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Raimondi F, Migliaro F, Di Pietro E, et al. Nitric oxide-sensitive pulmonary hypertension in congenital rubella syndrome. Case Rep Crit Care. 2015;2015:198570doi: 10.1155/2015/198570.
Raimondi, F., Migliaro, F., Di Pietro, E., Borgia, F., Rapacciuolo, A., & Capasso, L. (2015). Nitric oxide-sensitive pulmonary hypertension in congenital rubella syndrome. Case reports in critical care, 2015198570. https://doi.org/10.1155/2015/198570
Raimondi, Francesco, et al. "Nitric oxide-sensitive pulmonary hypertension in congenital rubella syndrome." Case reports in critical care vol. 2015 (2015): 198570. doi: https://doi.org/10.1155/2015/198570
Raimondi F, Migliaro F, Di Pietro E, Borgia F, Rapacciuolo A, Capasso L. Nitric oxide-sensitive pulmonary hypertension in congenital rubella syndrome. Case Rep Crit Care. 2015;2015:198570. doi: 10.1155/2015/198570. Epub 2015 Feb 16. PMID: 25785205; PMCID: PMC4345243.
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Case Rep Crit Care. 2015;2015:198570. doi: 10.1155/2015/198570. Epub 2015 Feb 16.

Nitric oxide-sensitive pulmonary hypertension in congenital rubella syndrome.

Case reports in critical care

Francesco Raimondi, Fiorella Migliaro, Elisa Di Pietro, Francesco Borgia, Antonio Rapacciuolo, Letizia Capasso

Affiliations

  1. Division of Neonatology, Section of Pediatrics, Department of Translational Medical Sciences, Università "Federico II", Via Pansini 5, 80131 Naples, Italy.
  2. Division of Cardiology, Department of Advanced Biomedical Sciences, Università "Federico II", Via Pansini 5, 80131 Naples, Italy.

PMID: 25785205 PMCID: PMC4345243 DOI: 10.1155/2015/198570

Abstract

Persistent pulmonary hypertension is a very rare presentation of congenital virus infection. We discuss the case of complete congenital rubella syndrome presenting at echocardiography with pulmonary hypertension that worsened after ductus ligation. Cardiac catheterization showed a normal pulmonary valve and vascular tree but a PAP = 40 mmHg. The infant promptly responded to inhaled nitric oxide while on mechanical ventilation and was later shifted to oral sildenafil. It is not clear whether our observation may be due to direct viral damage to the endothelium or to the rubella virus increasing the vascular tone via a metabolic derangement.

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