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Greenman R, Gorelik A, Sapir T, et al. Non-cell autonomous and non-catalytic activities of ATX in the developing brain. Front Neurosci. 2015;9:53doi: 10.3389/fnins.2015.00053.
Greenman, R., Gorelik, A., Sapir, T., Baumgart, J., Zamor, V., Segal-Salto, M., Levin-Zaidman, S., Aidinis, V., Aoki, J., Nitsch, R., Vogt, J., & Reiner, O. (2015). Non-cell autonomous and non-catalytic activities of ATX in the developing brain. Frontiers in neuroscience, 953. https://doi.org/10.3389/fnins.2015.00053
Greenman, Raanan, et al. "Non-cell autonomous and non-catalytic activities of ATX in the developing brain." Frontiers in neuroscience vol. 9 (2015): 53. doi: https://doi.org/10.3389/fnins.2015.00053
Greenman R, Gorelik A, Sapir T, Baumgart J, Zamor V, Segal-Salto M, Levin-Zaidman S, Aidinis V, Aoki J, Nitsch R, Vogt J, Reiner O. Non-cell autonomous and non-catalytic activities of ATX in the developing brain. Front Neurosci. 2015 Mar 04;9:53. doi: 10.3389/fnins.2015.00053. eCollection 2015. PMID: 25788872; PMCID: PMC4349085.
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Front Neurosci. 2015 Mar 04;9:53. doi: 10.3389/fnins.2015.00053. eCollection 2015.

Non-cell autonomous and non-catalytic activities of ATX in the developing brain.

Frontiers in neuroscience

Raanan Greenman, Anna Gorelik, Tamar Sapir, Jan Baumgart, Vanessa Zamor, Michal Segal-Salto, Smadar Levin-Zaidman, Vassilis Aidinis, Junken Aoki, Robert Nitsch, Johannes Vogt, Orly Reiner

Affiliations

  1. Department of Molecular Genetics, Weizmann Institute of Science Rehovot, Israel.
  2. University Medical Center, Institute for Microscopic Anatomy and Neurobiology, Johannes Gutenberg-University Mainz Mainz, Germany ; Central Laboratory Animal Facility, University Medical Center, Johannes Gutenberg-University Mainz Mainz, Germany.
  3. Department of Chemical Research Support, Weizmann Institute of Science Rehovot, Israel.
  4. Division of Immunology, Biomedical Sciences Research Center 'Alexander Fleming' Athens, Greece.
  5. Graduate School of Pharmaceutical Sciences, Tohoku University Miyagi, Japan.
  6. University Medical Center, Institute for Microscopic Anatomy and Neurobiology, Johannes Gutenberg-University Mainz Mainz, Germany.

PMID: 25788872 PMCID: PMC4349085 DOI: 10.3389/fnins.2015.00053

Abstract

The intricate formation of the cerebral cortex requires a well-coordinated series of events, which are regulated at the level of cell-autonomous and non-cell autonomous mechanisms. Whereas cell-autonomous mechanisms that regulate cortical development are well-studied, the non-cell autonomous mechanisms remain poorly understood. A non-biased screen allowed us to identify Autotaxin (ATX) as a non-cell autonomous regulator of neural stem cells. ATX (also known as ENPP2) is best known to catalyze lysophosphatidic acid (LPA) production. Our results demonstrate that ATX affects the localization and adhesion of neuronal progenitors in a cell autonomous and non-cell autonomous manner, and strikingly, this activity is independent from its catalytic activity in producing LPA.

Keywords: LPA; autotaxin; cortical development; in utero electroporation; neuronal stem cell; radial glia

References

  1. Purinergic Signal. 2012 Jun;8(2):181-90 - PubMed
  2. Cell. 2008 Feb 8;132(3):487-98 - PubMed
  3. Nature. 1993 Aug 19;364(6439):717-21 - PubMed
  4. J Neurosci. 2008 May 28;28(22):5710-20 - PubMed
  5. Cell Mol Life Sci. 2007 Jan;64(2):230-43 - PubMed
  6. Dev Cell. 2010 Mar 16;18(3):472-9 - PubMed
  7. J Cell Sci. 2005 Jul 15;118(Pt 14):3081-9 - PubMed
  8. J Proteome Res. 2007 Sep;6(9):3537-48 - PubMed
  9. Hum Mol Genet. 2012 Apr 15;21(8):1681-92 - PubMed
  10. BMC Neurosci. 2008 Dec 11;9:118 - PubMed
  11. J Biol Chem. 2007 Apr 13;282(15):11084-91 - PubMed
  12. Stem Cells. 2008 May;26(5):1146-54 - PubMed
  13. J Neurochem. 1998 Jan;70(1):66-76 - PubMed
  14. Neuron. 1999 Jun;23(2):257-71 - PubMed
  15. Biochimie. 2010 Jun;92 (6):698-706 - PubMed
  16. Nat Neurosci. 2011 Jun;14(6):697-703 - PubMed
  17. Mol Pain. 2008 Apr 01;4:11 - PubMed
  18. Mult Scler. 2004 Jun;10(3):245-60 - PubMed
  19. Cell. 2007 May 4;129(3):579-91 - PubMed
  20. Sheng Li Xue Bao. 2007 Dec 25;59(6):759-64 - PubMed
  21. J Biol Chem. 2011 Oct 7;286(40):34654-63 - PubMed
  22. J Biol Chem. 2008 Mar 21;283(12 ):7470-9 - PubMed
  23. J Mol Neurosci. 2012 Mar;46(3):516-26 - PubMed
  24. Mech Dev. 2003 Sep;120(9):1033-43 - PubMed
  25. Nat Struct Mol Biol. 2011 Feb;18(2):198-204 - PubMed
  26. Science. 2006 Mar 17;311(5767):1609-12 - PubMed
  27. Ann N Y Acad Sci. 2000 Apr;905:132-41 - PubMed
  28. Mol Pain. 2008 Feb 08;4:6 - PubMed
  29. J Neurosci. 2003 Sep 24;23 (25):8673-81 - PubMed
  30. Neuroscience. 2004;129(2):371-80 - PubMed
  31. Sheng Li Xue Bao. 2006 Dec 25;58(6):547-55 - PubMed
  32. J Neural Transm (Vienna). 2002 May;109 (5-6):623-31 - PubMed
  33. J Cell Biochem. 2004 Aug 1;92 (5):993-1003 - PubMed
  34. Cereb Cortex. 2006 Sep;16(9):1323-31 - PubMed
  35. Biochem Biophys Res Commun. 1992 May 29;185(1):350-5 - PubMed
  36. Nat Neurosci. 2006 Sep;9(9):1099-107 - PubMed
  37. Cell. 1998 Jan 9;92(1):51-61 - PubMed
  38. J Biochem. 2012 Jan;151(1):89-97 - PubMed
  39. Cereb Cortex. 2008 Apr;18(4):938-50 - PubMed
  40. Nat Cell Biol. 2000 Nov;2(11):767-75 - PubMed
  41. Neuron. 2004 Jan 22;41(2):215-27 - PubMed
  42. Novartis Found Symp. 2007;288:45-53; discussion 53-8, 96-8 - PubMed
  43. Dev Cell. 2012 Jul 17;23(1):181-92 - PubMed
  44. Neurosci Lett. 2010 Aug 16;480(2):154-7 - PubMed
  45. Neuron. 2006 Jan 5;49(1):55-66 - PubMed
  46. Nat Commun. 2013;4:2033 - PubMed
  47. Nat Neurosci. 2003 Dec;6(12):1292-9 - PubMed
  48. Biochem Biophys Res Commun. 2006 May 12;343(3):839-47 - PubMed
  49. EMBO J. 2004 Feb 25;23 (4):823-32 - PubMed
  50. Nat Struct Biol. 2003 May;10(5):324-33 - PubMed
  51. Science. 2002 Jun 7;296(5574):1855-7 - PubMed
  52. Dev Biol. 2005 Jul 15;283(2):269-81 - PubMed
  53. J Biol Chem. 1992 Feb 5;267(4):2524-9 - PubMed
  54. Dev Dyn. 2007 Apr;236(4):1134-43 - PubMed
  55. Stem Cells Dev. 2004 Dec;13(6):685-93 - PubMed
  56. Neuron. 2000 Dec;28(3):697-711 - PubMed
  57. Curr Opin Neurobiol. 2010 Feb;20(1):68-78 - PubMed
  58. Hum Mol Genet. 2000 Sep 22;9(15):2205-13 - PubMed
  59. Scientifica (Cairo). 2013;2013:393975 - PubMed
  60. Trends Genet. 2009 Dec;25(12):555-66 - PubMed
  61. Neuron. 2000 Dec;28(3):681-96 - PubMed
  62. J Biol Chem. 2002 Oct 18;277(42):39436-42 - PubMed
  63. Neuron. 2010 Nov 18;68(4):695-709 - PubMed
  64. Neuron. 2009 Jul 30;63(2):189-202 - PubMed
  65. J Cell Biol. 2002 Jul 22;158(2):227-33 - PubMed
  66. Development. 2008 Jan;135(1):11-22 - PubMed
  67. J Lipid Res. 2013 May;54(5):1192-206 - PubMed
  68. Neurosci Lett. 2006 May 29;400(1-2):97-100 - PubMed
  69. Mol Cell. 2012 Sep 14;47(5):707-21 - PubMed
  70. Nat Med. 2004 Jul;10(7):712-8 - PubMed
  71. Virology. 1973 Aug;54(2):536-9 - PubMed
  72. Mol Cell Neurosci. 2008 Feb;37(2):412-24 - PubMed
  73. Cell Mol Neurobiol. 2008 Dec;28(8):1109-18 - PubMed
  74. Neuron. 2010 Aug 26;67(4):588-602 - PubMed
  75. Nat Neurosci. 2003 Dec;6(12):1277-83 - PubMed
  76. Int J Dev Biol. 2009;53(1):139-47 - PubMed
  77. Mol Cell Neurosci. 2004 Oct;27(2):140-50 - PubMed
  78. Cell. 1998 Jan 9;92(1):63-72 - PubMed
  79. Dev Biol. 2010 Mar 15;339(2):451-64 - PubMed
  80. J Neurochem. 2005 Feb;92 (4):904-14 - PubMed
  81. Mol Cell Biol. 2006 Jul;26(13):5015-22 - PubMed
  82. J Neurochem. 2003 Dec;87(5):1272-83 - PubMed
  83. Neuron. 2004 Jan 22;41(2):203-13 - PubMed
  84. FEBS Lett. 2004 Jul 30;571(1-3):197-204 - PubMed
  85. Trends Biochem Sci. 2005 Oct;30(10):542-50 - PubMed
  86. Genesis. 2007 Jul;45(7):465-9 - PubMed
  87. J Biol Chem. 2006 Sep 1;281(35):25822-30 - PubMed
  88. Curr Opin Neurobiol. 2013 Dec;23(6):951-6 - PubMed
  89. Nat Cell Biol. 2000 Nov;2(11):784-91 - PubMed
  90. Neurochem Int. 2007 Jan;50(2):302-7 - PubMed
  91. Dev Biol. 2009 Apr 1;328(1):66-77 - PubMed
  92. Sheng Li Xue Bao. 2005 Jun 25;57(3):289-94 - PubMed
  93. Cell. 2007 Jan 12;128(1):29-43 - PubMed
  94. Biochem J. 2011 Oct 1;439(1):45-55 - PubMed

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