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Brown CA, Nile TA, Mahon MF, et al. Iron catalysed Negishi cross-coupling using simple ethyl-monophosphines. Dalton Trans. 2015;44(27):12189-95doi: 10.1039/c5dt00112a.
Brown, C. A., Nile, T. A., Mahon, M. F., & Webster, R. L. (2015). Iron catalysed Negishi cross-coupling using simple ethyl-monophosphines. Dalton transactions (Cambridge, England : 2003), 44(27), 12189-95. https://doi.org/10.1039/c5dt00112a
Brown, Caleb A, et al. "Iron catalysed Negishi cross-coupling using simple ethyl-monophosphines." Dalton transactions (Cambridge, England : 2003) vol. 44,27 (2015): 12189-95. doi: https://doi.org/10.1039/c5dt00112a
Brown CA, Nile TA, Mahon MF, Webster RL. Iron catalysed Negishi cross-coupling using simple ethyl-monophosphines. Dalton Trans. 2015 Jul 21;44(27):12189-95. doi: 10.1039/c5dt00112a. Epub 2015 Mar 02. PMID: 25730705.
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Dalton Trans. 2015 Jul 21;44(27):12189-95. doi: 10.1039/c5dt00112a. Epub 2015 Mar 02.

Iron catalysed Negishi cross-coupling using simple ethyl-monophosphines.

Dalton transactions (Cambridge, England : 2003)

Caleb A Brown, Terence A Nile, Mary F Mahon, Ruth L Webster

Affiliations

  1. Department of Chemistry, University of Bath, Claverton Down, Bath, BA2 7AY, UK. [email protected].

PMID: 25730705 DOI: 10.1039/c5dt00112a

Abstract

Monophosphines prepared by iron catalysed hydrophosphination have been used as pro-ligands in iron catalysed Negishi cross-coupling of alkyl bromides and diphenyl zinc reagents. The cross-coupling has been investigated with monophosphines with varying electronic properties and we find the simplest, unsubstituted phosphine to offer the optimum reaction conditions (both in terms of yield of diarylmethane product and cost-effectiveness of the phosphine). In situ catalyst generation from monophosphine and FeCl2 was used in catalysis; however, preparation of a discrete homonuclear iron complex was also achieved and this four-coordinate iron-phosphine complex was isolated and used in catalysis.

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