - PubMed
  32. Br J Haematol. 2003 Mar;120(5):790-2 - PubMed
  33. Clin Microbiol Rev. 2010 Jul;23(3):590-615 - PubMed
  34. Cell Death Differ. 2004 Jul;11 Suppl 1:S45-55 - PubMed
  35. Korean J Hematol. 2011 Sep;46(3):203-6 - PubMed
  36. Antimicrob Agents Chemother. 1992 May;36(5):1147-50 - PubMed
  37. Semin Oncol. 2003 Apr;30(2):270-4 - PubMed
  38. Mol Cancer Ther. 2011 Sep;10(9):1533-41 - PubMed
  39. BMJ. 2013 Mar 20;346:f1235 - PubMed
  40. Immunology. 2014 Jan;141(1):1-8 - PubMed
  41. Clin Exp Metastasis. 1999 Jun;17(4):361-7 - PubMed
  42. Eur J Gastroenterol Hepatol. 2001 Nov;13(11):1375-8 - PubMed
  43. Chemotherapy. 1997 Jul-Aug;43(4):288-96 - PubMed
  44. J Clin Oncol. 2011 Jul 1;29(19):2645-52 - PubMed
  45. Med Clin North Am. 2011 Jul;95(4):761-91, viii - PubMed
  46. Antimicrob Agents Chemother. 1999 Nov;43(11):2787-9 - PubMed
  47. J Clin Invest. 2014 Mar;124(3):1406-17 - PubMed
  48. Clin Cancer Res. 2011 Jul 1;17(13):4550-7 - PubMed
  49. Chemotherapy. 2000 Jan-Feb;46(1):49-61 - PubMed
  50. Lancet. 1997 Jul 12;350(9071):115-6 - PubMed
  51. J Allergy Clin Immunol. 1999 Jun;103(6):1031-5 - PubMed
  52. Respir Med. 2003 Jul;97(7):844-50 - PubMed
  53. J Natl Cancer Inst. 1974 Feb;52(2):413-27 - PubMed
  54. Chest. 2002 Dec;122(6):2137-45 - PubMed
  55. Clin Cancer Res. 2013 Jul 15;19(14):3966-76 - PubMed
  56. Eur J Cardiothorac Surg. 2010 Jul;38(1):21-6 - PubMed
  57. Haematologica. 2002 Jun;87(6):658-9 - PubMed
  58. Nat Rev Clin Oncol. 2014 Jul;11(7):413-31 - PubMed
  59. Leuk Lymphoma. 2012 Jul;53(7):1409-11 - PubMed
  60. Ann Pharmacother. 2004 Sep;38(9):1400-5 - PubMed
  61. Cancer. 2000 May 15;88(10):2210-9 - PubMed
  62. J Biol Chem. 1992 Nov 5;267(31):22506-11 - PubMed
  63. Leukemia. 1999 Mar;13(3):490-1 - PubMed
  64. Ann Oncol. 2001 Oct;12(10):1359-68 - PubMed
  65. Transfus Med Hemother. 2013 Oct;40(5):336-43 - PubMed
  66. Antimicrob Agents Chemother. 2001 Jan;45(1):44-7 - PubMed
  67. J Thromb Haemost. 2011 Feb;9(2):237-49 - PubMed
  68. Scand J Immunol. 1993 Jan;37(1):65-70 - PubMed
  69. Ann Hematol. 2013 Dec;92(12):1711-2 - PubMed
  70. Proc Natl Acad Sci U S A. 1998 Jul 21;95(15):8773-8 - PubMed
  71. Infect Immun. 1997 Aug;65(8):3218-24 - PubMed
  72. Anesth Analg. 2010 Jun 1;110(6):1630-5 - PubMed
  73. Res Exp Med (Berl). 1997;197(4):189-97 - PubMed
  74. Korean J Intern Med. 2013 May;28(3):377-9 - PubMed
  75. Am J Clin Pathol. 2010 Feb;133(2):305-13 - PubMed
  76. Lancet Oncol. 2010 Jan;11(1):29-37 - PubMed
  77. Leuk Lymphoma. 2007 Dec;48(12):2330-7 - PubMed
  78. Int J Cancer. 2001 Jun 1;92(5):634-40 - PubMed
  79. Leuk Lymphoma. 2014 Dec;55(12):2842-9 - PubMed
  80. Lancet. 2012 Apr 28;379(9826):1591-601 - PubMed
  81. Int J Antimicrob Agents. 2004 Sep;24(3):247-53 - PubMed
  82. Gut. 2003 Apr;52(4):507-9 - PubMed
  83. Antimicrob Agents Chemother. 2006 May;50(5):1738-44 - PubMed
  84. Blood. 2005 Dec 15;106(13):4050-3 - PubMed
  85. J Clin Oncol. 2001 Mar 15;19(6):1600-9 - PubMed
  86. J Clin Oncol. 2004 Sep 1;22(17):3491-7 - PubMed
  87. Antimicrob Agents Chemother. 1999 Jan;43(1):67-72 - PubMed
  88. J Chemother. 2013 Feb;25(1):49-55 - PubMed
  89. Drugs. 2001;61(4):443-98 - PubMed
  90. World J Surg Oncol. 2008 Mar 19;6:35 - PubMed
  91. Med Oncol. 2001;18(1):79-84 - PubMed
  92. J Clin Oncol. 2014 Apr 1;32(10):1020-30 - PubMed
  93. Am J Gastroenterol. 1998 Apr;93(4):584-90 - PubMed
  94. Scand J Gastroenterol. 2006 Mar;41(3):365-9 - PubMed
  95. Anticancer Res. 2004 Nov-Dec;24(6):3723-30 - PubMed
  96. Gastroenterology. 1999 Aug;117(2):514-5 - PubMed
  97. Ann Surg Oncol. 2013 Dec;20 Suppl 3:S650-60 - PubMed
  98. Biochem Biophys Res Commun. 2013 Jul 19;437(1):41-7 - PubMed
  99. Int Immunopharmacol. 2004 Sep;4(9):1201-7 - PubMed
  100. Clin Exp Immunol. 2007 Mar;147(3):540-6 - PubMed
  101. Antimicrob Agents Chemother. 1996 Jun;40(6):1366-70 - PubMed
  102. Int J Oncol. 2010 Oct;37(4):815-20 - PubMed
  103. J Natl Cancer Inst. 2014 May 29;106(6):dju124 - PubMed
  104. Am J Hematol. 2014 Aug;89(8):E116-20 - PubMed
  105. Int J Antimicrob Agents. 2002 Jan;19(1):53-9 - PubMed
  106. J Allergy Clin Immunol. 1996 Dec;98(6 Pt 2):S207-15 - PubMed
  107. Int J Oncol. 2012 Apr;40(4):1029-39 - PubMed
  108. Mol Biol Cell. 2008 Mar;19(3):797-806 - PubMed
  109. Blood. 1999 Jun 15;93(12):4441 - PubMed
  110. Oral Oncol. 2002 Jul;38(5):468-74 - PubMed
  111. Semin Oncol. 2005 Aug;32(4 Suppl 5):S24-30 - PubMed
  112. Gastrointest Endosc. 2001 Nov;54(5):643-5 - PubMed
  113. Proc Natl Acad Sci U S A. 2013 Oct 22;110(43):17450-5 - PubMed
  114. J Clin Oncol. 2001 Apr 1;19(7):2041-8 - PubMed
  115. Cancer Res. 2003 Aug 1;63(15):4342-6 - PubMed
  116. Chest. 2010 Sep;138(3):730-3 - PubMed
  117. PLoS One. 2014 Sep 19;9(9):e106914 - PubMed
  118. Cancer Discov. 2014 Jul;4(7):773-80 - PubMed
  119. Blood. 2013 Mar 14;121(11):1982-5 - PubMed
  120. Gut. 2004 Jan;53(1):34-7 - PubMed
  121. J Clin Oncol. 2001 Nov 15;19(22):4245-51 - PubMed
  122. Am J Respir Cell Mol Biol. 2000 Jan;22(1):51-60 - PubMed
  123. Br J Haematol. 2008 Nov;143(3):349-54 - PubMed
  124. Chemotherapy. 2001 Dec;47(6):444-51 - PubMed
  125. Cancer Lett. 2013 May 28;332(2):313-24 - PubMed
  126. Leuk Lymphoma. 2013 Jan;54(1):198-201 - PubMed
  127. Eur Surg Res. 2004 Jan-Feb;36(1):13-9 - PubMed
  128. Ann Surg Oncol. 2008 Jul;15(7):2042-52 - PubMed
  129. Ann Intern Med. 1999 Jul 20;131(2):88-95 - PubMed
  130. J Natl Cancer Inst. 2005 Sep 21;97(18):1345-53 - PubMed
  131. J Clin Gastroenterol. 2000 Sep;31(2):169-71 - PubMed
  132. Gut. 2001 Mar;48(3):297-303 - PubMed
  133. Int J Oncol. 2013 May;42(5):1541-50 - PubMed
  134. Cancer Lett. 1999 Dec 1;147(1-2):17-24 - PubMed
  135. Lancet. 2009 Oct 24;374(9699):1432-40 - PubMed
  136. Korean J Hematol. 2012 Dec;47(4):293-7 - PubMed
  137. Lab Invest. 2004 Apr;84(4):485-92 - PubMed
  138. Int Forum Allergy Rhinol. 2014 Jul;4(7):533-41 - PubMed
  139. Antimicrob Agents Chemother. 1999 Apr;43(4):907-11 - PubMed
  140. J Antimicrob Chemother. 2005 Sep;56(3):502-6 - PubMed
  141. Semin Oncol. 2003 Apr;30(2):265-9 - PubMed

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