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Lamberti M, Uccello R, Monaco MGL, et al. Tuberculin skin test and Quantiferon test agreement and influencing factors in tuberculosis screening of healthcare workers: a systematic review and meta-analysis. J Occup Med Toxicol. 2015;10:2doi: 10.1186/s12995-015-0044-y.
Lamberti, M., Uccello, R., Monaco, M. G. L., Muoio, M., Feola, D., Sannolo, N., Nienhaus, A., & Chiodini, P. (2015). Tuberculin skin test and Quantiferon test agreement and influencing factors in tuberculosis screening of healthcare workers: a systematic review and meta-analysis. Journal of occupational medicine and toxicology (London, England), 102. https://doi.org/10.1186/s12995-015-0044-y
Lamberti, Monica, et al. "Tuberculin skin test and Quantiferon test agreement and influencing factors in tuberculosis screening of healthcare workers: a systematic review and meta-analysis." Journal of occupational medicine and toxicology (London, England) vol. 10 (2015): 2. doi: https://doi.org/10.1186/s12995-015-0044-y
Lamberti M, Uccello R, Monaco MGL, Muoio M, Feola D, Sannolo N, Nienhaus A, Chiodini P. Tuberculin skin test and Quantiferon test agreement and influencing factors in tuberculosis screening of healthcare workers: a systematic review and meta-analysis. J Occup Med Toxicol. 2015 Jan 27;10:2. doi: 10.1186/s12995-015-0044-y. eCollection 2015. PMID: 25670962; PMCID: PMC4323208.
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J Occup Med Toxicol. 2015 Jan 27;10:2. doi: 10.1186/s12995-015-0044-y. eCollection 2015.

Tuberculin skin test and Quantiferon test agreement and influencing factors in tuberculosis screening of healthcare workers: a systematic review and meta-analysis.

Journal of occupational medicine and toxicology (London, England)

Monica Lamberti, Rossella Uccello, Maria Grazia Lourdes Monaco, Mariarosaria Muoio, Daniela Feola, Nicola Sannolo, Albert Nienhaus, Paolo Chiodini

Affiliations

  1. Department of Experimental Medicine, Section of Hygiene, Occupational Medicine and Forensic, Medicine, Second University of Naples, Naples, Italy.
  2. Center of Excellence for Epidemiology and Health Services Research for Healthcare Professionals (CVcare), Institute for Health Service Research in Dermatology and Nursing, University Medical Center Hamburg-Eppendorf, Hamburg, Germany.
  3. Principles of Prevention and Rehabilitation Department (GPR), Institute for Statutory Accident Insurance and Prevention in the Health and Welfare Services (BGW), Hamburg, Germany.
  4. Medical Statistics Unit, Second University of Naples, Naples, Italy.

PMID: 25670962 PMCID: PMC4323208 DOI: 10.1186/s12995-015-0044-y

Abstract

OBJECTIVE: A systematic review and meta-analysis was conducted to evaluate the agreement between Tuberculin Skin Test (TST) and Quantiferon (QFT) in screening for tuberculosis (TB) infection among healthcare workers (HCWs) and to estimate associations between TST and QFT agreement and variables of interest, such as Bacillus Calmette-Guérin (BCG) vaccination and incidence of TB.

METHODS: Cross-sectional and longitudinal studies on HCWs, published in English until October 2013, comparing TST and QFT results, were selected. For each study Cohen's κ value and a 95% confidence interval were calculated. Summary measures and indexes of heterogeneity between studies were calculated.

RESULTS: 29 studies were selected comprising a total of 11,434 HCWs. Cohen's κ for agreement between TST and QFT for 24 of them was 0.28 (95% CI 0.22 to 0.35), with the best value in high TB incidence countries and the lowest rate of BCG vaccination.

CONCLUSION: Currently, there is no gold standard for TB screening and the most-used diagnostic tools show low agreement. For evidence-based health surveillance in HCWs, occupational physicians need to consider a number of factors influencing screening results, such as TB incidence, vaccination status, age and working seniority.

Keywords: Cohen’s k; Health surveillance; Healthcare workers; Meta-analysis; Quantiferon TB Gold; Tuberculin skin test; Tuberculosis

References

  1. J Occup Med Toxicol. 2011 Jun 09;6:19 - PubMed
  2. Pulm Med. 2013;2013:601737 - PubMed
  3. Lung. 2009 Nov-Dec;187(6):413-9 - PubMed
  4. Infect Control Hosp Epidemiol. 2009 Mar;30(3):215-21 - PubMed
  5. Stat Med. 2004 Jun 15;23(11):1663-82 - PubMed
  6. Scand J Infect Dis. 2007;39(6-7):554-9 - PubMed
  7. Jpn J Infect Dis. 2007 May;60(2-3):102-5 - PubMed
  8. J Clin Epidemiol. 2009 Oct;62(10):1006-12 - PubMed
  9. Infect Control Hosp Epidemiol. 2009 Sep;30(9):876-83 - PubMed
  10. BMC Infect Dis. 2011 Jan 18;11:19 - PubMed
  11. Eur Respir J. 2011 Jan;37(1):88-99 - PubMed
  12. J Occup Med Toxicol. 2009 Nov 30;4:30 - PubMed
  13. PLoS One. 2007 Aug 29;2(8):e803 - PubMed
  14. PLoS Med. 2006 Dec;3(12):e494 - PubMed
  15. PLoS One. 2009 Aug 24;4(8):e6686 - PubMed
  16. Bull World Health Organ. 1964;31:161-70 - PubMed
  17. Tuberc Respir Dis (Seoul). 2013 Jul;75(1):18-24 - PubMed
  18. MMWR Recomm Rep. 2005 Dec 16;54(RR-15):49-55 - PubMed
  19. Proc Am Thorac Soc. 2006;3(1):103-10 - PubMed
  20. Int J Tuberc Lung Dis. 2008 Aug;12(8):895-902 - PubMed
  21. Tuberc Respir Dis (Seoul). 2012 Oct;73(4):219-23 - PubMed
  22. PLoS One. 2013;8(3):e58202 - PubMed
  23. Thorax. 2002 Sep;57(9):804-9 - PubMed
  24. Clin Microbiol Rev. 2014 Jan;27(1):3-20 - PubMed
  25. Int J Tuberc Lung Dis. 2012 Nov;16(11):1485-91 - PubMed
  26. Int J Tuberc Lung Dis. 2007 Jun;11(6):593-605 - PubMed
  27. Int J Occup Med Environ Health. 2011 Dec;24(4):359-66 - PubMed
  28. Stat Med. 2002 Feb 28;21(4):589-624 - PubMed
  29. Scand J Infect Dis. 2010 Sep;42(9):672-8 - PubMed
  30. Am J Clin Pathol. 2009 Nov;132(5):678-86 - PubMed
  31. J Occup Environ Med. 2011 Mar;53(3):290-3 - PubMed
  32. MMWR Recomm Rep. 2005 Dec 30;54(RR-17):1-141 - PubMed
  33. Int J Tuberc Lung Dis. 2008 May;12(5):513-9 - PubMed
  34. PLoS One. 2012;7(8):e43014 - PubMed
  35. Int J Tuberc Lung Dis. 2013 Oct;17(10):1273-8 - PubMed
  36. Stat Med. 1999 Oct 30;18(20):2693-708 - PubMed
  37. Arch Med Res. 2009 Feb;40(2):103-8 - PubMed
  38. Med Lav. 2012 Jan-Feb;103(1):26-36 - PubMed
  39. J Gen Intern Med. 2012 Jun;27 Suppl 1:S67-75 - PubMed
  40. Emerg Infect Dis. 2011 Mar;17(3):488-94 - PubMed
  41. PLoS One. 2009 Aug 27;4(8):e6798 - PubMed
  42. J Clin Lab Anal. 2011 Nov;25(6):382-8 - PubMed
  43. Infect Control Hosp Epidemiol. 2009 Dec;30(12):1218-22 - PubMed
  44. N Z Med J. 2012 Feb 10;125(1349):21-9 - PubMed
  45. Euro Surveill. 2009 Oct 29;14(43):null - PubMed
  46. Clin Chem. 2014 May;60(5):714-8 - PubMed
  47. Ann Am Thorac Soc. 2014 Mar;11(3):399-401 - PubMed
  48. Thorax. 2012 Jan;67(1):62-70 - PubMed
  49. Int Arch Occup Environ Health. 2008 Jan;81(3):295-300 - PubMed
  50. Chest. 2008 Jun;133(6):1415-20 - PubMed
  51. Respiration. 2005 Jul-Aug;72(4):431-46 - PubMed

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