Display options
Cite
Huang HD, Yang CM, Shu HF, et al. Genetic predisposition of stroke: understanding the evolving landscape through meta-analysis. Int J Clin Exp Med. 2015;8(1):1315-23
Huang, H. D., Yang, C. M., Shu, H. F., Kuang, Y. Q., Yang, T., He, W. Q., Zhao, K., Xia, X., Cheng, J. M., Ma, Y., Gu, J. W., Barak, M., & Zadok, Y. (2015). Genetic predisposition of stroke: understanding the evolving landscape through meta-analysis. International journal of clinical and experimental medicine, 8(1), 1315-23.
Huang, Hai-Dong, et al. "Genetic predisposition of stroke: understanding the evolving landscape through meta-analysis." International journal of clinical and experimental medicine vol. 8,1 (2015): 1315-23.
Huang HD, Yang CM, Shu HF, Kuang YQ, Yang T, He WQ, Zhao K, Xia X, Cheng JM, Ma Y, Gu JW, Barak M, Zadok Y. Genetic predisposition of stroke: understanding the evolving landscape through meta-analysis. Int J Clin Exp Med. 2015 Jan 15;8(1):1315-23. eCollection 2015. PMID: 25785132; PMCID: PMC4358587.
Copy Download .nbib Format: NLM
Share it on

Int J Clin Exp Med. 2015 Jan 15;8(1):1315-23. eCollection 2015.

Genetic predisposition of stroke: understanding the evolving landscape through meta-analysis.

International journal of clinical and experimental medicine

Hai-Dong Huang, Chun-Min Yang, Hai-Feng Shu, Yong-Qin Kuang, Tao Yang, Wei-Qi He, Kai Zhao, Xun Xia, Jing-Min Cheng, Yuan Ma, Jian-Wen Gu, Barak, Zadok

Affiliations

  1. Department of Neurosurgery, General Hospital of The People's Liberation Army Chengdu Military Region Sichuan 610083, China.
  2. Department of Medical Imaging, General Hospital of The People's Liberation Army Chengdu Military Region Sichuan 610083, China.

PMID: 25785132 PMCID: PMC4358587

Abstract

Stroke, either ischemic or hemorrhagic, is the leading cause of death and morbidity worldwide. Identifying the risk factors is a prerequisite step for stroke prevention and treatment. It is believed that a major portion of the currently unidentified risk factors is of genetic origin. Consistent with this idea, numerous potential risk alleles for stroke have been reported, however, the genetic evidence so far is not conclusive. The major goal of this review is to update the current knowledge about the genetic predisposition to the common multifactorial stroke, and to provide a bird's-eye view of this fast moving field. We selectively review and meta-analyze the related English literatures in public domain (PubMed) from 2000 onward, including the original reports and meta-analyses, to evaluate the genetic risk factors of common multifactorial stroke. The results indicated that we reviewed and meta-analyzed original reports and existing meta-analyses that studied the genetic predisposition to the common multifactorial stroke. Some original reports and meta-analyses were specific for ischemic stroke and others were for hemorrhagic stroke only. We also evaluated the major evolving issues in this field and discussed the future directions. In conclusion, strong evidences suggest that genetic risk factors contribute to common multifactorial stroke, and many genetic risk genes have been implicated in the literatures. However, not a single risk allele has been conclusively approved.

Keywords: Genetic predisposition/risk; hemorrhagic stroke; ischemic stroke

References

  1. Can J Cardiol. 2013 Jul;29(7 Suppl):S4-S13 - PubMed
  2. Stroke. 2008 Jan;39(1):16-23 - PubMed
  3. J Neuroinflammation. 2012 Oct 10;9:235 - PubMed
  4. Int J Clin Exp Med. 2009 Jul 08;2(2):193-202 - PubMed
  5. Gene. 2013 Oct 10;528(2):84-92 - PubMed
  6. PLoS One. 2008;3(11):e3691 - PubMed
  7. Int J Neurosci. 2014 Sep;124(9):642-51 - PubMed
  8. Acta Clin Croat. 2010 Dec;49(4):429-39 - PubMed
  9. Neurology. 2013 Jan 15;80(3 Suppl 2):S5-12 - PubMed
  10. J Stroke Cerebrovasc Dis. 2014 Jan;23(1):194-5 - PubMed
  11. Stroke. 2006 Nov;37(11):2667-71 - PubMed
  12. Int J Clin Exp Med. 2014 Mar 15;7(3):751-7 - PubMed
  13. Inflammation. 2014 Apr;37(2):599-603 - PubMed
  14. Cerebrovasc Dis. 2006;21(4):266-70 - PubMed
  15. Cardiol Rev. 2013 Mar-Apr;21(2):77-93 - PubMed
  16. Arterioscler Thromb Vasc Biol. 2006 Aug;26(8):1920-5 - PubMed
  17. Cerebrovasc Dis. 2004;17(2-3):197-203 - PubMed
  18. Neurol India. 2010 Mar-Apr;58(2):185-90 - PubMed
  19. Lancet Neurol. 2007 May;6(5):414-20 - PubMed
  20. Biomed Pap Med Fac Univ Palacky Olomouc Czech Repub. 2013 Jun;157(2):168-71 - PubMed
  21. Bull World Health Organ. 1976;54(5):541-53 - PubMed
  22. Stroke. 2003 Jul;34(7):1617-22 - PubMed
  23. Neurol Res. 2005 Jan;27(1):73-6 - PubMed
  24. Stroke. 2002 Mar;33(3):769-74 - PubMed
  25. J Neurol Sci. 2011 May 15;304(1-2):67-70 - PubMed
  26. Brain Res Bull. 2006 Dec 11;71(1-3):45-50 - PubMed
  27. Am J Hypertens. 1997 Dec;10(12 Pt 1):1391-5 - PubMed
  28. Gene. 2014 Feb 10;535(2):359-64 - PubMed
  29. Stroke. 2002 May;33(5):1190-5 - PubMed
  30. Blood. 2001 May 15;97(10):2979-82 - PubMed
  31. J Clin Neurosci. 2014 Feb;21(2):198-202 - PubMed
  32. Nat Genet. 1997 Aug;16(4):364-7 - PubMed
  33. Am J Hematol. 2001 Jul;67(3):183-8 - PubMed
  34. Ther Adv Cardiovasc Dis. 2008 Aug;2(4):287-303 - PubMed
  35. Int J Clin Exp Med. 2014 Apr 15;7(4):1182-7 - PubMed
  36. Am J Med Sci. 2013 Mar;345(3):227-33 - PubMed
  37. J Neurol Sci. 2014 Jan 15;336(1-2):93-8 - PubMed
  38. Eur J Neurol. 2007 Oct;14(10):1098-101 - PubMed
  39. Neurology. 2008 Apr 15;70(16):1322-8 - PubMed
  40. Stroke. 2006 Feb;37(2):364-70 - PubMed
  41. Cerebrovasc Dis. 2005;19(3):165-70 - PubMed
  42. ARYA Atheroscler. 2012 Winter;7(4):142-5 - PubMed
  43. Pharmacogenet Genomics. 2011 Mar;21(3):136-41 - PubMed
  44. J Korean Med Sci. 2002 Apr;17(2):249-53 - PubMed
  45. BMC Neurol. 2010 Jun 10;10:41 - PubMed
  46. J Neurosci Res. 2012 Sep;90(9):1782-7 - PubMed
  47. Int J Clin Exp Med. 2014 Feb 15;7(2):400-4 - PubMed
  48. Thromb Res. 2012 Mar;129(3):330-5 - PubMed
  49. Curr Neurol Neurosci Rep. 2010 Jan;10(1):14-20 - PubMed
  50. Nat Genet. 1993 Mar;3(3):256-9 - PubMed
  51. Cerebrovasc Dis. 2007;24(5):418-25 - PubMed
  52. Stroke. 2006 Nov;37(11):2843-5 - PubMed
  53. Int J Clin Exp Med. 2014 Jan 15;7(1):57-66 - PubMed
  54. Stroke. 2007 Jan;38(1):34-40 - PubMed
  55. Int J Clin Exp Med. 2014 Aug 15;7(8):2009-16 - PubMed
  56. Cerebrovasc Dis. 2010;29(6):528-37 - PubMed
  57. Curr Cardiovasc Risk Rep. 2011 Dec 1;5(6):533-541 - PubMed
  58. Stroke. 2000 Jun;31(6):1299-306 - PubMed
  59. J Neurol Sci. 2002 Mar 30;195(2):117-22 - PubMed
  60. Int J Clin Exp Med. 2014 Aug 15;7(8):1979-89 - PubMed

Publication Types