Eurasian J Med. 2014 Oct;46(3):164-8. doi: 10.5152/eajm.2014.47. Epub 2014 Aug 26.
Relation of Preoperative Thrombocytosis between Tumor Stage and Grade in Patients with Endometrial Cancer.
The Eurasian journal of medicine
Songul Kaloglu, Hakan Guraslan, Ali Ismet Tekirdag, Hediye Dagdeviren, Cihan Kaya
Affiliations
Affiliations
- Department of Obstetrics and Gynecology, Kanuni Sultan Süleyman Training and Research Hospital, Istanbul, Turkey.
- Department of Obstetrics and Gynecology, Bakirkoy Dr. Sadi Konuk Training and Research Hospital, Istanbul, Turkey.
PMID: 25610319
PMCID: PMC4299850 DOI: 10.5152/eajm.2014.47
Abstract
OBJECTIVE: We aimed to evaluate the predictive value of preoperative thrombocytosis for postoperative tumor stage and tumor grade in patients with endometrial cancer.
MATERIALS AND METHODS: This was a retrospective study carried out in our gynecologic oncology department between January 2000 and December 2011. We reviewed the medical charts of 190 patients diagnosed with endometrial carcinoma and underwent complete staging procedure. The clinicopathologic characteristics of the patients such as; age, gravidity, parity, menopausal status, body mass index, co-morbidities (diabetes, hypertension etc.), stage, grade, histological subtype, depth of myometrial invasion, peritoneal washing cytology and preoperative platelet count were recorded. Endometrioid adenocarcinomas were graded according to the FIGO classification. Blood samples for the measurement of platelet count were obtained 3 days prior to the surgery. Thrombocytosis was defined as a platelet count of 300×10(9)/L. P values less than 0.05 derived from two-tailed tests were considered statistically significant.
RESULTS: The mean age of the study population was 55.4 (range 33-80) years. The mean gravidity was 3.8 (range 0-12) and the mean parity was 3.32 (range 0-11). 108 (56,8%) patients were with body mass index of >30 kg/m(2). The mean platelet count among women was 288, 6±90.7×10(9)/L (range 105-772×10(9)/L). The majority of the patients were with early stage diseases during the surgeries. 170 (89.5%) of the patients had stage I to II disease, and 20 (10.5%) of them had stage III to IV disease. There were no statistical significance between thrombocytosis and age, gravidity, parity, BMI, cancer grade and stage, histological subtype of the tumor, depth of invasion, cervical involvement, intrauterine tumor volume and peritoneal washing cytology.
CONCLUSION: We found that preoperative platelet count was not correlated with the stage or grade of endometrial cancer.
Keywords: Endometrial cancer; prognosis; thrombocytosis
References
- Int J Gynecol Cancer. 2009 Nov;19(8):1384-9 - PubMed
- Cancer. 1995 Sep 15;76(6):998-1005 - PubMed
- Exp Ther Med. 2013 May;5(5):1351-1354 - PubMed
- Int J Gynecol Cancer. 2001 May-Jun;11(3):236-40 - PubMed
- Arch Gynecol Obstet. 2009 Jan;279(1):53-6 - PubMed
- Semin Oncol. 1994 Apr;21(2 Suppl 3):3-8 - PubMed
- CA Cancer J Clin. 1990 Jan-Feb;40(1):9-26 - PubMed
- Tumour Biol. 2000 Sep-Oct;21(5):309-14 - PubMed
- Oncologist. 1998;3(2):II - PubMed
- Gynecol Oncol. 2004 Jan;92(1):211-4 - PubMed
- J Reprod Med. 2000 Nov;45(11):929-32 - PubMed
- Ann Oncol. 1996 Oct;7(8):843-8 - PubMed
- Gynecol Oncol. 1998 Aug;70(2):210-4 - PubMed
- Blood. 2001 Nov 1;98(9):2720-5 - PubMed
- Gynecol Oncol. 2000 Aug;78(2):137-42 - PubMed
- Gynecol Oncol. 1998 Oct;71(1):29-37 - PubMed
- J Cancer Res Clin Oncol. 2009 Jan;135(1):125-9 - PubMed
- Proc Natl Acad Sci U S A. 2006 Jan 24;103(4):855-60 - PubMed
- Am J Gastroenterol. 1996 Jul;91(7):1417-22 - PubMed
- Gynecol Oncol. 2006 Dec;103(3):902-5 - PubMed
Publication Types