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Lipatova Z, Segev N. Ypt/Rab GTPases regulate two intersections of the secretory and the endosomal/lysosomal pathways. Cell Logist. 2014;4(3):e954870doi: 10.4161/21592780.2014.954870.
Lipatova, Z., & Segev, N. (2014). Ypt/Rab GTPases regulate two intersections of the secretory and the endosomal/lysosomal pathways. Cellular logistics, 4(3), e954870. https://doi.org/10.4161/21592780.2014.954870
Lipatova, Zhanna, and Segev, Nava. "Ypt/Rab GTPases regulate two intersections of the secretory and the endosomal/lysosomal pathways." Cellular logistics vol. 4,3 (2014): e954870. doi: https://doi.org/10.4161/21592780.2014.954870
Lipatova Z, Segev N. Ypt/Rab GTPases regulate two intersections of the secretory and the endosomal/lysosomal pathways. Cell Logist. 2014 Jul 03;4(3):e954870. doi: 10.4161/21592780.2014.954870. eCollection 2014. PMID: 25610722; PMCID: PMC4279804.
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Cell Logist. 2014 Jul 03;4(3):e954870. doi: 10.4161/21592780.2014.954870. eCollection 2014.

Ypt/Rab GTPases regulate two intersections of the secretory and the endosomal/lysosomal pathways.

Cellular logistics

Zhanna Lipatova, Nava Segev

Affiliations

  1. Department of Biochemistry and Molecular Genetics; University of Illinois at Chicago ; Chicago, IL USA.

PMID: 25610722 PMCID: PMC4279804 DOI: 10.4161/21592780.2014.954870

Abstract

A prevailing question in the Ypt/Rab field is whether these conserved GTPases are specific to cellular compartments. The established role for Ypt1 and its human homolog Rab1 is in endoplasmic reticulum (ER)-to-Golgi transport. More recently these regulators were implicated also in autophagy. Two different TRAPP complexes, I and III, were identified as the guanine-nucleotide-exchange factors (GEFs) of Ypt1 in ER-to-Golgi transport and autophagy, respectively. Confusingly, Ypt1 and TRAPP III were also suggested to regulate endosome-to-Golgi transport, implying that they function at multiple cellular compartments, and bringing into question the nature of Ypt/Rab specificity. Recently, we showed that the role of TRAPP III and Ypt1 in autophagy occurs at the ER and that they do not regulate endosome-to-Golgi transport. Here, we discuss the significance of this conclusion to the idea that Ypt/Rabs are specific to cellular compartments. We postulate that Ypt1 regulates 2 alternative routes emanating from the ER toward the Golgi and the lysosome/vacuole. We further propose that the secretory and endocytic/lysosomal pathways intersect in 2 junctures, and 2 Ypts, Ypt1 and Ypt31, coordinate transport in the 2 intersections: Ypt1 links ER-to-Golgi and ER-to-autophagy transport, whereas Ypt31 links Golgi-to-plasma membrane (PM) transport with PM-to-Golgi recycling through endosomes.

Keywords: ER-phagy; GTPase; Rab; TRAPP; Ypt1; Ypt31; cellular recycling; endosome-to-Golgi transport; secretory pathway

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