Display options
Cite
Johnson GA, Burghardt RC, Bazer FW. Osteopontin: a leading candidate adhesion molecule for implantation in pigs and sheep. J Anim Sci Biotechnol. 2014;5(1):56doi: 10.1186/2049-1891-5-56.
Johnson, G. A., Burghardt, R. C., & Bazer, F. W. (2014). Osteopontin: a leading candidate adhesion molecule for implantation in pigs and sheep. Journal of animal science and biotechnology, 5(1), 56. https://doi.org/10.1186/2049-1891-5-56
Johnson, Greg A, et al. "Osteopontin: a leading candidate adhesion molecule for implantation in pigs and sheep." Journal of animal science and biotechnology vol. 5,1 (2014): 56. doi: https://doi.org/10.1186/2049-1891-5-56
Johnson GA, Burghardt RC, Bazer FW. Osteopontin: a leading candidate adhesion molecule for implantation in pigs and sheep. J Anim Sci Biotechnol. 2014 Dec 17;5(1):56. doi: 10.1186/2049-1891-5-56. eCollection 2014. PMID: 25671104; PMCID: PMC4322467.
Copy Download .nbib Format: NLM
Share it on

J Anim Sci Biotechnol. 2014 Dec 17;5(1):56. doi: 10.1186/2049-1891-5-56. eCollection 2014.

Osteopontin: a leading candidate adhesion molecule for implantation in pigs and sheep.

Journal of animal science and biotechnology

Greg A Johnson, Robert C Burghardt, Fuller W Bazer

Affiliations

  1. Department of Veterinary Integrative Biosciences, Texas A&M University, College Station, TX 77843-4458 USA.
  2. Department of Animal Science, Texas A&M University, College Station, TX 77843 USA.

PMID: 25671104 PMCID: PMC4322467 DOI: 10.1186/2049-1891-5-56

Abstract

Osteopontin (OPN; also known as Secreted Phosphoprotein 1, SPP1) is a secreted extra-cellular matrix (ECM) protein that binds to a variety of cell surface integrins to stimulate cell-cell and cell-ECM adhesion and communication. It is generally accepted that OPN interacts with apically expressed integrin receptors on the uterine luminal epithelium (LE) and conceptus trophectoderm to attach the conceptus to the uterus for implantation. Research conducted with pigs and sheep has significantly advanced understanding of the role(s) of OPN during implantation through exploitation of the prolonged peri-implantation period of pregnancy when elongating conceptuses are free within the uterine lumen requiring extensive paracrine signaling between conceptus and endometrium. This is followed by a protracted and incremental attachment cascade of trophectoderm to uterine LE during implantation, and development of a true epitheliochorial or synepitheliochorial placenta exhibited by pigs and sheep, respectively. In pigs, implanting conceptuses secrete estrogens which induce the synthesis and secretion of OPN in adjacent uterine LE. OPN then binds to αvβ6 integrin receptors on trophectoderm, and the αvβ3 integrin receptors on uterine LE to bridge conceptus attachment to uterine LE for implantation. In sheep, implanting conceptuses secrete interferon tau that prolongs the lifespan of CL. Progesterone released by CL then induces OPN synthesis and secretion from the endometrial GE into the uterine lumen where OPN binds integrins expressed on trophectoderm (αvβ3) and uterine LE (identity of specific integrins unknown) to adhere the conceptus to the uterus for implantation. OPN binding to the αvβ3 integrin receptor on ovine trophectoderm cells induces in vitro focal adhesion assembly, a prerequisite for adhesion and migration of trophectoderm, through activation of: 1) P70S6K via crosstalk between FRAP1/MTOR and MAPK pathways; 2) MTOR, PI3K, MAPK3/MAPK1 (Erk1/2) and MAPK14 (p38) signaling to stimulate trohectoderm cell migration; and 3) focal adhesion assembly and myosin II motor activity to induce migration of trophectoderm cells. Further large in vivo focal adhesions assemble at the uterine-placental interface of both pigs and sheep and identify the involvement of sizable mechanical forces at this interface during discrete periods of trophoblast migration, attachment and placentation in both species.

Keywords: Implantation; Integrins; Pigs; Psteoponti; Sheep

References

  1. J Reprod Fertil. 1984 May;71(1):57-64 - PubMed
  2. Biol Reprod. 1989 Feb;40(2):425-33 - PubMed
  3. Reproduction. 2009 Mar;137(3):567-82 - PubMed
  4. Matrix Biol. 2010 Jun;29(5):369-82 - PubMed
  5. Matrix Biol. 2000 Dec;19(7):615-22 - PubMed
  6. Biochim Biophys Acta. 1989 Jun 13;996(1-2):43-8 - PubMed
  7. Biol Reprod. 2001 Sep;65(3):820-8 - PubMed
  8. Cell. 1987 Feb 27;48(4):549-54 - PubMed
  9. Science. 2009 Apr 24;324(5926):468-9 - PubMed
  10. J Biol Chem. 1998 Nov 6;273(45):29935-41 - PubMed
  11. J Biol Chem. 1999 Jan 15;274(3):1729-35 - PubMed
  12. Hum Reprod. 2005 Aug;20(8):2104-17 - PubMed
  13. Biol Reprod. 2001 Jun;64(6):1608-13 - PubMed
  14. Biol Reprod. 2003 Nov;69(5):1458-71 - PubMed
  15. Am J Physiol. 1983 Dec;245(6):R850-2 - PubMed
  16. Biochim Biophys Acta. 1996 Nov 8;1314(1-2):13-24 - PubMed
  17. Reproduction. 2006 Dec;132(6):919-29 - PubMed
  18. J Cell Sci. 1998 May;111 ( Pt 9):1165-74 - PubMed
  19. FASEB J. 1993 Dec;7(15):1475-82 - PubMed
  20. Exp Cell Res. 1992 Aug;201(2):526-30 - PubMed
  21. Mol Reprod Dev. 1992 Aug;32(4):315-23 - PubMed
  22. Acta Anat (Basel). 1984;118(2):96-106 - PubMed
  23. Fertil Steril. 1994 Sep;62(3):497-506 - PubMed
  24. Toxicol Pathol. 2006;34(4):373-84 - PubMed
  25. Endocrinology. 2001 Jun;142(6):2303-10 - PubMed
  26. J Biol Chem. 2001 Jul 27;276(30):28261-7 - PubMed
  27. Biol Reprod. 1999 Oct;61(4):892-9 - PubMed
  28. Science. 1996 Jan 26;271(5248):509-12 - PubMed
  29. Biol Reprod. 2005 Dec;73(6):1294-301 - PubMed
  30. Differentiation. 2014 Jan-Feb;87(1-2):52-65 - PubMed
  31. Mol Biol Cell. 1998 Jun;9(6):1425-35 - PubMed
  32. J Biol Chem. 1995 Apr 28;270(17):9917-25 - PubMed
  33. Placenta. 2005 Feb-Mar;26(2-3):160-70 - PubMed
  34. J Biol Chem. 2000 Jul 14;275(28):20959-62 - PubMed
  35. Cells Tissues Organs. 2002;172(3):202-17 - PubMed
  36. Connect Tissue Res. 1989;23(2-3):123-36 - PubMed
  37. PLoS One. 2014 Jun 25;9(6):e100106 - PubMed
  38. Biol Reprod. 2003 May;68(5):1484-90 - PubMed
  39. Mol Biol Cell. 1994 May;5(5):565-74 - PubMed
  40. Dev Biol. 2000 Jul 15;223(2):217-37 - PubMed
  41. J Anim Sci. 1983 Jul;57 Suppl 2:425-60 - PubMed
  42. Biol Reprod. 2002 May;66(5):1437-48 - PubMed
  43. Ann Biomed Eng. 2002 Jun;30(6):840-50 - PubMed
  44. J Biol Chem. 1995 Nov 24;270(47):28471-8 - PubMed
  45. Hum Reprod. 2014 Apr;29(4):739-49 - PubMed
  46. Nat Rev Mol Cell Biol. 2009 Jan;10(1):21-33 - PubMed
  47. Endocrinology. 1995 Jul;136(7):2984-92 - PubMed
  48. Genomics. 1990 Aug;7(4):491-502 - PubMed
  49. Biol Reprod. 2002 Mar;66(3):718-25 - PubMed
  50. Endocrinology. 1996 May;137(5):1785-90 - PubMed
  51. Biochem Biophys Res Commun. 1989 Nov 30;165(1):234-40 - PubMed
  52. Biochem J. 1985 Dec 15;232(3):715-24 - PubMed
  53. J Clin Endocrinol Metab. 2002 Jun;87(6):2954-9 - PubMed
  54. Reproduction. 2002 Aug;124(2):289-300 - PubMed
  55. Endocrinology. 1997 Oct;138(10):4308-15 - PubMed
  56. Endocrinology. 2003 Jun;144(6):2254-65 - PubMed
  57. Science. 2000 Feb 4;287(5454):860-4 - PubMed
  58. Biol Reprod. 2003 Jun;68(6):1951-8 - PubMed
  59. J Reprod Fertil. 1988 Mar;82(2):875-92 - PubMed
  60. Reproduction. 2010 Oct;140(4):595-604 - PubMed
  61. J Reprod Immunol. 2002 May-Jun;55(1-2):101-12 - PubMed
  62. J Clin Invest. 1992 Jul;90(1):188-95 - PubMed
  63. Biol Reprod. 1997 Feb;56(2):348-56 - PubMed
  64. Biol Reprod. 2007 Jul;77(1):172-80 - PubMed
  65. Reproduction. 2010 Oct;140(4):583-94 - PubMed
  66. Biol Reprod. 2003 Mar;68(3):766-71 - PubMed
  67. Biochem Biophys Res Commun. 2001 Jan 19;280(2):460-5 - PubMed
  68. Endocrinology. 2002 Jun;143(6):2119-38 - PubMed
  69. Prostaglandins. 1977 Aug;14(2):397-400 - PubMed
  70. Am J Reprod Immunol. 1996 Mar;35(3):195-204 - PubMed
  71. Microsc Res Tech. 1993 Jun 1;25(2):106-20 - PubMed
  72. J Reprod Fertil. 1995 Jan;103(1):75-87 - PubMed
  73. Cancer. 2002 Aug 1;95(3):506-12 - PubMed
  74. J Biol Chem. 1974 Dec 10;249(23 ):7574-9 - PubMed
  75. Biol Reprod. 2009 Nov;81(5):814-25 - PubMed
  76. Fertil Steril. 1996 Mar;65(3):477-83 - PubMed
  77. Biol Reprod. 1999 Oct;61(4):884-91 - PubMed
  78. Gene. 1991 Apr;100:163-71 - PubMed
  79. J Cell Biol. 1988 Feb;106(2):441-50 - PubMed
  80. Crit Rev Oral Biol Med. 2000;11(3):279-303 - PubMed
  81. J Reprod Fertil. 1988 Nov;84(2):493-504 - PubMed
  82. Arterioscler Thromb. 1992 Sep;12(9):997-1007 - PubMed
  83. J Biol Chem. 2001 Apr 20;276(16):13483-9 - PubMed
  84. Acta Anat Suppl (Basel). 1973;61:1-22 - PubMed
  85. Annu Rev Biophys Biomol Struct. 2006;35:459-88 - PubMed
  86. Reproduction. 2010 Feb;139(2):465-78 - PubMed
  87. Science. 1994 Dec 2;266(5190):1508-18 - PubMed
  88. J Exp Med. 1989 Jul 1;170(1):145-61 - PubMed
  89. J Biol Chem. 1994 Jan 7;269(1):711-5 - PubMed
  90. Science. 1999 Aug 13;285(5430):1028-32 - PubMed
  91. J Biol Chem. 1995 Nov 3;270(44):26232-8 - PubMed
  92. Reproduction. 2007 Jun;133(6):1213-21 - PubMed
  93. Ann N Y Acad Sci. 1994 Sep 30;734:103-21 - PubMed
  94. Cell. 1981 Jan;23(1):19-28 - PubMed
  95. Biol Reprod. 2000 May;62(5):1285-90 - PubMed
  96. Soc Reprod Fertil Suppl. 2009;66:321-32 - PubMed
  97. Fertil Steril. 1995 Mar;63(3):535-42 - PubMed
  98. Protein Sci. 1995 Oct;4(10):2040-9 - PubMed
  99. J Cell Biochem. 1995 Apr;57(4):680-90 - PubMed
  100. Biochem Soc Trans. 2001 May;29(Pt 2):153-6 - PubMed
  101. J Clin Invest. 2001 May;107(9):1055-61 - PubMed
  102. Biol Reprod. 1982 Dec;27(5):1247-60 - PubMed
  103. Science. 1987 Oct 23;238(4826):491-7 - PubMed
  104. Prostaglandins. 1977;14(6):1183-96 - PubMed
  105. Mol Hum Reprod. 2002 Sep;8(9):871-9 - PubMed
  106. Biol Reprod. 2003 Jun;68(6):2172-9 - PubMed
  107. Biol Reprod. 1990 Oct;43(4):592-9 - PubMed
  108. Biol Reprod. 1996 Nov;55(5):1098-106 - PubMed
  109. Reproduction. 2004 Dec;128(6):657-68 - PubMed
  110. Exp Cell Res. 1998 Jul 10;242(1):351-60 - PubMed
  111. J Reprod Fertil. 1969 Jun;19(1):51-61 - PubMed
  112. J Biol Chem. 1989 Jun 5;264(16):9682-9 - PubMed
  113. J Clin Endocrinol Metab. 2001 Oct;86(10):4991-5000 - PubMed
  114. Biol Reprod. 2003 Jul;69(1):92-8 - PubMed
  115. Biol Reprod. 1999 Dec;61(6):1409-18 - PubMed
  116. J Exp Med. 1981 Nov 1;154(5):1681-93 - PubMed
  117. J Biol Chem. 1993 Jul 15;268(20):15180-4 - PubMed
  118. J Bone Miner Res. 1995 Dec;10(12):1913-29 - PubMed
  119. Mol Endocrinol. 1988 Dec;2(12):1169-75 - PubMed
  120. J Reprod Fertil Suppl. 1997;52:151-64 - PubMed
  121. Mol Biol Cell. 1992 Oct;3(10):1169-80 - PubMed
  122. Biol Reprod. 2000 May;62(5):1315-21 - PubMed
  123. J Exp Zool. 1993 Sep 1;266(6):541-58 - PubMed
  124. Semin Cell Dev Biol. 2000 Apr;11(2):77-92 - PubMed
  125. J Biol Chem. 1987 Feb 25;262(6):2900-7 - PubMed
  126. Biol Reprod. 2013 May 16;88(5):120 - PubMed
  127. Cell. 1979 Apr;16(4):885-93 - PubMed

Publication Types