Display options
Cite
Back HM, Song B, Chae JW, et al. Determination of Matrine in Rat Plasma after Oral Administration of Novel Korean Herbal Medicine KIOM-MA128 and Application of PK. J Anal Methods Chem. 2015;2015:431632doi: 10.1155/2015/431632.
Back, H. M., Song, B., Chae, J. W., Yun, H. Y., Ma, J. Y., & Kwon, K. I. (2015). Determination of Matrine in Rat Plasma after Oral Administration of Novel Korean Herbal Medicine KIOM-MA128 and Application of PK. Journal of analytical methods in chemistry, 2015431632. https://doi.org/10.1155/2015/431632
Back, Hyun-Moon, et al. "Determination of Matrine in Rat Plasma after Oral Administration of Novel Korean Herbal Medicine KIOM-MA128 and Application of PK." Journal of analytical methods in chemistry vol. 2015 (2015): 431632. doi: https://doi.org/10.1155/2015/431632
Back HM, Song B, Chae JW, Yun HY, Ma JY, Kwon KI. Determination of Matrine in Rat Plasma after Oral Administration of Novel Korean Herbal Medicine KIOM-MA128 and Application of PK. J Anal Methods Chem. 2015;2015:431632. doi: 10.1155/2015/431632. Epub 2015 Feb 16. PMID: 25785230; PMCID: PMC4345259.
Copy Download .nbib Format: NLM
Share it on

J Anal Methods Chem. 2015;2015:431632. doi: 10.1155/2015/431632. Epub 2015 Feb 16.

Determination of Matrine in Rat Plasma after Oral Administration of Novel Korean Herbal Medicine KIOM-MA128 and Application of PK.

Journal of analytical methods in chemistry

Hyun-Moon Back, Byungjeong Song, Jung-Woo Chae, Hwi-Yeol Yun, Jin Yeul Ma, Kwang-Il Kwon

Affiliations

  1. College of Pharmacy, Chungnam National University, Daejeon 305-764, Republic of Korea.
  2. Herbal Medicine Improvement Research Center, Korea Institute of Oriental Medicine, Daejeon 305-811, Republic of Korea.

PMID: 25785230 PMCID: PMC4345259 DOI: 10.1155/2015/431632

Abstract

KIOM-MA128 is a novel Korean herbal medicine with antiatopic, anti-inflammatory, and antiasthmatic effects. Matrine is thought to be a potential chemical marker of KIOM-MA128, but pharmacokinetic studies on KIOM-MA128 had not been performed. This study describes a simple and rapid method using high-performance liquid chromatography-tandem mass spectrometry (HPLC-MS/MS) to determine the concentration of matrine in rats plasma after administration of KIOM-MA128. The isocratic mobile phase consisted of methanol and distilled water, and the flow rate was 0.15 mL/min. The accuracy and precision of the assay, as well as stability tests, were performed in accordance with FDA regulations for the validation of bioanalytical methods. The half-life and T max of matrine after administration of KIOM-MA128 were 4.29 ± 2.20 h and 1.8 ± 1.23 h, respectively. C max and AUCinf of matrine after administration of KIOM-MA128 at 4 g/kg and 8 g/kg were 595.10 ± 182.91 ng/mL, 5336.77 ± 1503.84 ng/mL·h and 850.46 ± 120 ng/mL, 9583.10 ± 888.92 ng/mL·h, respectively. The validated method was successfully applied to a pharmacokinetic study in rats after oral administration of KIOM-MA128.

References

  1. Lancet. 1998 Jun 6;351(9117):1715-21 - PubMed
  2. J Am Acad Dermatol. 2001 Jan;44(1 Suppl):S17-27 - PubMed
  3. J Am Acad Dermatol. 2006 Jan;54(1):1-15; quiz 16-8 - PubMed
  4. Acta Derm Venereol. 1960;40:285-306 - PubMed
  5. Evid Based Complement Alternat Med. 2012;2012:769508 - PubMed
  6. Clin Microbiol Rev. 2002 Oct;15(4):545-63 - PubMed
  7. Curr Opin Immunol. 2000 Dec;12(6):641-6 - PubMed
  8. J Immunol. 2002 Feb 15;168(4):2020-7 - PubMed
  9. Int Immunopharmacol. 2007 Jun;7(6):816-23 - PubMed
  10. Evid Based Complement Alternat Med. 2012;2012:462383 - PubMed
  11. Clin Exp Dermatol. 2000 Oct;25(7):559-66 - PubMed
  12. J Dermatol. 2004 Apr;31(4):277-83 - PubMed
  13. Immunol Today. 1998 Aug;19(8):359-61 - PubMed
  14. Evid Based Complement Alternat Med. 2012;2012:762918 - PubMed
  15. Photodermatol Photoimmunol Photomed. 2007 Aug;23(4):135-44 - PubMed

Publication Types