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Seo JY, Park YJ, Yi YA, et al. Epigenetics: general characteristics and implications for oral health. Restor Dent Endod. 2014;40(1):14-22doi: 10.5395/rde.2015.40.1.14.
Seo, J. Y., Park, Y. J., Yi, Y. A., Hwang, J. Y., Lee, I. B., Cho, B. H., Son, H. H., & Seo, D. G. (2015). Epigenetics: general characteristics and implications for oral health. Restorative dentistry & endodontics, 40(1), 14-22. https://doi.org/10.5395/rde.2015.40.1.14
Seo, Ji-Yun, et al. "Epigenetics: general characteristics and implications for oral health." Restorative dentistry & endodontics vol. 40,1 (2015): 14-22. doi: https://doi.org/10.5395/rde.2015.40.1.14
Seo JY, Park YJ, Yi YA, Hwang JY, Lee IB, Cho BH, Son HH, Seo DG. Epigenetics: general characteristics and implications for oral health. Restor Dent Endod. 2015 Feb;40(1):14-22. doi: 10.5395/rde.2015.40.1.14. Epub 2014 Nov 13. PMID: 25671208; PMCID: PMC4320272.
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Restor Dent Endod. 2015 Feb;40(1):14-22. doi: 10.5395/rde.2015.40.1.14. Epub 2014 Nov 13.

Epigenetics: general characteristics and implications for oral health.

Restorative dentistry & endodontics

Ji-Yun Seo, Yoon-Jung Park, Young-Ah Yi, Ji-Yun Hwang, In-Bog Lee, Byeong-Hoon Cho, Ho-Hyun Son, Deog-Gyu Seo

Affiliations

  1. Department of Conservative Dentistry, Seoul National University School of Dentistry and Dental Research Institute, Seoul, Korea.
  2. Department of Nutritional Science and Food Management, Ewha Womans University, Seoul, Korea.
  3. Department of Dentistry, Inje University Seoul Paik Hospital, Seoul, Korea.
  4. Nutrition Education Major, Graduate School of Education, Sangmyung University, Seoul, Korea.

PMID: 25671208 PMCID: PMC4320272 DOI: 10.5395/rde.2015.40.1.14

Abstract

Genetic information such as DNA sequences has been limited to fully explain mechanisms of gene regulation and disease process. Epigenetic mechanisms, which include DNA methylation, histone modification and non-coding RNAs, can regulate gene expression and affect progression of disease. Although studies focused on epigenetics are being actively investigated in the field of medicine and biology, epigenetics in dental research is at the early stages. However, studies on epigenetics in dentistry deserve attention because epigenetic mechanisms play important roles in gene expression during tooth development and may affect oral diseases. In addition, understanding of epigenetic alteration is important for developing new therapeutic methods. This review article aims to outline the general features of epigenetic mechanisms and describe its future implications in the field of dentistry.

Keywords: Dental pulp cell; Epigenetic mechanism; Epigenetics; Gene regulation; Periodontitis

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