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Xi EP, Zhu J, Zhu SB, et al. Feasibility study on the application of fenestrated stent grafts in canine aortic arches. Int J Clin Exp Med. 2015;8(1):744-50
Xi, E. P., Zhu, J., Zhu, S. B., Zhang, Y., & Xu, G. H. (2015). Feasibility study on the application of fenestrated stent grafts in canine aortic arches. International journal of clinical and experimental medicine, 8(1), 744-50.
Xi, Er-Ping, et al. "Feasibility study on the application of fenestrated stent grafts in canine aortic arches." International journal of clinical and experimental medicine vol. 8,1 (2015): 744-50.
Xi EP, Zhu J, Zhu SB, Zhang Y, Xu GH. Feasibility study on the application of fenestrated stent grafts in canine aortic arches. Int J Clin Exp Med. 2015 Jan 15;8(1):744-50. eCollection 2015. PMID: 25785052; PMCID: PMC4358507.
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Int J Clin Exp Med. 2015 Jan 15;8(1):744-50. eCollection 2015.

Feasibility study on the application of fenestrated stent grafts in canine aortic arches.

International journal of clinical and experimental medicine

Er-Ping Xi, Jian Zhu, Shui-Bo Zhu, Yu Zhang, Gui-Hua Xu

Affiliations

  1. Department of Thoracic Cardiovascular Surgery, Wuhan General Hospital of Guangzhou Command Wuhan 430070, Hubei Province, People's Republic of China.

PMID: 25785052 PMCID: PMC4358507

Abstract

OBJECTIVE: To validate the feasibility and effectiveness of applying fenestrated stent grafts in canine aortic arches.

METHODS: According to the anatomic characteristics of the aortic arches from four adult beagle dogs, a straight-type aortic coated vascular stent system from Lifetech Scientific (Shenzhen) Co., Ltd. was released in vitro, after which a square window was burnt out at the back tendon of the coated vascular stent with an electrocautery pen, and the fenestrated stent grafts were then returned in the catheter and delivery sheath, following the original release path. Endovascular aortic repair (EVAR) was then performed in the canine aorta. Immediately after surgery, digital subtraction angiography (DSA) and computed tomography (CT) angiography were conducted. On day 3, the dressing was changed, and on day 7, the stitches were removed and CT angiography was reviewed. Animal autopsies were performed 2 weeks after surgery.

RESULTS: DSA and CT angiography were conducted in 4 beagles immediately after the experiments. The CT angiography reviewed on day 7 after surgery and the animal autopsy performed two weeks after surgery both revealed that the fenestrated stent grafts were anchored in the canine aortic arch, the openings were aligned against the branch vessels above the aortic arch, and in each branch vessel, the blood flow was smooth, without any obvious internal leakage phenomena.

CONCLUSION: An ordinary straight-type coated vascular stent, fenestrated in vitro, followed by the performance of EVAR in the canine aortic arch for in vivo stent implantation, was technically feasible. When a branch coated vascular stent cannot meet the individual needs of the wound, this technology may provide a valuable strategy for clinical thoracic aortic trauma emergencies.

Keywords: Endovascular repair; aortic dissection; fenestration; stent

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