Display options
Cite
Saygıdeğer Demir B, Keleş T, Serindağ O. Antioxidant enzyme inhibitor role of phosphine metal complexes in lung and leukemia cell lines. Bioinorg Chem Appl. 2014;2014:717421doi: 10.1155/2014/717421.
Saygıdeğer Demir, B., Keleş, T., & Serindağ, O. (2014). Antioxidant enzyme inhibitor role of phosphine metal complexes in lung and leukemia cell lines. Bioinorganic chemistry and applications, 2014717421. https://doi.org/10.1155/2014/717421
Saygıdeğer Demir, Burcu, et al. "Antioxidant enzyme inhibitor role of phosphine metal complexes in lung and leukemia cell lines." Bioinorganic chemistry and applications vol. 2014 (2014): 717421. doi: https://doi.org/10.1155/2014/717421
Saygıdeğer Demir B, Keleş T, Serindağ O. Antioxidant enzyme inhibitor role of phosphine metal complexes in lung and leukemia cell lines. Bioinorg Chem Appl. 2014;2014:717421. doi: 10.1155/2014/717421. Epub 2014 Dec 28. PMID: 25610346; PMCID: PMC4291011.
Copy Download .nbib Format: NLM
Share it on

Bioinorg Chem Appl. 2014;2014:717421. doi: 10.1155/2014/717421. Epub 2014 Dec 28.

Antioxidant enzyme inhibitor role of phosphine metal complexes in lung and leukemia cell lines.

Bioinorganic chemistry and applications

Burcu Saygıdeğer Demir, Tuğba Keleş, Osman Serindağ

Affiliations

  1. Department of Chemistry, Science, and Letters Faculty, Osmaniye Korkut Ata University, Fak?u?a??, 80000 Osmaniye, Turkey.
  2. Department of Chemistry and Chemical Technology, University of Bayburt, 69000 Bayburt, Turkey.
  3. Science Institute, Kanuni University, 01170 Adana, Turkey.

PMID: 25610346 PMCID: PMC4291011 DOI: 10.1155/2014/717421

Abstract

Phosphine metal complexes have been recently evaluated in the field of cancer therapy. In this research, the cytotoxic effects of some metal phosphines {[PdCl2((CH2OH)2PCH2)2NCH3] (C1), [RuCl2(((CH2OH)2PCH2)2NCH3)2] (C2), [PtCl2((Ph2PCH2)2NCH3)(timin)2] (C3)} on K562 (human myelogenous leukemia cell line) and A549 (adenocarcinomic human alveolar basal epithelial cells) cells were investigated using the MTT test. C1 and C2 are water-soluble metal complexes, which may have some advantages in in vitro and in vivo studies. The effects of the above-mentioned metal complexes on thioredoxin reductase (TrxR) (EC: 1.8.1.9), glutathione peroxidase (GPx) (EC: 1.11.1.9), and catalase (Cat) (EC: 1.11.1.6) enzymes were also tested. The results of this research showed that all three metal complexes indicated dose-dependent cytotoxicity on A549 and K562 cell lines and that the complexes inhibited different percentages of the TrxR, GPx, and Cat enzymes of these tumor cells.

References

  1. Cancer Res. 1985 Jan;45(1):32-9 - PubMed
  2. Eur J Biochem. 2000 Oct;267(20):6110-7 - PubMed
  3. J Inorg Biochem. 2013 Jul;124:78-87 - PubMed
  4. Biochem Pharmacol. 2010 Jan 15;79(2):90-101 - PubMed
  5. Biochem Pharmacol. 2010 Feb 1;79(3):350-60 - PubMed
  6. Free Radic Biol Med. 1999 Dec;27(11-12):1334-45 - PubMed
  7. J Biol Chem. 2001 Jan 5;276(1):514-21 - PubMed
  8. Curr Opin Chem Biol. 2008 Apr;12(2):197-206 - PubMed
  9. J Biol Chem. 1998 Aug 7;273(32):20096-101 - PubMed
  10. Biochem J. 1998 Jun 1;332 ( Pt 2):591-2 - PubMed
  11. Eur J Med Chem. 2011 Oct;46(10 ):5099-107 - PubMed
  12. Inorg Chem. 2009 Aug 3;48(15):7413-20 - PubMed
  13. Biochimie. 2012 Feb;94(2):345-53 - PubMed
  14. Arch Immunol Ther Exp (Warsz). 2001;49(4):285-92 - PubMed
  15. J Inorg Biochem. 2011 Feb;105(2):232-40 - PubMed
  16. J Biol Chem. 2009 Sep 4;284(36):24306-19 - PubMed
  17. Science. 1966 Jan 14;151(3707):172-7 - PubMed
  18. J Med Chem. 2009 Dec 10;52(23):7753-64 - PubMed
  19. Cancer Lett. 2007 Jul 8;252(1):1-8 - PubMed
  20. Spectrochim Acta A Mol Biomol Spectrosc. 2004 Nov;60(13):3087-92 - PubMed
  21. Cancer Lett. 2006 May 8;236(1):46-53 - PubMed
  22. Cancer Res. 2009 Jul 1;69(13):5458-66 - PubMed
  23. Proc Natl Acad Sci U S A. 2005 Sep 20;102(38):13604-9 - PubMed
  24. Biochem Pharmacol. 2007 Oct 1;74(7):992-1002 - PubMed
  25. Free Radic Biol Med. 2012 Jan 15;52(2):436-43 - PubMed
  26. Eur J Biochem. 2000 Oct;267(20):6118-25 - PubMed
  27. Dalton Trans. 2011 Sep 28;40(36):9212-20 - PubMed
  28. ChemMedChem. 2010 Jan;5(1):96-102 - PubMed
  29. J Med Chem. 2001 Aug 16;44(17):2784-92 - PubMed
  30. Free Radic Biol Med. 2007 Mar 15;42(6):872-81 - PubMed
  31. J Mol Biol. 2000 Feb 11;296(1):295-309 - PubMed
  32. Inorg Chem. 2003 Aug 11;42(16):4938-48 - PubMed
  33. Biochem J. 2000 Feb 15;346 Pt 1:1-8 - PubMed
  34. Biochem Pharmacol. 2006 Feb 14;71(4):408-15 - PubMed
  35. Free Radic Biol Med. 2005 Sep 1;39(5):696-703 - PubMed
  36. Dalton Trans. 2009 Dec 28;(48):10882-8 - PubMed
  37. J Biol Chem. 1951 Nov;193(1):265-75 - PubMed
  38. Chembiochem. 2009 Jul 20;10(11):1796-800 - PubMed
  39. J Med Chem. 2007 Nov 29;50(24):5871-4 - PubMed
  40. Free Radic Biol Med. 2001 Dec 1;31(11):1287-312 - PubMed
  41. Blood. 2005 Feb 1;105(3):1265-73 - PubMed
  42. Biochem Pharmacol. 2004 Mar 15;67(6):1139-51 - PubMed
  43. Semin Cancer Biol. 2006 Dec;16(6):452-65 - PubMed
  44. J Biol Chem. 2000 Jun 16;275(24):18121-8 - PubMed

Publication Types