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Nagai K, Matsumaru K, Hirai I, et al. New therapy using omega-3-Acid ethyl esters for decubitus ulcers and stasis dermatitis: a case report. Iran Red Crescent Med J. 2014;16(12):e19500doi: 10.5812/ircmj.19500.
Nagai, K., Matsumaru, K., Hirai, I., Takae, Y., & Andoh, K. (2014). New therapy using omega-3-Acid ethyl esters for decubitus ulcers and stasis dermatitis: a case report. Iranian Red Crescent medical journal, 16(12), e19500. https://doi.org/10.5812/ircmj.19500
Nagai, Kazuki, et al. "New therapy using omega-3-Acid ethyl esters for decubitus ulcers and stasis dermatitis: a case report." Iranian Red Crescent medical journal vol. 16,12 (2014): e19500. doi: https://doi.org/10.5812/ircmj.19500
Nagai K, Matsumaru K, Hirai I, Takae Y, Andoh K. New therapy using omega-3-Acid ethyl esters for decubitus ulcers and stasis dermatitis: a case report. Iran Red Crescent Med J. 2014 Dec 15;16(12):e19500. doi: 10.5812/ircmj.19500. eCollection 2014 Dec. PMID: 25763242; PMCID: PMC4341250.
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Iran Red Crescent Med J. 2014 Dec 15;16(12):e19500. doi: 10.5812/ircmj.19500. eCollection 2014 Dec.

New therapy using omega-3-Acid ethyl esters for decubitus ulcers and stasis dermatitis: a case report.

Iranian Red Crescent medical journal

Kazuki Nagai, Katsuhiko Matsumaru, Ikuko Hirai, Yujiro Takae, Kazuo Andoh

Affiliations

  1. Department of Internal Medicine, Nagai Clinic, Yokohama, Japan.
  2. Department of Dermatology, Saiseikai Yokohama-shi Nanbu Hospital, Yokohama, Japan.
  3. Department of Radiology, Saiseikai Yokohama-shi Nanbu Hospital, Yokohama, Japan.

PMID: 25763242 PMCID: PMC4341250 DOI: 10.5812/ircmj.19500

Abstract

INTRODUCTION: In daily practice, it is common to experience difficulty in treating decubitus ulcers (pressure ulcers, also known as decubitus ulcers) and stasis dermatitis of the lower limbs. We hereby report that omega-3-acid ethyl esters were remarkably effective when administered to cases of refractory pressure ulcers and stasis dermatitis for the purpose of improving the blood flow and promoting blood circulation.

CASE PRESENTATION: Case 1: A 21-year-old Japanese female with lower-body paralysis. Pressure ulcers appeared on the heel and first toe of her left lower extremity. Although the patient had been treated with various ointments such as dimethyl isopropylazulene and 0.9% iodine-containing ointment, the course showed no improvement, so omega-3-acid ethyl esters was administered orally, completely healing the ulcer of the first toe in 10 weeks. Case 2: A 76-year-old Japanese male. The patient had been treated on an outpatient basis for 15 years due to hypertension, heart failure, type 2 diabetes mellitus, and hyperlipidemia. Two years prior to this presentation, stasis dermatitis occurred in the lower limbs and at the end of last year, erosive ulcers appeared on the front part of the lower-right thigh and shin. Although treatment with various topical ointment and dressings was performed, the course showed no improvement. Oral administration of omega-3-acid ethyl esters was initiated. At 12 weeks, his condition entered the white phase and healed almost completely.

CONCLUSIONS: This report is the first to document other treatment possibilities for pressure ulcer and/or stasis dermatitis in cases where the use of topical applied ointments and medications is difficult. This new therapy may therefore help physicians to treat pressure ulcers and stasis dermatitis.

Keywords: Docosahexaenoic Acid Ethyl Ester; Ethyl-Eicosapentaenoic Acid; Omega-3 Fatty Acids; Pressure Ulcers

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