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Obien ME, Deligkaris K, Bullmann T, et al. Revealing neuronal function through microelectrode array recordings. Front Neurosci. 2015;8:423doi: 10.3389/fnins.2014.00423.
Obien, M. E., Deligkaris, K., Bullmann, T., Bakkum, D. J., & Frey, U. (2014). Revealing neuronal function through microelectrode array recordings. Frontiers in neuroscience, 8423. https://doi.org/10.3389/fnins.2014.00423
Obien, Marie Engelene J, et al. "Revealing neuronal function through microelectrode array recordings." Frontiers in neuroscience vol. 8 (2014): 423. doi: https://doi.org/10.3389/fnins.2014.00423
Obien ME, Deligkaris K, Bullmann T, Bakkum DJ, Frey U. Revealing neuronal function through microelectrode array recordings. Front Neurosci. 2015 Jan 06;8:423. doi: 10.3389/fnins.2014.00423. eCollection 2014. PMID: 25610364; PMCID: PMC4285113.
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Front Neurosci. 2015 Jan 06;8:423. doi: 10.3389/fnins.2014.00423. eCollection 2014.

Revealing neuronal function through microelectrode array recordings.

Frontiers in neuroscience

Marie Engelene J Obien, Kosmas Deligkaris, Torsten Bullmann, Douglas J Bakkum, Urs Frey

Affiliations

  1. RIKEN Quantitative Biology Center, RIKEN Kobe, Japan.
  2. RIKEN Quantitative Biology Center, RIKEN Kobe, Japan ; Graduate School of Frontier Biosciences, Osaka University Osaka, Japan.
  3. Department of Biosystems Science and Engineering, ETH Zurich Basel, Switzerland.
  4. RIKEN Quantitative Biology Center, RIKEN Kobe, Japan ; Graduate School of Frontier Biosciences, Osaka University Osaka, Japan ; Department of Biosystems Science and Engineering, ETH Zurich Basel, Switzerland.

PMID: 25610364 PMCID: PMC4285113 DOI: 10.3389/fnins.2014.00423

Abstract

Microelectrode arrays and microprobes have been widely utilized to measure neuronal activity, both in vitro and in vivo. The key advantage is the capability to record and stimulate neurons at multiple sites simultaneously. However, unlike the single-cell or single-channel resolution of intracellular recording, microelectrodes detect signals from all possible sources around every sensor. Here, we review the current understanding of microelectrode signals and the techniques for analyzing them. We introduce the ongoing advancements in microelectrode technology, with focus on achieving higher resolution and quality of recordings by means of monolithic integration with on-chip circuitry. We show how recent advanced microelectrode array measurement methods facilitate the understanding of single neurons as well as network function.

Keywords: CMOS; extracellular recording; microelectrode array; multi-scale modeling; multielectrode array; neuron-electrode interface; neuronal function; stimulation

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