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Ostermann J, Schmidtke C, Wolter C, et al. Tailoring the ligand shell for the control of cellular uptake and optical properties of nanocrystals. Beilstein J Nanotechnol. 2015;6:232-42doi: 10.3762/bjnano.6.22.
Ostermann, J., Schmidtke, C., Wolter, C., Merkl, J. P., Kloust, H., & Weller, H. (2015). Tailoring the ligand shell for the control of cellular uptake and optical properties of nanocrystals. Beilstein journal of nanotechnology, 6232-42. https://doi.org/10.3762/bjnano.6.22
Ostermann, Johannes, et al. "Tailoring the ligand shell for the control of cellular uptake and optical properties of nanocrystals." Beilstein journal of nanotechnology vol. 6 (2015): 232-42. doi: https://doi.org/10.3762/bjnano.6.22
Ostermann J, Schmidtke C, Wolter C, Merkl JP, Kloust H, Weller H. Tailoring the ligand shell for the control of cellular uptake and optical properties of nanocrystals. Beilstein J Nanotechnol. 2015 Jan 21;6:232-42. doi: 10.3762/bjnano.6.22. eCollection 2015. PMID: 25671167; PMCID: PMC4311591.
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Beilstein J Nanotechnol. 2015 Jan 21;6:232-42. doi: 10.3762/bjnano.6.22. eCollection 2015.

Tailoring the ligand shell for the control of cellular uptake and optical properties of nanocrystals.

Beilstein journal of nanotechnology

Johannes Ostermann, Christian Schmidtke, Christopher Wolter, Jan-Philip Merkl, Hauke Kloust, Horst Weller

Affiliations

  1. Institute for Physical Chemistry, University of Hamburg, Grindelallee 117, 20146 Hamburg, Germany.
  2. Institute for Physical Chemistry, University of Hamburg, Grindelallee 117, 20146 Hamburg, Germany ; Center for Applied Nanotechnology, Grindelallee 117, 20146 Hamburg, Germany ; The Hamburg Centre for Ultrafast Imaging, University of Hamburg, Luruper Chaussee 149, 22761 Hamburg, Germany ; Department of Chemistry, Faculty of Science, King Abdulaziz University, Jeddah, Saudi Arabia.

PMID: 25671167 PMCID: PMC4311591 DOI: 10.3762/bjnano.6.22

Abstract

In this short review, the main challenges in the use of hydrophobic nanoparticles in biomedical application are addressed. It is shown how to overcome the different issues by the use of a polymeric encapsulation system, based on an amphiphilic polyisoprene-block-poly(ethylene glycol) diblock copolymer. On the basis of this simple molecule, the development of a versatile and powerful phase transfer strategy is summarized, focusing on the main advantages like the adjustable size, the retained properties, the excellent shielding and the diverse functionalization properties of the encapsulated nanoparticles. Finally, the extraordinary properties of these encapsulated nanoparticles in terms of toxicity and specificity in a broad in vitro test is demonstrated.

Keywords: biolable; cellular uptake; fluorescence quenching; poylmeric micelles; quantum dots

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