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Vadivelu N, Kai A, Maslin B, et al. Tapentadol extended release in the management of peripheral diabetic neuropathic pain. Ther Clin Risk Manag. 2015;11:95-105doi: 10.2147/TCRM.S32193.
Vadivelu, N., Kai, A., Maslin, B., Kodumudi, G., Legler, A., & Berger, J. M. (2015). Tapentadol extended release in the management of peripheral diabetic neuropathic pain. Therapeutics and clinical risk management, 1195-105. https://doi.org/10.2147/TCRM.S32193
Vadivelu, Nalini, et al. "Tapentadol extended release in the management of peripheral diabetic neuropathic pain." Therapeutics and clinical risk management vol. 11 (2015): 95-105. doi: https://doi.org/10.2147/TCRM.S32193
Vadivelu N, Kai A, Maslin B, Kodumudi G, Legler A, Berger JM. Tapentadol extended release in the management of peripheral diabetic neuropathic pain. Ther Clin Risk Manag. 2015 Jan 14;11:95-105. doi: 10.2147/TCRM.S32193. eCollection 2015. PMID: 25609974; PMCID: PMC4298300.
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Ther Clin Risk Manag. 2015 Jan 14;11:95-105. doi: 10.2147/TCRM.S32193. eCollection 2015.

Tapentadol extended release in the management of peripheral diabetic neuropathic pain.

Therapeutics and clinical risk management

Nalini Vadivelu, Alice Kai, Benjamin Maslin, Gopal Kodumudi, Aron Legler, Jack M Berger

Affiliations

  1. Department of Anesthesiology, Yale University School of Medicine, New Haven, CT, USA.
  2. Stony Brook University School of Medicine, Stony Brook, NY, USA.
  3. Department of Structural and Cellular Biology, Tulane University, New Orleans, LA, USA.
  4. Department of Anesthesiology, Keck School of Medicine, University of Southern California, Los Angeles, CA, USA.

PMID: 25609974 PMCID: PMC4298300 DOI: 10.2147/TCRM.S32193

Abstract

Tapentadol, a μ-opioid agonist and norepinephrine reuptake inhibitor, has been found to be an effective medication for a wide variety of chronic pain conditions, including back pain, cancer-related pain, and arthritic pain. It has also been found to have fewer gastrointestinal side effects than more traditional opioid-based therapies. More recently, tapentadol extended release has been demonstrated to be effective in the management of painful diabetic neuropathy, an often debilitating condition affecting approximately one-third of all patients with diabetes. This review highlights the most up-to-date basic and clinical studies by focusing on the mechanisms of action of tapentadol and its clinical efficacy, especially with regard to painful diabetic neuropathy.

Keywords: analgesia; chronic pain; neuropathic pain; pain management; pharmacology

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