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Torres KJ, Reyes-Terán G, Sotelo J, et al. Influence of quinacrine and chloroquine on the in vitro 3'-azido-3'-deoxythymidine antiretroviral effect. AIDS Res Ther. 2015;12:7doi: 10.1186/s12981-015-0048-9.
Torres, K. J., Reyes-Terán, G., Sotelo, J., Jung-Cook, H., & Aguirre-Cruz, L. (2015). Influence of quinacrine and chloroquine on the in vitro 3'-azido-3'-deoxythymidine antiretroviral effect. AIDS research and therapy, 127. https://doi.org/10.1186/s12981-015-0048-9
Torres, Klintsy J, et al. "Influence of quinacrine and chloroquine on the in vitro 3'-azido-3'-deoxythymidine antiretroviral effect." AIDS research and therapy vol. 12 (2015): 7. doi: https://doi.org/10.1186/s12981-015-0048-9
Torres KJ, Reyes-Terán G, Sotelo J, Jung-Cook H, Aguirre-Cruz L. Influence of quinacrine and chloroquine on the in vitro 3'-azido-3'-deoxythymidine antiretroviral effect. AIDS Res Ther. 2015 Mar 19;12:7. doi: 10.1186/s12981-015-0048-9. eCollection 2015. PMID: 25788967; PMCID: PMC4364635.
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AIDS Res Ther. 2015 Mar 19;12:7. doi: 10.1186/s12981-015-0048-9. eCollection 2015.

Influence of quinacrine and chloroquine on the in vitro 3'-azido-3'-deoxythymidine antiretroviral effect.

AIDS research and therapy

Klintsy J Torres, Gustavo Reyes-Terán, Julio Sotelo, Helgi Jung-Cook, Lucinda Aguirre-Cruz

Affiliations

  1. Laboratorio de Neuroimmunoendocrinología, Instituto Nacional de Neurología y Neurocirugía Manuel Velasco Suárez, Av. Insurgentes Sur 3877, 14269 México D F, México ; Centro de Investigación en Enfermedades Infecciosas, Instituto Nacional de Enfermedades Respiratorias Ismael Cosío Villegas, Calzada de Tlalpan 4502, Col. Sección XVI, 14080 México D F, México.
  2. Centro de Investigación en Enfermedades Infecciosas, Instituto Nacional de Enfermedades Respiratorias Ismael Cosío Villegas, Calzada de Tlalpan 4502, Col. Sección XVI, 14080 México D F, México.
  3. Laboratorio de Neuroinmunología y, ?, ? ?, ?
  4. Laboratorio de Neuropsicofarmacología, Av. Insurgentes Sur 3877, Col. La Fama-Tlalpan, 14269 México D F, México ; Departamento de Farmacia, Facultad de Química, Universidad Nacional Autónoma de México, Circuito Interior, Ciudad Universitaria, Col. Copilco, 04510 México D F, México.
  5. Laboratorio de Neuroimmunoendocrinología, Instituto Nacional de Neurología y Neurocirugía Manuel Velasco Suárez, Av. Insurgentes Sur 3877, 14269 México D F, México ; Laboratorio de Neuroinmunología y, ?, ? ?, ?

PMID: 25788967 PMCID: PMC4364635 DOI: 10.1186/s12981-015-0048-9

Abstract

BACKGROUND: Antimalarials quinacrine (Qc) and chloroquine (Cq) intercalate DNA, potentiate the activity of other drugs and have lysosomotropic, anti-inflammatory and antiviral activities that could increase the effect of the 3'-azido-3'-deoxythymidine (AZT) antiretroviral agent. The aim of the current study was to evaluate if Qc and Cq could improve the in vitro effect of the antiretroviral AZT agent.

FINDINGS: Inhibition of viral replication in human immunodeficiency virus (HIV)SF33-infected peripheral blood mononuclear cells treated with Qc or Cq, alone or combined with a low dose of AZT was measured. Viral replication increased with Qc and decreased with high doses of Cq. The increase of replication caused by Qc was reversed by AZT. Neither Qc nor Cq significantly changed the antiviral activity of AZT.

CONCLUSION: Cq does not potentiate the effect of AZT, but it is effective by itself at high doses. The rise of HIV replication by Qc could be deleterious in HIV endemic regions, where it is used as antimalarial. The mechanisms associated to this phenomenon must be identified.

Keywords: AZT; Antimalarials; Chloroquine; HIV; Quinacrine

References

  1. Biochim Biophys Acta. 1982 Oct 14;713(1):112-7 - PubMed
  2. J Clin Virol. 2001 Feb;20(3):131-5 - PubMed
  3. AIDS. 2001 Nov 9;15(16):2205-7 - PubMed
  4. AIDS Res Hum Retroviruses. 2006 Feb;22(2):144-52 - PubMed
  5. AIDS Res Hum Retroviruses. 2010 Mar;26(3):339-42 - PubMed
  6. PLoS One. 2012;7(12):e51387 - PubMed
  7. J Biomol Struct Dyn. 2000 Dec;18(3):371-83 - PubMed
  8. J Immunol Methods. 1985 Jan 21;76(1):171-83 - PubMed
  9. Blood. 2011 Sep 22;118(12):3263-72 - PubMed
  10. Lancet Infect Dis. 2011 Sep;11(9):653-4 - PubMed
  11. PLoS One. 2013 Dec 31;8(12):e83682 - PubMed
  12. Blood. 2000 Jun 1;95(11):3460-6 - PubMed
  13. Antimicrob Agents Chemother. 2014;58(1):584-6 - PubMed
  14. Proc Natl Acad Sci U S A. 1965 Aug;54(2):521-7 - PubMed
  15. AIDS. 2001 Nov 23;15(17):2221-9 - PubMed
  16. Afr Health Sci. 2003 Aug;3(2):61-7 - PubMed
  17. Drugs. 2012 Jun 18;72(9):e1-25 - PubMed
  18. J Acquir Immune Defic Syndr. 2007 Jun 1;45 Suppl 1:S14-8 - PubMed
  19. Eur J Immunol. 2007 Aug;37(8):2257-67 - PubMed
  20. Antimicrob Agents Chemother. 2010 Feb;54(2):871-81 - PubMed
  21. J Cancer Res Clin Oncol. 1991;117(1):19-26 - PubMed
  22. APMIS. 2012 Jul;120(7):597-604 - PubMed
  23. J Clin Invest. 1997 Aug 15;100(4):921-30 - PubMed
  24. Br J Rheumatol. 1997 Jul;36(7):799-805 - PubMed
  25. AIDS Res Treat. 2011;2011:749041 - PubMed

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