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Okita Y, Nonaka M, Umehara T, et al. Efficacy of temozolomide and bevacizumab for the treatment of leptomeningeal dissemination of recurrent glioblastoma: A case report. Oncol Lett. 2015;9(4):1885-1888doi: 10.3892/ol.2015.2940.
Okita, Y., Nonaka, M., Umehara, T., Kanemura, Y., Kodama, Y., Mano, M., & Nakajima, S. (2015). Efficacy of temozolomide and bevacizumab for the treatment of leptomeningeal dissemination of recurrent glioblastoma: A case report. Oncology letters, 9(4), 1885-1888. https://doi.org/10.3892/ol.2015.2940
Okita, Yoshiko, et al. "Efficacy of temozolomide and bevacizumab for the treatment of leptomeningeal dissemination of recurrent glioblastoma: A case report." Oncology letters vol. 9,4 (2015): 1885-1888. doi: https://doi.org/10.3892/ol.2015.2940
Okita Y, Nonaka M, Umehara T, Kanemura Y, Kodama Y, Mano M, Nakajima S. Efficacy of temozolomide and bevacizumab for the treatment of leptomeningeal dissemination of recurrent glioblastoma: A case report. Oncol Lett. 2015 Apr;9(4):1885-1888. doi: 10.3892/ol.2015.2940. Epub 2015 Feb 06. PMID: 25789061; PMCID: PMC4356381.
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Oncol Lett. 2015 Apr;9(4):1885-1888. doi: 10.3892/ol.2015.2940. Epub 2015 Feb 06.

Efficacy of temozolomide and bevacizumab for the treatment of leptomeningeal dissemination of recurrent glioblastoma: A case report.

Oncology letters

Yoshiko Okita, Masahiro Nonaka, Toru Umehara, Yonehiro Kanemura, Yoshinori Kodama, Masayuki Mano, Shin Nakajima

Affiliations

  1. Department of Neurosurgery, Osaka National Hospital, National Hospital Organization, Osaka 540-0006, Japan.
  2. Department of Neurosurgery, Osaka National Hospital, National Hospital Organization, Osaka 540-0006, Japan ; Division of Regenerative Medicine, Institute for Clinical Research, Osaka National Hospital, National Hospital Organization, Osaka 540-0006, Japan.
  3. Department of Central Laboratory and Surgical Pathology, Osaka National Hospital, National Hospital Organization, Osaka 540-0006, Japan.

PMID: 25789061 PMCID: PMC4356381 DOI: 10.3892/ol.2015.2940

Abstract

The prognosis of leptomeningeal dissemination of recurrent glioblastoma is poor, and chemotherapy results in minimal palliative efficacy. Temozolomide (TMZ) is an established therapy for patients with malignant glioma and the standard of care in parenchymal gliomas; however, few reports have been published with regard to its use for the treatment of leptomeningeal dissemination. Only one report has indicated the radiographic response of leptomeningeal dissemination to a TMZ rechallenge, suggesting a potential causative effect. While bevacizumab is an effective therapy for recurrent glioblastoma, its effect on leptomeningeal dissemination of recurrent glioblastoma remains unclear. The present study reports a case of leptomeningeal dissemination of recurrent glioblastoma in which transient neurological and radiological improvement was observed following chemotherapy with TMZ and bevacizumab. However, five months after the diagnosis of leptomeningeal dissemination the patient succumbed to the disease.

Keywords: bevacizumab; leptomeningeal dissemination; recurrent glioblastoma

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