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Rahal S, Gilabert M, Ries P, et al. Hepatocellular carcinoma in a noncirrhotic liver after long-term use of danazol for hereditary angioedema. Case Rep Oncol. 2014;7(3):825-7doi: 10.1159/000370106.
Rahal, S., Gilabert, M., Ries, P., Oziel-Taieb, S., Dermeche, S., & Raoul, J. L. (2014). Hepatocellular carcinoma in a noncirrhotic liver after long-term use of danazol for hereditary angioedema. Case reports in oncology, 7(3), 825-7. https://doi.org/10.1159/000370106
Rahal, Soraya, et al. "Hepatocellular carcinoma in a noncirrhotic liver after long-term use of danazol for hereditary angioedema." Case reports in oncology vol. 7,3 (2014): 825-7. doi: https://doi.org/10.1159/000370106
Rahal S, Gilabert M, Ries P, Oziel-Taieb S, Dermeche S, Raoul JL. Hepatocellular carcinoma in a noncirrhotic liver after long-term use of danazol for hereditary angioedema. Case Rep Oncol. 2014 Dec 09;7(3):825-7. doi: 10.1159/000370106. eCollection 2014. PMID: 25606032; PMCID: PMC4296231.
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Case Rep Oncol. 2014 Dec 09;7(3):825-7. doi: 10.1159/000370106. eCollection 2014.

Hepatocellular carcinoma in a noncirrhotic liver after long-term use of danazol for hereditary angioedema.

Case reports in oncology

Soraya Rahal, Marine Gilabert, Pauline Ries, Sandrine Oziel-Taieb, Slimane Dermeche, Jean-Luc Raoul

Affiliations

  1. Department of Medical Oncology, Paoli-Calmettes Institute, Marseille, France.

PMID: 25606032 PMCID: PMC4296231 DOI: 10.1159/000370106

Abstract

We report a 57-year-old male who was treated with high-dose danazol for hereditary angioedema for more than 30 years; he developed hepatocellular carcinoma in the absence of cirrhosis. Despite surgical resection, he had a recurrence and received sorafenib, but had a poor skin tolerance. Such tumors arising after danazol are infrequent, and this case is highly unique due to the minor lesions found on the liver.

Keywords: Danazol; Drug-induced cancer; Healthy liver; Hepatocellular carcinoma

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