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Bowler M, Nethercott DR. Two lessons from the empiric management of a combined overdose of liraglutide and amitriptyline. A A Case Rep. 2014;2(3):28-30doi: 10.1097/ACC.0b013e3182a526fa.
Bowler, M., & Nethercott, D. R. (2014). Two lessons from the empiric management of a combined overdose of liraglutide and amitriptyline. A & A case reports, 2(3), 28-30. https://doi.org/10.1097/ACC.0b013e3182a526fa
Bowler, Matthew, and Nethercott, Daniel Robert. "Two lessons from the empiric management of a combined overdose of liraglutide and amitriptyline." A & A case reports vol. 2,3 (2014): 28-30. doi: https://doi.org/10.1097/ACC.0b013e3182a526fa
Bowler M, Nethercott DR. Two lessons from the empiric management of a combined overdose of liraglutide and amitriptyline. A A Case Rep. 2014 Feb 01;2(3):28-30. doi: 10.1097/ACC.0b013e3182a526fa. PMID: 25611153.
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A A Case Rep. 2014 Feb 01;2(3):28-30. doi: 10.1097/ACC.0b013e3182a526fa.

Two lessons from the empiric management of a combined overdose of liraglutide and amitriptyline.

A & A case reports

Matthew Bowler, Daniel Robert Nethercott

Affiliations

  1. From the Department of Anaesthetics, North West School of Anaesthesia, Manchester; and Anaesthesia and Critical Care Medicine, Royal Bolton Hospital, Bolton, United Kingdom.

PMID: 25611153 DOI: 10.1097/ACC.0b013e3182a526fa

Abstract

We report the case of a 52-year-old man with a combined liraglutide and amitriptyline overdose who presented with a seizure and then pulseless electrical activity cardiac arrest. This is the largest reported overdose of liraglutide (36 mg), a novel glucagon-like peptide-1 analog recommended for certain patients with type 2 diabetes mellitus. The subsequent biochemical effects included severe electrolyte disturbances associated with polyuria. Regarding the amitriptyline, treatment with lipid emulsion correlated with resolution of electrocardiographic changes and successful resuscitation. The treatment of amitriptyline overdose with lipid emulsion is briefly discussed.

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