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Ozkurt Z, Ozden K, Kiki I, et al. Prognostic significance of antithrombin activity in patients with crimean-congo hemorrhagic Fever. Eurasian J Med. 2011;43(2):83-6doi: 10.5152/eajm.2011.19.
Ozkurt, Z., Ozden, K., Kiki, I., & Usanmaz, M. (2011). Prognostic significance of antithrombin activity in patients with crimean-congo hemorrhagic Fever. The Eurasian journal of medicine, 43(2), 83-6. https://doi.org/10.5152/eajm.2011.19
Ozkurt, Zulal, et al. "Prognostic significance of antithrombin activity in patients with crimean-congo hemorrhagic Fever." The Eurasian journal of medicine vol. 43,2 (2011): 83-6. doi: https://doi.org/10.5152/eajm.2011.19
Ozkurt Z, Ozden K, Kiki I, Usanmaz M. Prognostic significance of antithrombin activity in patients with crimean-congo hemorrhagic Fever. Eurasian J Med. 2011 Aug;43(2):83-6. doi: 10.5152/eajm.2011.19. PMID: 25610169; PMCID: PMC4261357.
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Eurasian J Med. 2011 Aug;43(2):83-6. doi: 10.5152/eajm.2011.19.

Prognostic significance of antithrombin activity in patients with crimean-congo hemorrhagic Fever.

The Eurasian journal of medicine

Zulal Ozkurt, Kemalettin Ozden, Ilhami Kiki, Mustafa Usanmaz

Affiliations

  1. Department of Infectious Diseases and Clinical Microbiology, Faculty of Medicine, Ataturk University, Erzurum, Turkey.
  2. Department of Internal Medicine, Division Hematology, Faculty of Medicine, Ataturk University, Erzurum, Turkey.

PMID: 25610169 PMCID: PMC4261357 DOI: 10.5152/eajm.2011.19

Abstract

OBJECTIVE: Crimean-Congo hemorrhagic fever (CCHF) is a tick-borne viral hemorrhagic fever. Disseminated intravascular coagulation (DIC) is an important complication of this disease, especially in severe and fatal cases. Antithrombin (AT) acts as an anticoagulant by inactivating thrombin, Factor IX, Factor X and Factor XI. We conducted this study to investigate the AT levels and their prognostic value in CCHF.

MATERIALS AND METHODS: Twenty-eight confirmed CCHF patients were included in this study. Diagnosis of the disease was made by CCHF IgM and/or PCR positivity. Patients were grouped based on the severity criteria described previously. The patients with platelet counts <20 000×10(6) cell/L, white blood counts >10×10(9) cell/L, prothrombin times >60 seconds, aspartate aminotransferase levels >700 IU/L or alanine aminotransferase levels >900 IU/L were accepted as severe cases. Patients whose illnesses were self-limited and who did not require blood component replacement were accepted as mild cases, and patients who improved but required blood component replacement were accepted as moderate cases. Blood samples were obtained on the day that the patient had the lowest platelet count and before any thrombocyte replacement. The antithrombin activity was measured using a chromogenic substrate test (Diagnostica Stago STA Compact) at a research laboratory.

RESULTS: Twenty-two (78.6%) of the cases were mild, 3 (10.7%) were moderate, and 3 were (10.7%) severe. The mean AT value was 101% for mild cases, 116.6 % for moderate cases, and 88% for severe cases (p>0.05). Although there were no statistically significant differences between the AT values, the mean AT activity was lower in severe CCHF cases.

CONCLUSION: The AT activity may have been decreased in severe CCHF cases. Further studies with greater numbers of patients are required to determine the level of AT activity and its correlation with disease severity and the prognosis of CCHF.

Keywords: Antithrombin; Coagulopathy; Crimean-Congo Hemorrhagic Fever

References

  1. J Infect. 2007 Aug;55(2):184-7 - PubMed
  2. Thromb J. 2006 May 18;4:7 - PubMed
  3. Int J Antimicrob Agents. 2010 Nov;36 Suppl 1:S43-6 - PubMed
  4. Ter Arkh. 1993;65(11):22-5 - PubMed
  5. Southeast Asian J Trop Med Public Health. 1987 Sep;18(3):346-50 - PubMed
  6. Chin Med J (Engl). 1990 May;103(5):391-5 - PubMed
  7. Clin Microbiol Infect. 2006 Jun;12(6):551-4 - PubMed
  8. Thromb Haemost. 1995 Mar;73(3):368-73 - PubMed
  9. Zhonghua Shi Yan He Lin Chuang Bing Du Xue Za Zhi. 1997 Jun;11(2):163-5 - PubMed
  10. J Korean Med Sci. 1987 Dec;2(4):201-11 - PubMed
  11. Am J Hematol. 2010 Dec;85(12):947-50 - PubMed
  12. Arch Pathol Lab Med. 1997 Aug;121(8):839-46 - PubMed
  13. Am J Trop Med Hyg. 1987 Mar;36(2):416-23 - PubMed
  14. J Clin Lab Anal. 2010;24(3):163-6 - PubMed
  15. Int J Infect Dis. 2010 Aug;14(8):e704-7 - PubMed
  16. Chin Med J (Engl). 1993 Aug;106(8):608-10 - PubMed
  17. Bibl Haematol. 1983;(49):201-11 - PubMed
  18. J Infect Dis. 1999 Jul;180(1):176-86 - PubMed
  19. Thromb Haemost. 2003 Jun;89(6):967-72 - PubMed
  20. Clin Infect Dis. 2002 Aug 1;35(3):277-85 - PubMed

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