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Turkeli M, Dursun H, Albayrak F, et al. Effects of cirrhosis on bone mineral density and bone metabolism. Eurasian J Med. 2008;40(1):18-24
Turkeli, M., Dursun, H., Albayrak, F., Okçu, N., Uyanik, M. H., Uyanik, A., Yıldırım, R., Keleş, M., & Yılmaz, O. (2008). Effects of cirrhosis on bone mineral density and bone metabolism. The Eurasian journal of medicine, 40(1), 18-24.
Turkeli, Mehmet, et al. "Effects of cirrhosis on bone mineral density and bone metabolism." The Eurasian journal of medicine vol. 40,1 (2008): 18-24.
Turkeli M, Dursun H, Albayrak F, Okçu N, Uyanik MH, Uyanik A, Yıldırım R, Keleş M, Yılmaz O. Effects of cirrhosis on bone mineral density and bone metabolism. Eurasian J Med. 2008 Apr;40(1):18-24. PMID: 25610017; PMCID: PMC4261323.
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Eurasian J Med. 2008 Apr;40(1):18-24.

Effects of cirrhosis on bone mineral density and bone metabolism.

The Eurasian journal of medicine

Mehmet Turkeli, Hakan Dursun, Fatih Albayrak, Nihat Okçu, M Hamidullah Uyanik, Abdullah Uyanik, Rahşan Yıldırım, Mustafa Keleş, Omer Yılmaz

Affiliations

  1. Atatürk University, Faculty of Medicine, Department of Internal Medicine, Erzurum, Turkey.
  2. Atatürk University, Faculty of Medicine, Department of Internal Medicine, Division of Gastroenterology, Erzurum, Turkey.
  3. Atatürk University, Faculty of Medicine, Department Microbiology and Clinical Microbiology, Erzurum, Turkey.

PMID: 25610017 PMCID: PMC4261323

Abstract

OBJECTIVE: The present study was undertaken to examine the correlation between the severity of liver disease and the presence and severity of bone disease in patients with hepatic cirrhosis.

MATERIALS AND METHODS: Between January 2005 and February 2006, 40 patients with cirrhosis and 22 healthy controls were enrolled in a cross-sectional study. All subjects underwent standard laboratory testing and bone densitometric studies of the lumbar spine and femoral neck using dual X-ray absorptiometry (DEXA).

RESULTS: Cirrhotic patients had lower serum follicle-stimulating hormone (FSH) levels than controls. Male patients had lower serum free testosterone (fT) levels than male controls. 25-hydroxyvitamin D (25-OHD3) levels were significantly higher in the controls as compared to patients with cirrhosis. In the cirrhotic group, 25-OHD3 concentrations did not differ significantly between patients with Child B and C class cirrhosis. As compared to the control group, cirrhotic patients had significantly elevated levels of urinary deoxypyridinoline (DPD). The cirrhotic patients also had a significantly lower mean spinal (SD) bone mineral density (BMD) than the control group. BMD of the lumbar spine (LS) was noted to be significantly lower in the Child C group than in the Child B group. In the cirrhotic patients, there was a positive correlation between the BMD T score of the femoral neck (FN) and albumin levels whereas there was a negative correlation between BMD T scores of the FN and age, bilirubin and prothrombin time (PT).

CONCLUSION: Osteopenia and osteoporosis are highly prevalent in individuals with liver cirrhosis. Cirrhotic patients should undergo routine bone densitometric assessment and, if necessary, be treated for osteoporosis.

Keywords: Bone mineral density; Cirrhosis; Osteoporosis

References

  1. Ann Pharmacother. 1999 Feb;33(2):233-5 - PubMed
  2. Liver Transpl. 2004 May;10(5):648-53 - PubMed
  3. Hepatology. 1990 Aug;12(2):273-80 - PubMed
  4. Arq Gastroenterol. 2003 Jul-Sep;40(3):152-8 - PubMed
  5. Lancet. 1993 Mar 27;341(8848):797-801 - PubMed
  6. Gastroenterology. 1995 Jan;108(1):276-83 - PubMed
  7. J Bone Miner Res. 1998 Apr;13(4):731-8 - PubMed
  8. J Clin Endocrinol Metab. 1987 Jul;65(1):53-8 - PubMed
  9. Calcif Tissue Int. 1999 Apr;64(4):295-300 - PubMed
  10. Gut. 1990 Jan;31(1):82-7 - PubMed
  11. J Gastroenterol Hepatol. 2001 Sep;16(9):1022-7 - PubMed
  12. J Hepatol. 2005 Dec;43(6):973-83 - PubMed
  13. J Gastroenterol Hepatol. 1996 May;11(5):417-21 - PubMed
  14. Nihon Rinsho. 1998 Jun;56(6):1604-8 - PubMed
  15. Ann Intern Med. 1985 Dec;103(6 ( Pt 1)):855-60 - PubMed
  16. Hepatology. 1998 Sep;28(3):695-9 - PubMed
  17. Eur J Endocrinol. 1995 Mar;132(3):251-63 - PubMed
  18. J Clin Endocrinol Metab. 1990 Dec;71(6):1561-6 - PubMed
  19. Br J Surg. 1973 Aug;60(8):646-9 - PubMed
  20. J Hepatol. 1999 Jul;31(1):84-90 - PubMed
  21. Endocr Rev. 1996 Aug;17(4):333-68 - PubMed
  22. Hepatogastroenterology. 1997 Mar-Apr;44(14):574-81 - PubMed
  23. Yonsei Med J. 2001 Oct;42(5):547-52 - PubMed
  24. Dig Dis Sci. 1996 May;41(5):1008-13 - PubMed
  25. Gastroenterology. 1989 Jan;96(1):213-21 - PubMed
  26. JAMA. 2001 Feb 14;285(6):785-95 - PubMed
  27. Coll Relat Res. 1988 Sep;8(5):443-50 - PubMed
  28. J Clin Endocrinol Metab. 1989 Dec;69(6):1234-9 - PubMed
  29. Aliment Pharmacol Ther. 2004 Sep 1;20(5):551-7 - PubMed
  30. Med J Aust. 2001 Feb 5;174(3):150-1 - PubMed
  31. Ann Clin Lab Sci. 1991 Sep-Oct;21(5):305-14 - PubMed

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