Display options
Cite
Wu M, Cheng T, Ji M, et al. Ru-Catalyzed asymmetric transfer hydrogenation of α-trifluoromethylimines. J Org Chem. 2015;80(7):3708-13doi: 10.1021/acs.joc.5b00177.
Wu, M., Cheng, T., Ji, M., & Liu, G. (2015). Ru-Catalyzed asymmetric transfer hydrogenation of α-trifluoromethylimines. The Journal of organic chemistry, 80(7), 3708-13. https://doi.org/10.1021/acs.joc.5b00177
Wu, Meng, et al. "Ru-Catalyzed asymmetric transfer hydrogenation of α-trifluoromethylimines." The Journal of organic chemistry vol. 80,7 (2015): 3708-13. doi: https://doi.org/10.1021/acs.joc.5b00177
Wu M, Cheng T, Ji M, Liu G. Ru-Catalyzed asymmetric transfer hydrogenation of α-trifluoromethylimines. J Org Chem. 2015 Apr 03;80(7):3708-13. doi: 10.1021/acs.joc.5b00177. Epub 2015 Mar 19. PMID: 25759278.
Copy Download .nbib Format: NLM
Share it on

J Org Chem. 2015 Apr 03;80(7):3708-13. doi: 10.1021/acs.joc.5b00177. Epub 2015 Mar 19.

Ru-Catalyzed asymmetric transfer hydrogenation of α-trifluoromethylimines.

The Journal of organic chemistry

Meng Wu, Tanyu Cheng, Min Ji, Guohua Liu

Affiliations

  1. Key Laboratory of Resource Chemistry of Ministry of Education, Shanghai Key Laboratory of Rare Earth Functional Materials, Shanghai Normal University, Shanghai 200234, P. R. China.

PMID: 25759278 DOI: 10.1021/acs.joc.5b00177

Abstract

Enantioselective transformation of strong electron-withdrawing acyclic α-trifluoromethylimines to α-trifluoromethylamines through a ruthenium-catalyzed asymmetric transfer hydrogenation has been developed. The method described here is a facile catalytic process with sodium formate as a hydrogen resource and water-dimethylformamide as a cosolvent. The benefit of this enantioselective transformation affords a series of chiral α-trifluoromethylamines with high yields and excellent enantioselectivities (93-99% ee) under mild reaction conditions.

Publication Types