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Omari TI, Wiklendt L, Dinning P, et al. Upper esophageal sphincter mechanical states analysis: a novel methodology to describe UES relaxation and opening. Front Syst Neurosci. 2015;8:241doi: 10.3389/fnsys.2014.00241.
Omari, T. I., Wiklendt, L., Dinning, P., Costa, M., Rommel, N., & Cock, C. (2014). Upper esophageal sphincter mechanical states analysis: a novel methodology to describe UES relaxation and opening. Frontiers in systems neuroscience, 8241. https://doi.org/10.3389/fnsys.2014.00241
Omari, Taher I, et al. "Upper esophageal sphincter mechanical states analysis: a novel methodology to describe UES relaxation and opening." Frontiers in systems neuroscience vol. 8 (2014): 241. doi: https://doi.org/10.3389/fnsys.2014.00241
Omari TI, Wiklendt L, Dinning P, Costa M, Rommel N, Cock C. Upper esophageal sphincter mechanical states analysis: a novel methodology to describe UES relaxation and opening. Front Syst Neurosci. 2015 Jan 07;8:241. doi: 10.3389/fnsys.2014.00241. eCollection 2014. PMID: 25610376; PMCID: PMC4285690.
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Front Syst Neurosci. 2015 Jan 07;8:241. doi: 10.3389/fnsys.2014.00241. eCollection 2014.

Upper esophageal sphincter mechanical states analysis: a novel methodology to describe UES relaxation and opening.

Frontiers in systems neuroscience

Taher I Omari, Lukasz Wiklendt, Philip Dinning, Marcello Costa, Nathalie Rommel, Charles Cock

Affiliations

  1. Department of Human Physiology, School of Medicine, Flinders University Adelaide, SA, Australia ; Department of Gastroenterology and Hepatology, Flinders Medical Centre and School of Medicine, Flinders University Adelaide, SA, Australia.
  2. Department of Human Physiology, School of Medicine, Flinders University Adelaide, SA, Australia.
  3. Translational Research Center for Gastrointestinal Diseases, University of Leuven Leuven, Belgium.
  4. Department of Gastroenterology and Hepatology, Flinders Medical Centre and School of Medicine, Flinders University Adelaide, SA, Australia.

PMID: 25610376 PMCID: PMC4285690 DOI: 10.3389/fnsys.2014.00241

Abstract

The swallowing muscles that influence upper esophageal sphincter (UES) opening are centrally controlled and modulated by sensory information. Activation of neural inputs to these muscles, the intrinsic cricopharyngeus muscle and extrinsic suprahyoid muscles, results in their contraction or relaxation, which changes the diameter of the lumen, alters the intraluminal pressure and ultimately inhibits or promotes flow of content. This relationship that exists between the changes in diameter and concurrent changes in intraluminal pressure has been used previously to calculate the "mechanical states" of the muscle; that is when the muscles are passively or actively, relaxing or contracting. Diseases that alter the neural pathways to these muscles can result in weakening the muscle contractility and/or decreasing the muscle compliance, all of which can cause dysphagia. Detecting these changes in the mechanical state of the muscle is difficult and as the current interpretation of UES motility is based largely upon pressure measurement (manometry), subtle changes in the muscle function during swallow can be missed. We hypothesized that quantification of mechanical states of the UES and the pressure-diameter properties that define them, would allow objective characterization of the mechanisms that govern the timing and extent of UES opening during swallowing. To achieve this we initially analyzed swallows captured by simultaneous videofluoroscopy and UES pressure with impedance recording. From these data we demonstrated that intraluminal impedance measurements could be used to determine changes in the internal diameter of the lumen when compared to videofluoroscopy. Then using a database of pressure-impedance studies, recorded from young and aged healthy controls and patients with motor neuron disease, we calculated the UES mechanical states in relation to a standardized swallowed bolus volume, normal aging and dysphagia pathology. Our results indicated that eight different mechanical states were almost always seen during healthy swallowing and some of these calculated changes in muscle function were consistent with the known neurally dependent phasic discharge patterns of cricopharyngeus muscle activity during swallowing. Clearly defined changes in the mechanical states were observed in motor neuron disease when compared to age matched healthy controls. Our data indicate that mechanical state predictions were simple to apply and revealed patterns consistent with the known neural inputs activating the different muscles during swallowing.

Keywords: cricopharyngeus muscle; dysphagia; impedance; neural pathways; pressure; suprahyoid muscles; swallow; upper esophageal sphincter

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