Display options
Cite
Duval F, Moreno-Cuevas JE, González-Garza MT, et al. Protective mechanisms of medicinal plants targeting hepatic stellate cell activation and extracellular matrix deposition in liver fibrosis. Chin Med. 2014;9(1):27doi: 10.1186/s13020-014-0027-4.
Duval, F., Moreno-Cuevas, J. E., González-Garza, M. T., Rodríguez-Montalvo, C., & Cruz-Vega, D. E. (2014). Protective mechanisms of medicinal plants targeting hepatic stellate cell activation and extracellular matrix deposition in liver fibrosis. Chinese medicine, 9(1), 27. https://doi.org/10.1186/s13020-014-0027-4
Duval, Florent, et al. "Protective mechanisms of medicinal plants targeting hepatic stellate cell activation and extracellular matrix deposition in liver fibrosis." Chinese medicine vol. 9,1 (2014): 27. doi: https://doi.org/10.1186/s13020-014-0027-4
Duval F, Moreno-Cuevas JE, González-Garza MT, Rodríguez-Montalvo C, Cruz-Vega DE. Protective mechanisms of medicinal plants targeting hepatic stellate cell activation and extracellular matrix deposition in liver fibrosis. Chin Med. 2014 Dec 24;9(1):27. doi: 10.1186/s13020-014-0027-4. eCollection 2014. PMID: 25606051; PMCID: PMC4299307.
Copy Download .nbib Format: NLM
Share it on

Chin Med. 2014 Dec 24;9(1):27. doi: 10.1186/s13020-014-0027-4. eCollection 2014.

Protective mechanisms of medicinal plants targeting hepatic stellate cell activation and extracellular matrix deposition in liver fibrosis.

Chinese medicine

Florent Duval, Jorge E Moreno-Cuevas, María Teresa González-Garza, Carlos Rodríguez-Montalvo, Delia Elva Cruz-Vega

Affiliations

  1. Cell Therapy Department, School of Medicine, Tecnológico de Monterrey, Monterrey, NL CP 63710 Mexico.
  2. Centro de Enfermedades Hepáticas-Digestivas y Nutrición, HSJ, Monterrey, NL Mexico.

PMID: 25606051 PMCID: PMC4299307 DOI: 10.1186/s13020-014-0027-4

Abstract

During chronic liver injury, hepatic stellate cells (HSC) are activated and proliferate, which causes excessive extracellular matrix (ECM) deposition, leading to scar formation and fibrosis. Medicinal plants are gaining popularity as antifibrotic agents, and are often safe, cost-effective, and versatile. This review aims to describe the protective role and mechanisms of medicinal plants in the inhibition of HSC activation and ECM deposition during the pathogenesis of liver fibrosis. A systematic literature review on the anti-fibrotic mechanisms of hepatoprotective plants was performed in PubMed, which yielded articles about twelve relevant plants. Many of these plants act via disruption of the transforming growth factor beta 1 signaling pathway, possibly through reduction in oxidative stress. This reduction could explain the inhibition of HSC activation and reduction in ECM deposition. Medicinal plants could be a source of anti-liver fibrosis compounds.

References

  1. Hepatology. 1999 Mar;29(3):868-78 - PubMed
  2. Zhongguo Yao Li Xue Bao. 1997 Sep;18(5):478-80 - PubMed
  3. Zhongguo Xiu Fu Chong Jian Wai Ke Za Zhi. 1998 Nov;12(6):321-4 - PubMed
  4. Zhongguo Xiu Fu Chong Jian Wai Ke Za Zhi. 1998 Nov;12(6):325-8 - PubMed
  5. Proc Natl Acad Sci U S A. 1999 Oct 26;96(22):12719-24 - PubMed
  6. J Hepatol. 1999 Oct;31(4):703-11 - PubMed
  7. J Gastroenterol Hepatol. 1999 Nov;14(11):1093-9 - PubMed
  8. Biochem Biophys Res Commun. 2000 Jan 7;267(1):290-5 - PubMed
  9. Genes Dev. 2000 Jan 15;14(2):163-76 - PubMed
  10. Histochem Cell Biol. 2000 Jun;113(6):443-53 - PubMed
  11. Zhonghua Gan Zang Bing Za Zhi. 2000 Oct;8(5):299-301 - PubMed
  12. J Pharm Pharmacol. 2001 Feb;53(2):197-204 - PubMed
  13. Acta Pharmacol Sin. 2000 Aug;21(8):721-6 - PubMed
  14. Am J Gastroenterol. 2001 Aug;96(8):2432-7 - PubMed
  15. Semin Liver Dis. 2001 Aug;21(3):373-84 - PubMed
  16. Semin Liver Dis. 2001 Aug;21(3):397-416 - PubMed
  17. J Hepatol. 2001 Sep;35(3):392-8 - PubMed
  18. J Biol Chem. 2002 Mar 29;277(13):11069-76 - PubMed
  19. World J Gastroenterol. 2000 Jun;6(3):361-364 - PubMed
  20. World J Gastroenterol. 2001 Feb;7(1):115-9 - PubMed
  21. J Pharm Pharmacol. 2002 Jan;54(1):119-26 - PubMed
  22. Front Biosci. 2002 Apr 01;7:d808-26 - PubMed
  23. World J Gastroenterol. 2002 Jun;8(3):515-9 - PubMed
  24. Acta Pharmacol Sin. 2002 Aug;23(8):733-8 - PubMed
  25. World J Gastroenterol. 2002 Aug;8(4):679-85 - PubMed
  26. Zhonghua Yi Xue Za Zhi. 2002 Sep 25;82(18):1267-72 - PubMed
  27. MedGenMed. 2002 Jul 15;4(3):27 - PubMed
  28. Hepatology. 2003 Jan;37(1):4-12 - PubMed
  29. Zhongguo Xiu Fu Chong Jian Wai Ke Za Zhi. 2002 Nov;16(6):408-10 - PubMed
  30. Gastroenterology. 2003 Feb;124(2):445-58 - PubMed
  31. Planta Med. 2003 Jan;69(1):26-32 - PubMed
  32. J Hepatol. 2003 Mar;38(3):257-65 - PubMed
  33. J Hepatol. 2003;38 Suppl 1:S38-53 - PubMed
  34. Am J Physiol Gastrointest Liver Physiol. 2003 Jul;285(1):G20-30 - PubMed
  35. Chin Med Sci J. 1992 Sep;7(3):142-7 - PubMed
  36. J Clin Gastroenterol. 2003 Oct;37(4):336-9 - PubMed
  37. J Pharm Pharmacol. 2003 Nov;55(11):1561-8 - PubMed
  38. Hepatobiliary Pancreat Dis Int. 2004 Feb;3(1):102-5 - PubMed
  39. Zhongguo Zhong Xi Yi Jie He Za Zhi. 2004 Jan;24(1):17-20 - PubMed
  40. Zhong Yao Cai. 2003 Nov;26(11):795-8 - PubMed
  41. World J Gastroenterol. 2004 Apr 1;10(7):1037-42 - PubMed
  42. Gastroenterology. 2004 Apr;126(4):1122-33; discussion 949 - PubMed
  43. Biochem J. 2004 Nov 15;384(Pt 1):149-57 - PubMed
  44. Zhonghua Gan Zang Bing Za Zhi. 2004 Aug;12(8):471-4 - PubMed
  45. World J Gastroenterol. 2005 Jan 7;11(1):132-5 - PubMed
  46. J Clin Invest. 2005 Jan;115(1):29-32 - PubMed
  47. Int Immunopharmacol. 2005 Mar;5(3):555-69 - PubMed
  48. J Clin Invest. 2005 Feb;115(2):209-18 - PubMed
  49. World J Gastroenterol. 2005 Feb 28;11(8):1141-8 - PubMed
  50. Sichuan Da Xue Xue Bao Yi Xue Ban. 2005 Mar;36(2):221-4 - PubMed
  51. World J Gastroenterol. 2005 Apr 28;11(16):2444-9 - PubMed
  52. J Biomed Sci. 2005;12(1):185-95 - PubMed
  53. J Ethnopharmacol. 2005 Aug 22;100(1-2):180-6 - PubMed
  54. Zhong Xi Yi Jie He Xue Bao. 2005 Jul;3(4):286-9 - PubMed
  55. Methods Mol Med. 2005;117:69-80 - PubMed
  56. World J Gastroenterol. 2005 Sep 21;11(35):5444-9 - PubMed
  57. Am J Physiol Gastrointest Liver Physiol. 2006 May;290(5):G883-93 - PubMed
  58. Zhonghua Gan Zang Bing Za Zhi. 2005 Nov;13(11):828-31 - PubMed
  59. J Ethnopharmacol. 2006 Apr 21;105(1-2):215-22 - PubMed
  60. Liver Int. 2005 Dec;25(6):1224-32 - PubMed
  61. Zhonghua Gan Zang Bing Za Zhi. 2005 Dec;13(12):903-7 - PubMed
  62. Am J Chin Med. 2006;34(1):99-114 - PubMed
  63. Zhong Yao Cai. 2005 Sep;28(9):850-4 - PubMed
  64. FASEB J. 2006 Mar;20(3):444-54 - PubMed
  65. World J Gastroenterol. 2006 Apr 14;12(14):2195-200 - PubMed
  66. Zhonghua Gan Zang Bing Za Zhi. 2006 May;14(5):337-40 - PubMed
  67. World J Gastroenterol. 2006 Jun 28;12(24):3924-8 - PubMed
  68. J Pharm Pharmacol. 2006 Jul;58(7):933-9 - PubMed
  69. Zhongguo Zhong Xi Yi Jie He Za Zhi. 2006 May;26(5):439-42 - PubMed
  70. J Hepatol. 2006 Oct;45(4):539-46 - PubMed
  71. J Gene Med. 2006 Nov;8(11):1291-9 - PubMed
  72. Chin J Integr Med. 2006 Sep;12(3):207-11 - PubMed
  73. Arch Pharm Res. 2006 Sep;29(9):762-7 - PubMed
  74. Liver Int. 2006 Dec;26(10):1283-90 - PubMed
  75. Zhongguo Zhong Xi Yi Jie He Za Zhi. 2006 Oct;26(10):936-8 - PubMed
  76. Clin Sci (Lond). 2007 Mar;112(5):265-80 - PubMed
  77. Liver Int. 2007 Apr;27(3):373-83 - PubMed
  78. J Immunol. 2007 Apr 15;178(8):5288-95 - PubMed
  79. Chin Med J (Engl). 2007 May 5;120(9):794-801 - PubMed
  80. Biochem Cell Biol. 2007 Apr;85(2):189-95 - PubMed
  81. Zhongguo Zhong Xi Yi Jie He Za Zhi. 2007 May;27(5):439-43 - PubMed
  82. J Pharm Biomed Anal. 2007 Nov 30;45(4):635-41 - PubMed
  83. Phytother Res. 2008 Jan;22(1):69-76 - PubMed
  84. Zhonghua Gan Zang Bing Za Zhi. 2007 Oct;15(10):753-7 - PubMed
  85. Br J Pharmacol. 2008 Feb;153(3):557-67 - PubMed
  86. Clin Exp Pharmacol Physiol. 2008 Mar;35(3):303-9 - PubMed
  87. Mol Pharmacol. 2008 Feb;73(2):399-409 - PubMed
  88. Physiol Rev. 2008 Jan;88(1):125-72 - PubMed
  89. J Ethnopharmacol. 2008 Mar 28;116(3):447-53 - PubMed
  90. J Pharm Pharmacol. 2008 Jan;60(1):91-7 - PubMed
  91. Zhonghua Gan Zang Bing Za Zhi. 2008 Mar;16(3):193-7 - PubMed
  92. Gastroenterology. 2008 May;134(6):1655-69 - PubMed
  93. J Hepatol. 2008 Nov;49(5):758-67 - PubMed
  94. Zhongguo Zhong Yao Za Zhi. 2008 Apr;33(8):915-9 - PubMed
  95. Fundam Clin Pharmacol. 2008 Aug;22(4):417-27 - PubMed
  96. Life Sci. 2008 Oct 10;83(15-16):531-9 - PubMed
  97. Clin Liver Dis. 2008 Nov;12(4):733-46, vii - PubMed
  98. Clin Liver Dis. 2008 Nov;12(4):939-62, xi - PubMed
  99. Phytother Res. 2009 Jul;23(7):927-32 - PubMed
  100. Liver Int. 2009 Jul;29(6):886-97 - PubMed
  101. Endocrinology. 2009 Jul;150(7):3011-20 - PubMed
  102. J Hepatol. 2009 May;50(5):1053-5 - PubMed
  103. Zhongguo Zhong Xi Yi Jie He Za Zhi. 2009 Jan;29(1):60-4 - PubMed
  104. Curr Opin Gastroenterol. 2009 May;25(3):223-9 - PubMed
  105. J Hepatol. 2009 Jun;50(6):1102-11 - PubMed
  106. J Nat Med. 2009 Oct;63(4):415-20 - PubMed
  107. Br J Pharmacol. 2009 Aug;157(8):1354-67 - PubMed
  108. Biochem Biophys Res Commun. 2009 Oct 9;388(1):31-4 - PubMed
  109. Biol Pharm Bull. 2009 Sep;32(9):1533-7 - PubMed
  110. Lab Invest. 2009 Nov;89(11):1275-90 - PubMed
  111. Eur J Pharmacol. 2009 Nov 25;623(1-3):119-24 - PubMed
  112. World J Gastroenterol. 2009 Oct 7;15(37):4720-5 - PubMed
  113. Toxicol Appl Pharmacol. 2010 Jan 15;242(2):155-64 - PubMed
  114. J Clin Pharmacol. 2010 Apr;50(4):434-49 - PubMed
  115. Lab Invest. 2009 Dec;89(12):1397-409 - PubMed
  116. Lab Invest. 2010 Jan;90(1):104-15 - PubMed
  117. Clin Nutr. 2010 Jun;29(3):399-405 - PubMed
  118. Am J Chin Med. 2010;38(1):99-111 - PubMed
  119. Eur J Pharmacol. 2010 May 25;634(1-3):162-9 - PubMed
  120. Zhongguo Zhong Xi Yi Jie He Za Zhi. 2009 Nov;29(11):1012-7 - PubMed
  121. Zhongguo Zhong Yao Za Zhi. 2010 Jan;35(1):71-5 - PubMed
  122. J Sci Food Agric. 2010 Feb;90(3):450-5 - PubMed
  123. Eur J Pharmacol. 2010 Jul 25;638(1-3):134-41 - PubMed
  124. Apoptosis. 2010 Aug;15(8):904-14 - PubMed
  125. J Ethnopharmacol. 2010 Nov 11;132(2):384-92 - PubMed
  126. Semin Liver Dis. 2010 Aug;30(3):245-57 - PubMed
  127. Pharm Biol. 2011 Jan;49(1):38-45 - PubMed
  128. Eur J Pharmacol. 2011 Jan 10;650(1):390-5 - PubMed
  129. Hepatology. 2010 Nov;52(5):1652-61 - PubMed
  130. Toxicol Mech Methods. 2011 Jan;21(1):48-52 - PubMed
  131. Aliment Pharmacol Ther. 2011 Jan;33(1):127-37 - PubMed
  132. Zhongguo Ying Yong Sheng Li Xue Za Zhi. 2007 Nov;23(4):482-6 - PubMed
  133. Zhongguo Ying Yong Sheng Li Xue Za Zhi. 2003 Feb;19(1):78-81 - PubMed
  134. Am J Physiol Gastrointest Liver Physiol. 2011 May;300(5):G709-15 - PubMed
  135. Toxicol Appl Pharmacol. 2011 Apr 15;252(2):165-75 - PubMed
  136. Planta Med. 2011 Sep;77(13):1495-503 - PubMed
  137. Hepatol Int. 2011 Sep;5(3):857-63 - PubMed
  138. Best Pract Res Clin Gastroenterol. 2011 Apr;25(2):195-206 - PubMed
  139. Exp Mol Med. 2011 Jun 30;43(6):341-9 - PubMed
  140. Environ Toxicol Pharmacol. 2009 Jul;28(1):1-10 - PubMed
  141. Chem Biol Interact. 2011 Sep 30;193(3):225-31 - PubMed
  142. Evid Based Complement Alternat Med. 2012;2012:960128 - PubMed
  143. Drug Metab Dispos. 2011 Dec;39(12):2182-90 - PubMed
  144. J Med Food. 2011 Oct;14(10):1135-43 - PubMed
  145. Chem Biol Interact. 2011 Nov 15;194(2-3):106-12 - PubMed
  146. J Physiol Biochem. 2012 Mar;68(1):29-35 - PubMed
  147. Hepatol Res. 2011 Nov;41(11):1094-109 - PubMed
  148. J Sci Food Agric. 2012 May;92(7):1441-7 - PubMed
  149. Med Sci Monit. 2012 Jan;18(1):BR24-32 - PubMed
  150. Parasit Vectors. 2012 Jan 11;5:9 - PubMed
  151. J Hepatol. 2012 May;56(5):1171-80 - PubMed
  152. Zhongguo Ying Yong Sheng Li Xue Za Zhi. 2011 Nov;27(4):402-6 - PubMed
  153. Br J Pharmacol. 2012 Aug;166(8):2212-27 - PubMed
  154. Food Chem Toxicol. 2012 May;50(5):1568-75 - PubMed
  155. Zhong Xi Yi Jie He Xue Bao. 2012 Apr;10(4):454-61 - PubMed
  156. Basic Clin Pharmacol Toxicol. 2012 Nov;111(5):339-47 - PubMed
  157. Food Chem Toxicol. 2012 Sep;50(9):3343-51 - PubMed
  158. Curr Med Chem. 2012;19(28):4850-60 - PubMed
  159. Int J Mol Med. 2012 Sep;30(3):473-9 - PubMed
  160. Br J Nutr. 2013 Feb 14;109(3):394-401 - PubMed
  161. J Viral Hepat. 2012 Aug;19(8):537-46 - PubMed
  162. JAMA. 2012 Jul 18;308(3):274-82 - PubMed
  163. PLoS One. 2012;7(8):e42507 - PubMed
  164. J Appl Toxicol. 2013 Sep;33(9):970-9 - PubMed
  165. Phytother Res. 2013 Jul;27(7):1023-8 - PubMed
  166. Mol Med Rep. 2012 Dec;6(6):1231-8 - PubMed
  167. BMC Complement Altern Med. 2012 Sep 16;12:156 - PubMed
  168. Environ Toxicol Pharmacol. 2012 Nov;34(3):1004-13 - PubMed
  169. Lab Invest. 2012 Dec;92(12):1738-48 - PubMed
  170. J Ethnopharmacol. 2012 Dec 18;144(3):592-8 - PubMed
  171. Zhong Xi Yi Jie He Xue Bao. 2012 Oct;10(10):1155-61 - PubMed
  172. Eur Rev Med Pharmacol Sci. 2012 Oct;16(11):1484-98 - PubMed
  173. Toxicology. 2013 Jan 7;303:107-14 - PubMed
  174. Evid Based Complement Alternat Med. 2012;2012:160726 - PubMed
  175. Clin Gastroenterol Hepatol. 2013 Mar;11(3):224-31.e1-5 - PubMed
  176. Asian Pac J Cancer Prev. 2012;13(11):5405-8 - PubMed
  177. Zhonghua Gan Zang Bing Za Zhi. 2012 Dec;20(12):902-7 - PubMed
  178. J Ethnopharmacol. 2013 Jul 9;148(2):671-81 - PubMed
  179. J Ginseng Res. 2013 Mar;37(1):45-53 - PubMed
  180. J Med Food. 2013 Jun;16(6):518-28 - PubMed
  181. J Gastroenterol Hepatol. 2013 Dec;28(12):1877-84 - PubMed
  182. BMC Complement Altern Med. 2013 Jul 05;13:160 - PubMed
  183. Parasit Vectors. 2013 Jul 05;6:199 - PubMed
  184. World J Gastroenterol. 2013 Jun 28;19(24):3781-91 - PubMed
  185. Toxicol Lett. 2013 Sep 12;222(1):72-82 - PubMed
  186. Eur J Gastroenterol Hepatol. 2014 Feb;26(2):164-73 - PubMed
  187. Zhongguo Zhong Yao Za Zhi. 2013 Apr;38(8):1206-10 - PubMed
  188. Phytomedicine. 2013 Nov 15;20(14):1330-5 - PubMed
  189. Exp Biol Med (Maywood). 2013 Nov 1;238(11):1284-96 - PubMed
  190. Eur J Pharmacol. 2013 Dec 5;721(1-3):133-40 - PubMed
  191. J Clin Chem Clin Biochem. 1989 Sep;27(9):555-65 - PubMed
  192. Gastroenterology Res. 2008 Dec;1(1):20-28 - PubMed
  193. Hepatology. 1995 Jul;22(1):304-15 - PubMed
  194. Zhongguo Yi Xue Ke Xue Yuan Xue Bao. 1993 Oct;15(5):364-8 - PubMed
  195. Zhongguo Yi Xue Ke Xue Yuan Xue Bao. 1993 Jun;15(3):201-5 - PubMed
  196. Hepatology. 1996 May;23(5):1189-99 - PubMed
  197. Zhongguo Zhong Xi Yi Jie He Za Zhi. 1995 Oct;15(10):593-5 - PubMed
  198. Gastroenterology. 1996 Sep;111(3):745-54 - PubMed
  199. Hepatology. 1997 Sep;26(3):643-9 - PubMed
  200. Cytokine Growth Factor Rev. 1997 Sep;8(3):171-9 - PubMed
  201. J Hepatol. 1998 Nov;29(5):760-71 - PubMed
  202. J Hepatol. 1999 Jan;30(1):48-60 - PubMed

Publication Types