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Rutkowski TW, Maciejewski B, Kołosza Z, et al. The effect of tumor volume on radiotherapy outcome and correlation with other prognostic factors in patients with T2 supraglottic cancer. Contemp Oncol (Pozn). 2014;18(6):429-35doi: 10.5114/wo.2014.44542.
Rutkowski, T. W., Maciejewski, B., Kołosza, Z., Wygoda, A., Składowski, K., Hejduk, B., & Rutkowski, R. (2014). The effect of tumor volume on radiotherapy outcome and correlation with other prognostic factors in patients with T2 supraglottic cancer. Contemporary oncology (Poznan, Poland), 18(6), 429-35. https://doi.org/10.5114/wo.2014.44542
Rutkowski, Tomasz W, et al. "The effect of tumor volume on radiotherapy outcome and correlation with other prognostic factors in patients with T2 supraglottic cancer." Contemporary oncology (Poznan, Poland) vol. 18,6 (2014): 429-35. doi: https://doi.org/10.5114/wo.2014.44542
Rutkowski TW, Maciejewski B, Kołosza Z, Wygoda A, Składowski K, Hejduk B, Rutkowski R. The effect of tumor volume on radiotherapy outcome and correlation with other prognostic factors in patients with T2 supraglottic cancer. Contemp Oncol (Pozn). 2014;18(6):429-35. doi: 10.5114/wo.2014.44542. Epub 2014 Dec 31. PMID: 25784843; PMCID: PMC4355652.
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Contemp Oncol (Pozn). 2014;18(6):429-35. doi: 10.5114/wo.2014.44542. Epub 2014 Dec 31.

The effect of tumor volume on radiotherapy outcome and correlation with other prognostic factors in patients with T2 supraglottic cancer.

Contemporary oncology (Poznan, Poland)

Tomasz W Rutkowski, Bogusław Maciejewski, Zofia Kołosza, Andrzej Wygoda, Krzysztof Składowski, Beata Hejduk, Roman Rutkowski

Affiliations

  1. Department of Radiotherapy and Chemotherapy, Maria Sklodowska-Curie Memorial Cancer Centre and Institute of Oncology, Gliwice Branch, Poland.
  2. Department of Radiotherapy, Maria Sklodowska-Curie Memorial Cancer Centre and Institute of Oncology, Gliwice Branch, Poland.
  3. Department of Cancer Epidemiology, Maria Sklodowska-Curie Memorial Cancer Centre and Institute of Oncology, Gliwice Branch, Poland.
  4. Department of Medical Diagnostic, Maria Sklodowska-Curie Memorial Cancer Centre and Institute of Oncology, Gliwice Branch, Poland.

PMID: 25784843 PMCID: PMC4355652 DOI: 10.5114/wo.2014.44542

Abstract

The retrospective chart review of 110 patients with T2 supraglottic cancer who underwent radiotherapy was performed to correlate tumor volume with other prognostic factors and to analyze its impact on treatment results. Patients with involved nodes, poor histopathological tumor differentiation, or hemoglobin concentration ≤ 14.3 g/dl had significantly larger tumors. Patients with large tumors had significantly lower 5-year local control rate, overall survival rate and presented significantly higher risk of nodal involvement and the ratio of poor histopathological differentiation of the tumor. Tumor volume significantly impacts radiotherapy outcome and should be considered to optimize treatment strategy for patients with T2 supraglottic cancer.

Keywords: T2 laryngeal cancer; head and neck cancer; radiotherapy; tumor volume

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