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Makino S, Uchihashi T, Kataoka Y, et al. Recovery from alopecia areata in a patient with autoimmune polyglandular syndrome type 3. Endocrinol Diabetes Metab Case Rep. 2015;2015:140084doi: 10.1530/EDM-14-0084.
Makino, S., Uchihashi, T., Kataoka, Y., & Fujiwara, M. (2015). Recovery from alopecia areata in a patient with autoimmune polyglandular syndrome type 3. Endocrinology, diabetes & metabolism case reports, 2015140084. https://doi.org/10.1530/EDM-14-0084
Makino, Shinya, et al. "Recovery from alopecia areata in a patient with autoimmune polyglandular syndrome type 3." Endocrinology, diabetes & metabolism case reports vol. 2015 (2015): 140084. doi: https://doi.org/10.1530/EDM-14-0084
Makino S, Uchihashi T, Kataoka Y, Fujiwara M. Recovery from alopecia areata in a patient with autoimmune polyglandular syndrome type 3. Endocrinol Diabetes Metab Case Rep. 2015;2015:140084. doi: 10.1530/EDM-14-0084. Epub 2015 Feb 01. PMID: 25759758; PMCID: PMC4342500.
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Endocrinol Diabetes Metab Case Rep. 2015;2015:140084. doi: 10.1530/EDM-14-0084. Epub 2015 Feb 01.

Recovery from alopecia areata in a patient with autoimmune polyglandular syndrome type 3.

Endocrinology, diabetes & metabolism case reports

Shinya Makino, Takeshi Uchihashi, Yasuo Kataoka, Masayoshi Fujiwara

Affiliations

  1. Department of Internal Medicine, Osaka Gyomeikan Hospital , 5-4-8 Nishikujo, Konohana-ku, Osaka, 554-0012 , Japan.

PMID: 25759758 PMCID: PMC4342500 DOI: 10.1530/EDM-14-0084

Abstract

UNLABELLED: Recovery from alopecia is rare in autoimmune polyglandular syndrome (APS). A 41-year-old male was admitted to our hospital with hyperglycemia. He developed alopecia areata (AA) 5 months before admission and developed thirst, polyuria, and anorexia in 2 weeks. His plasma glucose level upon admission was 912 mg/dl (50.63 mmol/l) and HbA1c was 13.7%. Although urinary and plasma C-peptide levels showed that insulin secretion was not depleted, anti-insulinoma-associated antigen 2 antibody was present. In addition, measurement of thyroid autoantibodies revealed the presence of Hashimoto's thyroiditis. These findings suggested a diagnosis of APS type 3. The patient has showed signs of improvement with the continuation of insulin therapy. During the successful control of diabetes, he had total hair regrowth within 2-3 months. Human leukocyte antigen typing showed that DRB1*1501-DQB1*0602 and DQB1*0301 were present. Similar cases should be accumulated to clarify the association of APS type 3 with recovery from AA.

LEARNING POINTS: Alopecia in diabetic patients is a suspicious manifestation of autoimmune type 1 diabetes.Patients with autoimmune type 1 diabetes specifically manifesting alopecia should be further examined for diagnosis of APS.Insulin-mediated metabolic improvement may be a factor, but not the sole factor, determining a favorable outcome of alopecia in patients with autoimmune type 1 diabetes.

References

  1. J Crohns Colitis. 2013 May;7(4):318-21 - PubMed
  2. Medicine (Baltimore). 1981 Sep;60(5):355-62 - PubMed
  3. Am J Med Sci. 1991 Apr;301(4):269-71 - PubMed
  4. Diabetes Res Clin Pract. 2003 Aug;61(2):103-8 - PubMed
  5. Horm Res. 2005;64(5):253-60 - PubMed
  6. J Diabetes Investig. 2014 Feb 12;5(1):115-8 - PubMed
  7. Lancet. 1978 Jul 29;2(8083):268 - PubMed
  8. Endocr Rev. 2002 Jun;23(3):327-64 - PubMed
  9. J Am Acad Dermatol. 2006 Sep;55(3):438-41 - PubMed
  10. Endocr Pract. 2009 Mar;15(2):138-42 - PubMed
  11. BMJ Case Rep. 2010 Oct 21;2010:null - PubMed
  12. J Clin Endocrinol Metab. 2012 Jun;97(6):E1043-50 - PubMed
  13. Curr Opin Pediatr. 2009 Aug;21(4):475-80 - PubMed
  14. Eur J Dermatol. 2004 Nov-Dec;14(6):364-70 - PubMed

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